Journal of Mental Science
1962
G Anastasopoulos, Harry Photiades
41 citations
Schizophrenic patients given LSD-25 show an increase of psychopathological phenomena and a regression to the prime stage of their psychosis, the manifestations of which seem to be more directly related to the life history of the patients. ∗ It has also been observed that some “normal” experimental subjects show various paranoid symptoms with the same drug, but whether these are in any way...
Journal of Mental Science
April 1, 1960
John Smythies, Carmit Levy
23 citations
There are, in the main, two principal methods of biological research into the problem of causation of schizophrenia. In the first, or direct method, studies are made of the body fluids and of the metabolism of schizophrenics in the hope of turning up some toxic factor or error of metabolism. Such studies are currently under way in a number of centres and, although many claims as to positive...
Journal of Mental Science
April 1, 1960
W. W. Roberts
This paper is offered as a contribution to the better understanding of depersonalization. It is divided into two sections. In the first section an account is given of the occurrence of brief episodes of depersonalization in young normal adults. In the second section a consistent interpretation of the symptoms of the syndrome itself is attempted. The two sections are loosely connected; the...
Journal of Mental Science
October 1, 1958
Frances R. Ames
184 citations
This paper describes an inquiry into the effects of giving oral doses of the narcotic drug variously known as hashish, marihuana and, in South Africa, dagga. The drug is a preparation from the plant Cannabis sativa whose narcotic effect has been known for centuries. The writer's interest in it was inspired by the work in recent years on the mental disturbances produced by the active principles...
Journal of Mental Science
October 1, 1958
J. C. Brengelmann, C. M. B. Pare, M. Sandler
31 citations
In the investigation described, the hypothesis was tested that 5-hydroxytryptamine (5HT) acts to reduce the psychological effects of lysergic acid diethylamide (LSD). The method was to inject 5-hydroxytryptophan (5HTP) prior to LSD and to compare the results of psychological tests performed after these injections. Placebo controls were used.
Journal of Mental Science
October 1, 1958
J. C. Brengelmann
10 citations
The present analysis pertains to the experiment reported by Brengelmann, Pare and Sandler (15) to assess the effect of 5-hydroxytryptophan (5-HTP) on lysergic acid diethylamide (LSD) by means of psychological tests. In the following, problems of measurement and validity of the LSD- “psychosis” are discussed.
Journal of Mental Science
April 1, 1958
Z. Böszörményi, St. Szára
38 citations
The so-called experimental psychoses have been in the focus of increased interest recently, as a result of the discovery of new hallucinogenic or psychotic agents and of the fact that the problems can be approached more closely even in the borderline fields of pathopsychological research (biochemistry, electrophysiology, etc.) owing to advance in technique. Thus, it appears that Kraepelin's...
Journal of Mental Science
April 1, 1958
D. J. Salfield
Depersonalization, derealization, unreality feelings, metamorphopsia and similar symptoms are not unusual in neuro-psychiatric patients. They are said to be extremely rare in children, Tramer (22) does not mention them, and Kanner (9) remarks only that “feelings of unreality are exceedingly rare in children. Things seem unreal to the patient, different from what he knows them to be. He is fully...
Journal of Mental Science
April 1, 1957
R. A. Sandison, J. D. A. Whitelaw
80 citations
This paper follows a preliminary communication to this Journal two years ago (Sandison, Spencer and Whitelaw, 1954) and gives an account of the fuller experience gained up to the present time with lysergic acid diethylamide in the treatment of mental illness.
Journal of Mental Science
1956
J. Amor Ardis, Peter Mckellar
17 citations
Similarity between certain of the visual effects of mescaline and hypnagogic imagery has been independently noted by several investigators, one of the earliest of these being Weir Mitchell (1896). Our own research group first became interested in hypnagogic experiences when one of the writers, as subject, in seeking to communicate the character of his mescaline visions, likened them to images...
Journal of Mental Science
July 1, 1955
Humphry Osmond
35 citations
This is an account of a model psychosis (6) produced by eating the seed of a tropical American plant which is known in Mexico as ololiuqui. It is only quite recently that Schultes (16) has made order from chaos in the matter of the identity of a climbing vine calledRivea corymbosa.I was introduced to ololiuqui by Mr. Leslie LeCron during a visit to Los Angeles in which he showed me Taylor's...
