Studies in the Effects of Lysergic Acid Diethylamide (LSD-25)
A M A Archives of Neurology & Psychiatry February 1, 1957 DOI: 10.1001/archneurpsyc.1957.02330320091012 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Intervention | d-lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Keywords | Pharmacology |
| Citations | 23 |
| Key findings | LSD-25 affects spatial localization by altering the organismic state, consistent with sensory-tonic theory of perception. |
Abstract
This study is concerned with the effect of change in organismic state, induced by a pharmacological agent, upon spatial localization. Aside from the current concern with the psychological effects induced by the drug, d -lysergic acid diethylamide (LSD-25)* the problem has its roots in two lines of investigation: 1. Studies of perception viewed in terms of an organismic theory of behavior, viz., sensory-tonic field theory of perception. 2. Studies of perception from the comparative and developmental point of view; here, the effect of this drug is significant because previous investigations have found that it produces primitive behavior in normal adults. 1,4,6,8 Sensory-tonic theory of perception, within which the present study was conceived, stands in contrast to traditional theories, which treat perception as a relatively isolated event. According to sensory-tonic theory, perception is held to be not simply a function of stimulus conditions but, rather, a function of the relations obtaining
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 4
- Studies in the Effect of Lysergic Acid Diethylamide (LSD-25) A M A Archives of Neurology & Psychiatry May 1, 1958
- LSD and JB318: A Comparison of Two Hallucinogens A M A Archives of General Psychiatry April 1, 1960
- Effects of LSD, DMT and psilocybin on cognitive and psychological functions: A systematic review of the literature Journal of Psychopharmacology February 16, 2026
- Psychedelic drugs and perception: a narrative review of the first era of research Reviews in the Neurosciences February 5, 2021