Pharmacologic and toxic effects of xenobiotics, such as drugs of abuse, depend on the genotype and phenotype of an individual, and conversely on the isoenzymes involved in their metabolism and transport. The current knowledge of such isoenzymes of frequently abused therapeutics such as opioids (oxycodone, hydrocodone, methadone, fentanyl, buprenorphine, tramadol, heroin, morphine and codeine),...
ANMELDELSERLSDs basale farmakologi.Her har den i seg stoff til å være et referanseverk for farmakologer og toksikologer.Dette er sentralt fagstoff om kjemisk struktur, metabolitter, reseptorvirkning, interaksjoner og dyreforsøk på toksisitet.Her er boken omfattende nok og relativt nyansert, selv om den refererende stilen, uten synteser, gjør teksten tung å lese noen ganger.Dette utgjør nesten...
The prevalent view today is that schizophrenia is a syndrome rather than a specific disease. Liability to schizophrenia is highly heritable. It appears that multiple genetic and environmental factors operate together to push individuals over a threshold into expressing the characteristic clinical picture. One environmental factor which has been curiously neglected is the evidence that certain...
A quantitative meta-analysis was carried out on the chronic effects of ecstasy use on working memory (WM), assumed to consist of a central executive (CE) and four executive subcomponents: Updating, Attention shifting, Inhibition and Access to long term memory. Publications dating from January 1998 to January 2008 were only included when they fulfilled the criteria for a meta-analysis (number of...
After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent advances in our understanding of the neurobiology of psychedelics, such as lysergic acid diethylamide (LSD), psilocybin and ketamine have led to renewed interest in the clinical potential of psychedelics in the treatment of various psychiatric disorders. Recent behavioural and neuroimaging data show that...
On 30 October 2009, the home secretary in the UK asked David Nutt to resign from his post as chairman of the government's advisory council on the misuse of drugs. The previous day, the Centre for Crime and Justice Studies at King's College London had published Nutt's paper, ‘Estimating drug harms: a risky business?’. This is an edited version of his Eve Saville memorial lecture, delivered at...
Trifluoromethylphenyl piperazine (TFMPP) is an active constituent of a relatively new group of recreational drugs known as 'party pills'. TFMPP has been anecdotally reported to induce mild psychedelic effects similar to lysergic acid diethylamide and psilocybin. There has been no research about the subjective effects of TFMPP in humans. This study aimed to investigate the subjective effects of...
Mark S. Morrisson : Modern Alchemy: Occultism and the Emergence of Atomic Theory . Oxford : Oxford University Press , 2007 ; pp. 262 . In this monograph Morrison traces the emergence of atomic science through the fascinating interrelationship between science and occultism. The text evidences an eye for detail and a comprehensive knowledge of both scientific and occult discourses. Specifically,...
This article offers a comparative analysis of aspects of the careers of two celebrated 1960s popular musicians, Brian Wilson of The Beach Boys and Syd Barrett of Pink Floyd. Through formal and contextual readings of selected songs, it argues that during 1967, in the hands of Barrett, Wilson and his lyricist Van Dyke Parks, the incongruous, semantically complex figure of the vegetable came to...