Journal of Mental Science
April 1, 1955
Dwight I. Peretz, John Smythies, William C. Gibson
55 citations
3,4,5-Trimethoxyphenyl-β-aminopropane (TMA) is structurally related to both amphetamine and mescaline, as is shown in Figure 1. Because of this structural relationship of TMA and amphetamine, methedrine, and mescaline, one could anticipate a clinical response to the compound which would represent certain phenomena characteristic of each of these drugs. This presented an intriguing problem as to...
Journal of Mental Science
1955
N. Agnew, A. Hoffer
26 citations
Theoretical models ranging from neurological to analytical have been introduced in the hope of providing new insights into psychopathology. The flesh and blood model is of more recent origin in this field. The experimental or model psychosis results from giving “normals” drugs which bring about a psychotic-like experience for a few hours. As is the case with theoretical models, the flesh and...
Journal of Mental Science
April 1, 1954
R. A. Sandison, A. M. Spencer, J. D. A. Whitelaw
191 citations
D-lysergic acid diethylamide (LSD 25) was first prepared in 1938 by Stoll and Hofmann. It is the synthetic amide of d-lysergic acid with a secondary amine, diethylamine and belongs to the ergonovine group of ergot alkaloids all of which have lysergic acid as a base. After its ingestion in minute doses, it induces psychic states in which the subject becomes aware of repressed memories and other...
Journal of Mental Science
April 1, 1954
R. A. Sandison
90 citations
Recent work by the author and his colleagues (Sandison, Spencer and Whitelaw, 1954) has established that lysergic acid diethylamide is of great value in the psychotherapy of the neuroses. This paper attempts to examine in rather more detail the possible mechanism of action of the drug in terms of dynamic psychology. It is now generally accepted that the psychoneuroses are the result of a faulty...
Journal of Mental Science
1954
A. Hoffer, H Osmond, John Smythies
300 citations
About one year ago, with the encouragement of the Editor-in-Chief, a short paper appeared in this Journal entitled “Schizophrenia; A New Approach” (18). In this paper it was noted that mescaline and adrenaline have a similar biochemical structure. It was suggested that one of the aetiological agents in schizophrenia might be a substance or substances lying between these two; with the...
Journal of Mental Science
July 1, 1952
Ashley A. Robin, E. J. Harrison
A search of the literature has not revealed a report of the depersonalization syndrome occurring in identical twins, although Palmer (1946) published a report of twins in which one patient was described as suffering from “all round loss of interest with some depression…. His thoughts … milled round in a ceaseless turmoil concerning his loss of contact with people and things. There was some...
Journal of Mental Science
October 1, 1949
Sidney Bockner
This paper presents an example of the depersonalization syndrome as experienced and described by an intelligent patient. Considering the frequency of its occurrence, this syndrome has not been as often recognized nor as adequately described as would be expected. The syndrome was first described by Mayer-Gross (1935), later by Gordon (1936), Shorvon (1946, 1947) and Tayleur Stockings (1947). The...
Journal of Mental Science
1947
G. Tayleur Stockings
Depersonalization, or feeling of unreality, is a symptom which may occur as part of several psychiatric conditions, such as hysteria, anxiety and obsessional states, and some forms of schizophrenia and endogenous depression. The true derealization-depersonalization syndrome, however, in which the unreality symptom is the primary disturbance, is a quite peculiar and distinctive condition, which...
Journal of Mental Science
1940
G. Tayleur Stockings
64 citations
The experimental reproduction of psychotic phenomena in the normal person is a subject which has attracted much attention in recent years from psychiatrists, and which has added remarkable and interesting facts to our clinical knowledge.
Journal of Mental Science
May 1, 1936
E. Guttmann
67 citations
Progress in general medicine is brought about by clinical observation or carefully controlled experimental research. In psychiatry there is little opportunity for the latter approach. One of the few methods available at the present time is the use of intoxicating drugs. It was Kraepelin who first emphasized the importance of studying psychological changes produced by drugs. Following his lead...