A M A Archives of Neurology & Psychiatry
February 1, 1958
Theodore Greiner
47 citations
Despite 14 years of investigation, as intensive as accorded any biologically active chemical, a gap remains in the systematic description of human response to lysergic acid diethylamide (LSD-25). The dramatic schizophrenic-like symptoms after doses of 40μg to 100μg have drawn the main interest. The threshold for activity is placed at 20μg by general consensus, while perfunctory administration...
New England Journal of Medicine
January 2, 1958
George B. Koelle
18 citations
DURING the last few years a great revival of interest has occurred in the search for a biochemical basis for schizophrenia and the other types of psychosis. There are several reasons for this. Modern laboratory technics permit the detection and accurate quantitation of substances in the blood and tissues for which satisfactory procedures were not available formerly. The discovery of a partially...
The Japanese Journal of Pharmacology
1958
Hiroshi Takagi, Shigeru Yamamoto, Shuji Takaori et al.
11 citations
In 1943 in Switzerland, A. Hofmann (1) working on the synthesis of lysergic acid diethylamide (LSD-25), a common fragment of ergot alkaloids, noticed the peculiar sensation of vertigo and restlessness. Thenceforce it was reported by Stoll et al. (1, 2), Forrer et al. (3) and Rinkel et al. (4) that a small dose of LSD caused predominantly schizophrenic symptoms that were manifested in...
British Journal of Pharmacology and Chemotherapy
December 1, 1957
T. E. Mansour
51 citations
The rhythmical activity of the liver fluke, Fasciola hepatica, was stimulated by 5-hydroxytryptamine and by lysergic acid diethylamide at very low concentrations. The effect was peripheral and was not mediated through the central ganglion. Other amines also stimulated rhythmical activity, the most potent being the indolamines.Bromolysergic acid diethylamide, and other analogues such as...
A M A Archives of Neurology & Psychiatry
December 1, 1957
Lincoln D. Clark
19 citations
One consequence of the recent interest in psychotomimetic drugs has been a search for pharmacological agents that will "block" drug-induced psychological disturbances and hallucinations. Fabing1reported that azacyclonol (Frenquel) in small doses prevented the occurrence of lysergic acid diethylamide (LSD-25) "psychoses" in man, although one of us (L. D. C.) was unable to verify this...
Journal of Pharmacy and Pharmacology
September 1, 1957
E Rothlin
64 citations
Journal Article Pharmacology of Lysergic Acid Diethylamide and Some of Its Related CompoundS Get access E Rothlin E Rothlin Professor of the University of Basle, Sonnenweg 6, Basle Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 9, Issue 1, September 1957, Pages 569–587, https://doi.org/10.1111/j.2042-7158.1957.tb12312.x...
British Journal of Pharmacology and Chemotherapy
September 1, 1957
William A. Krivoy
23 citations
Lysergic acid diethylamide (LSD) potentiated the response of guinea‐pig ileum to substance P but not to histamine. It also inhibited the disappearance of substance P when incubated with guinea‐pig brain extract but not when incubated with chymotrypsin. Eserine, morphine, mescaline, chlorpromazine, ergometrine, strychnine and 2 bromo‐LSD did not have this effect. Oxytocin was not destroyed by...
A M A Archives of Neurology & Psychiatry
September 1, 1957
William K. Boardman
21 citations
Introduction Much of the interest in lysergic acid diethylamide (LSD) is due to its capacity to produce schizophrenic-like behavior when administered in extremely small quantities. 4,6 Among the reported changes resulting from LSD have been alterations in time perception. DeShon, Rinkel, and Solomon, 1 found changes in the form of experiences of acceleration, retardation, or nonexistence of...
The Journal of Nervous and Mental Disease
July 1, 1957
Juliana Day
2 citations
PUBLIC HEALTH SERVICE NATIONAL INSTITUTE OF MENTAL HEALTH NATIONAL INSTITUTES OF HEALTH BETHESDA, MARYLAND
The Journal of Nervous and Mental Disease
July 1, 1957
Herman C. B. Denber, Herman C. B. Denber, Max Rinkel
8 citations
DENBER, HERMAN C. B. M.D.; DENBER, HERMAN C. B. M.D.; RINKEL, MAX M.D., F.A.P.A. Author Information