2 papers in the library · 337 citations · publishing 1957-1961
Science August 4, 1961 Julius Axelrod 183 citations
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine, mescaline, and dopamine.
Annals of the New York Academy of Sciences March 1, 1957 Julius Axelrod, Roscoe O. Brady, Bernhard Witkop et al. 154 citations
Late in the 1950s, Axelrod became interested in the distribution, excretion, metabolization and rate of "biotransformation" of lysergic acid diethylamide (LSD) by the body. In this first of several articles on the narcotic drug, he detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, determined that it...