Journal of Pioneering Medical Sciences
December 5, 2026
C Cecyli., Nidhi Sharma, P. Thenmozhi
Individuals receiving maintenance hemodialysis for Chronic Kidney Disease (CKD) frequently encounter complex physical, emotional and social challenges that substantially diminish their Quality of Life (QoL). Mindfulness-Based Stress Reduction (MBSR) has increasingly been recognized as a supportive, non-pharmacological strategy for enhancing well-being in populations with chronic illness. This...
European Journal of Psychotraumatology
December 1, 2026
Maud Rothärmel, Lila Mekaoui, François Kazour et al.
1 citation
Background: Posttraumatic stress disorder (PTSD) is a severe and frequent affection that is highly comorbid to major depressive disorder. Comorbid PTSD and depression increase the risk of treatment-resistant depression (TRD), with a high risk of functional impairment and suicide. Esketamine nasal spray is a recent validated treatment for TRD, but its efficacy on comorbid TRD-PTSD remains...
European Journal of Psychotraumatology
December 1, 2026
Chulei Tang, Ting Zhao, Simin Yu et al.
Background: Posttraumatic stress disorder (PTSD) is highly prevalent among people with HIV (PWH) and is associated with poor psychological functioning and reduced adherence to antiretroviral therapy (ART), threatening treatment outcomes. Although the Community Resiliency Model (CRM) and mindfulness-based stress reduction (MBSR) have separately demonstrated efficacy for PTSD, no intervention...
European Journal of Psychotraumatology
December 1, 2026
Philip Gerrans, Hugh McGovern, Jakob Hohwy et al.
Background: Complex post-traumatic stress disorder (C-PTSD) is a trauma-related condition characterized by pervasive disturbances in affect regulation, self-concept, and interpersonal functioning that extend beyond the symptom profile of post-traumatic stress disorder (PTSD). While neurobiological studies have implicated limbic, salience, and prefrontal systems in C-PTSD, mechanistic accounts...
European Journal of Psychotraumatology
December 1, 2026
V Ursule Taujanskaite, Sunjeev K. Kamboj
Background: State dissociation is commonly assessed using the Clinician Administered Dissociative States Scale (CADSS; 19-items). A briefer CADSS would have many advantages, enabling assessment of transient dissociative states and allowing repeated assessment within short intervals while minimizing participant burden. This is especially relevant in studies of dissociative drugs which cause...
Annals of medicine
December 1, 2026
Zheping Chen, Yaozhu Wang, Peilin Cong et al.
Patients undergoing acoustic neuroma (AN) surgery often experience postoperative negative emotions, including anxiety, depression, and immune function suppression. This trial evaluated whether perioperative sub-anesthetic esketamine improves early postoperative negative emotions and immune function. In this single-center, double-blind, randomized trial, 84 patients scheduled for AN surgery were...
Neuropharmacology
November 1, 2026
Vincenzo Crunelli, Tatiana P Morais, William M Connelly et al.
Renewed interest in psychedelic therapeutics has brought serotonin 5-HT2A receptors (5-HT2ARs) back into focus. Given the role of the thalamus in sensory integration and network synchronization, we examined the expression, developmental regulation, and functional impact of thalamic 5-HT2ARs, with particular emphasis on their interaction with extrasynaptic GABAA receptors and the generation of...
Journal of Affective Disorders
November 1, 2026
Dian‐jeng Li, Tien-Wei Hsu, Te-Chang Changchien et al.
Little is known about esketamine's effectiveness for patients with major depressive disorder (MDD) comorbid substance use disorders (SUD). We conducted a retrospective cohort study using the TriNetX US Collaborative Network, including adults aged ≥18 years with MDD. Three propensity-score-matched (1:1) cohorts were defined based on treatment: esketamine, antidepressant-only, and repetitive...
Journal of Affective Disorders
November 1, 2026
Veronica L O'Brien, Nicolette P. Rickert
Research has established that higher trait mindfulness is inversely associated with psychopathology in cross-sectional and longitudinal studies, and research has also demonstrated that mindfulness-based interventions increase trait mindfulness over time. The present study sought to investigate the trajectory of mindfulness development by examining whether repeated practice of state mindfulness...
Journal of Affective Disorders
November 1, 2026
Cengiz Taşkaya, Leyla Sezgin, Necmettin Çiftci
Mothers of children with physical disabilities often experience caregiving-related stress that may negatively affect their psychological well-being and quality of life. Mindfulness-based interventions may help reduce stress by improving awareness and emotional regulation. This study aimed to examine the effect of a mindfulness-based stress reduction (MBSR) program on parental stress,...
Journal of Affective Disorders
November 1, 2026
Lindsay L Benster, Jordan N Kohn, Benjamin Wade et al.
Repetitive transcranial magnetic stimulation (rTMS) and intranasal esketamine are FDA-approved for treatment-resistant depression (TRD), yet comparative real-world data on response trajectories and predictors of outcomes remain limited. A retrospective analysis was performed using electronic medical records from UC San Diego Health. Adults with TRD treated with rTMS (n = 279) or intranasal...
Journal of Affective Disorders
November 1, 2026
Tse-Hwei Choo, Hanga C Galfalvy, John G Keilp et al.
Depression and its severe outcomes, suicidal ideation and behavior, are exacerbated by stress. A broad literature links dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) stress response system to depression, suicidal ideation and behavior. Our midazolam-controlled clinical trial of subanesthetic, intravenous ketamine infusion for suicidal depressed patients found rapid reduction...
