Studies on the Diethylamide of Lysergic Acid (LSD-25)
A M A Archives of Neurology & Psychiatry April 1, 1957 DOI: 10.1001/archneurpsyc.1957.02330340026002 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Adult male drug addicts serving sentences for violation of the Harrison Act |
| Interventions | Chlorpromazine Azacyclonol (Frenquel) Reserpine |
| Topics | LSD |
| Citations | 50 |
| Key findings | Chlorpromazine blocks and reverses the LSD-25 reaction, whereas azacyclonol and reserpine do not. |
Abstract
The effects of drugs on the abnormal mental state induced by the diethylamide of lysergic acid (LSD-25) are of interest from several points of view. Some means of mitigating too severe a reaction is needed in using LSD-25 experimentally or therapeutically. Since the LSD reaction is measurable and reproducible,1it might be possible to use the LSD psychosis as a screen for predicting the potential clinical value of new tranquilizing drugs. In addition, such studies might be useful in elucidating the mechanisms of action of both the tranquilizers and the psychotogenic drugs. The purpose of the present paper is to present the results of experiments in which attempts were made to block (prevent) or reverse (treat) the LSD reaction with chlorpromazine, azacyclonol (Frenquel), and reserpine. Methods Subjects.— The subjects used in these experiments were all adult male drug addicts who were serving sentences for violation of the Harrison
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 19
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Dose-Response Study of N,N-Dimethyltryptamine in Humans Archives of General Psychiatry February 1, 1994
- The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act Neuropharmacology June 5, 2018
- Dreams, Hallucinogenic Drug States, and Schizophrenia: A Psychological and Biological Comparison Schizophrenia Bulletin 1983
- The relationships of classic psychedelic use with criminal behavior in the United States adult population Journal of Psychopharmacology October 17, 2017
and 14 more in the library