The Yale Journal of Biology and Medicine
June 1, 1957
D. X. Freedman
RAUWOLFIA. By R. E. Woodson, Jr., H. W. Youngken, E. Schlittler, and J. A. Schneider. Boston, Toronto, Little, Brown and Co., 1957. 137 pp. $5.50. For research workers who are interested in this important group of alkaloids, which includes the fascinating drug reserpine, this should prove to be a useful and compact reference volume because it is an attempt to collate all pertinent information...
Journal of Mental Science
April 1, 1957
R. A. Sandison, J. D. A. Whitelaw
80 citations
This paper follows a preliminary communication to this Journal two years ago (Sandison, Spencer and Whitelaw, 1954) and gives an account of the fuller experience gained up to the present time with lysergic acid diethylamide in the treatment of mental illness.
A M A Archives of Neurology & Psychiatry
April 1, 1957
Harris Isbell
50 citations
The effects of drugs on the abnormal mental state induced by the diethylamide of lysergic acid (LSD-25) are of interest from several points of view. Some means of mitigating too severe a reaction is needed in using LSD-25 experimentally or therapeutically. Since the LSD reaction is measurable and reproducible,1it might be possible to use the LSD psychosis as a screen for predicting the...
Annals of the New York Academy of Sciences
March 1, 1957
Julius Axelrod, Roscoe O. Brady, Bernhard Witkop et al.
154 citations
Late in the 1950s, Axelrod became interested in the distribution, excretion, metabolization and rate of "biotransformation" of lysergic acid diethylamide (LSD) by the body. In this first of several articles on the narcotic drug, he detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, determined that it...
Journal of Applied Physiology
March 1, 1957
Jack Arbit
9 citations
Four judges observed the effect of d-lysergic acid diethylamide (LSD-25) upon nine behavior indices in Siamese fighting fish, Betta splendens. The effect upon seven of the measures could be reliably categorized. B. splendens appear to be useful organisms in the bioassay of LSD-25. Submitted on August 31, 1956
Experimental Biology and Medicine
March 1, 1957
Parkhurst A. Shore, B.b. Brodie
60 citations
1. Administration of reserpine to rabbits pretreated with the monoamine oxidase inhibitor, iproniazid, causes excitation and sympathomimetic effects similar to those observed after administration of LSD or high doses of 5-hydroxytryptophan. These effects are associated with the presence of a high concentration of free serotonin in the brain. The observations are consistent with the concept that...
A M A Archives of Neurology & Psychiatry
February 1, 1957
Robert S. Liebert
23 citations
This study is concerned with the effect of change in organismic state, induced by a pharmacological agent, upon spatial localization. Aside from the current concern with the psychological effects induced by the drug, d -lysergic acid diethylamide (LSD-25)* the problem has its roots in two lines of investigation: 1. Studies of perception viewed in terms of an organismic theory of behavior, viz.,...
A M A Archives of Neurology & Psychiatry
November 1, 1956
Harris Isbell
112 citations
The striking mental changes induced by the diethylamide of lysergic acid (hereafter referred to as LSD) have been studied extensively in Europe,* Great Britain,† and the United States.‡ In minute doses (20γ to 120γ) LSD induces a peculiar mental state characterized by anxiety, signs of autonomic dysfunction, perceptual distortion (chiefly visual), alterations in mood and affect, synesthesias,...
Science
July 20, 1956
E Shaw, D. W. Woolley
88 citations
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Archives of Neurology And Psychiatry
July 1, 1956
Santo Salvatore
29 citations
Introduction Since the Swiss chemist Hoffman, on April 16, 1943, accidentally discovered the mental effects of lysergic acid diethylamide (LSD-25), a great many experiments with the drug have been reported in various journals. Observations show most agreement in the area of physical subjective symptoms and unreality and least agreement in changes of mood and behavior. Tremor, nausea, dilation...