Journal of Affective Disorders
November 1, 2026
Carlton M Kelly, Mathieu Fradet, Catherine Bostian et al.
Psilocybin has demonstrated promise for improving depressive symptoms in treatment-resistant depression, but its effects on anxiety, quality of life, functioning, and posttraumatic stress symptoms are less well studied. This study reports exploratory findings from an open-label trial in Veterans with TRD. Participants received a single 25-mg dose of psilocybin administered with psychological...
Sleep Medicine
October 1, 2026
Emilie Gagneron, Katayoun Rezaei, Romain Perot et al.
Suicide is a major public health concern, and identifying early indicators of suicidal crisis remains a key clinical challenge. Nightmares have been suggested as potential early markers of suicide risk. This study aimed to investigate dream alterations preceding a suicidal crisis in patients presenting to a psychiatric emergency department. This prospective study was conducted in a psychiatric...
Epilepsy & behavior : E&B
October 1, 2026
Saranya B Gomathy, Sandhya Sharma, Gautam Sharma et al.
Functional dissociative seizures (FDS) are paroxysmal seizure-like events with no electrographic abnormalities. Structured psychoeducation is considered a standard component of FDS management. Yoga Nidra (YN) is a guided meditative relaxation technique that has shown benefit in other neuropsychiatric conditions, but its adjunctive role in FDS has not been studied. To evaluate whether adjunctive...
Neuropharmacology
September 15, 2026
Taisiia Prosvirova, Wiktoria Podolecka, Jacek Wróbel et al.
Ketamine produces rapid antidepressant effects accompanied by marked changes in fast brain rhythms. High-frequency oscillations (HFO; 130-180 Hz) are an increasingly recognized signature of ketamine across species. However, their relationship to classical gamma activity and their circuit-level organization remain unclear. Using simultaneous multiregion recordings in freely moving male Wistar...
Journal of Affective Disorders
September 15, 2026
Rutger Boesjes, Claudia Oosterveld, Jeanine Kamphuis et al.
1 citation
Ketamine, including its enantiomers (S)-ketamine (esketamine) and (R)-ketamine (arketamine), has demonstrated rapid antidepressant effects in major depressive disorder (MDD) and bipolar disorder (BD), yet clinical responses vary widely, highlighting the need to identify mechanisms underlying treatment efficacy and related potential predictors. Growing evidence suggests that alterations in sleep...
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
September 1, 2026
Denis O'Dwyer, Ashwin Subramaniam, Dean McKenzie et al.
Acute stress impairs attention and procedural performance in high-acuity environments. Whether brief mindfulness-based interventions are feasible and affect performance in intensive care unit (ICU) simulation training is unknown. To evaluate the feasibility of a brief mindfulness-based intervention before simulated ultrasound-guided central venous access device (CVAD) insertion. Single-centre...
Neuropsychopharmacol Rep
September 1, 2026
Daisuke Ibi, Rika Takaba, Keisuke Yoshida et al.
Contribution of the Serotonin 5-HT2A Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat Stress.
Neuroscience and Biobehavioral Reviews
September 1, 2026
Jeremy I Skipper, Daniel R Lametti, David W Green
Aberrations of inner speech have been linked to psychotic symptoms such as thought insertion and auditory verbal hallucinations. These symptoms may reflect failures of prediction and source monitoring. Normally, efference copies of speech motor commands are sent to auditory cortices and suppressed, helping distinguish self-generated from external input. If suppression malfunctions, predicted...
Neuroscience and Biobehavioral Reviews
September 1, 2026
Isabella Goodwin, Dominic Oliver, Edward Chesney et al.
Global shifts towards the liberalisation of cannabis policies have increased the potency of cannabis products, alongside their accessibility, diversity, and the number of inexperienced cannabis consumers. There is a lack of systematic evidence on the subjective effects of cannabis' main psychoactive compound, Δ9-tetrahydrocannabinol (THC). We systematically reviewed and meta-analysed data from...
Journal of Psychosomatic Research
September 1, 2026
Keyuan Liu, Geoffroy Solelhac, Nicola Andrea Marchi et al.
Nightmares can trigger stress responses and lead to insufficient or poor-quality sleep, which are associated with cardiometabolic diseases (CMD) and their risk factors. However, research on the association and underlying mechanisms between nightmares and CMD in the general population remains limited. Data from three follow-ups of the CoLaus|PsyCoLaus study (Lausanne, Switzerland). Frequent...
Brain Research Bulletin
September 1, 2026
Qiang Chen, Yating Zhang, Chenrui Liu et al.
This scoping review systematically compares the neural mechanisms underlying trait mindfulness and hypnosis susceptibility, focusing on three key dimensions: brain region activation, electroencephalographic (EEG) signals, and core brain networks. The aim is to elucidate potential shared mechanisms involved in conscious state modulation. Through a comprehensive review of existing brain imaging...
Forensic Science International
September 1, 2026
Byungsuk Cho, Seonghoon Yeon, Sanghee Woo et al.
In early 2025, an unidentified white powder suspected illicit drug was submitted to National Forensic Service (NFS) for analysis and was subsequently identified as 2F-2-oxo-PCPr. 2F-2-oxo-PCPr is a structurally modified ketamine analogue characterized by the replacement of the aromatic chlorine substituent with fluorine and the substitution of the amine methyl group with a propyl group....