LSD-Like Effects Elicited by Reserpine in Rabbits Pretreated With Iproniazid.
Parkhurst A. Shore, B.b. Brodie
Experimental Biology and Medicine March 1, 1957 DOI: 10.3181/00379727-94-22968 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbits |
| Interventions | Reserpine Iproniazid Chlorpromazine |
| Topics | Serotonin LSD |
| Keywords | Iproniazid Reserpine Chlorpromazine Monoamine oxidase inhibitor Pharmacology 5-hydroxytryptophan Nialamide Endocrinology |
| Citations | 60 |
| Key findings | Reserpine administration after iproniazid pretreatment causes excitation linked to high free serotonin in the brain, and chlorpromazine but not reserpine blocks the effects of free serotonin. |
Abstract
1. Administration of reserpine to rabbits pretreated with the monoamine oxidase inhibitor, iproniazid, causes excitation and sympathomimetic effects similar to those observed after administration of LSD or high doses of 5-hydroxytryptophan. These effects are associated with the presence of a high concentration of free serotonin in the brain. The observations are consistent with the concept that serotonin is normally bound in an inactive form which serves as the precursor form of a neurohumoral agent. 2. Although both chlorpromazine and reserpine reverse the effects of LSD, only chlorpromazine blocks the effects of free serotonin which result from administration of 5-hydroxytryptophan or the combination of iproniazid and reserpine. This suggests that the two tran-quilizing drugs act by different mechanisms.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |