Frontiers in Public Health
September 15, 2026
Pedram Dara
As psychedelic interventions move from controlled clinical trials into broader implementation, critical dimensions of lived experience among patients, trial participants, families, and caregivers remain systematically undermeasured in research, service design, and oversight. The resulting gap between protocol-defined outcomes and real-world experiences over time creates blind spots in current...
Chinese medical journal
September 15, 2026
Yingjie Du, Xiangting Zhao, Quan Chen et al.
Psilocybin facilitates fear extinction in rodents, but its clinical utility is hampered by 5-hydroxytryptamine (5-HT) 2A-receptor-mediated hallucinogenic effects. This study aimed to explore whether 5-HT2A receptor is obligatory for psilocybin's fear extinction and neuroplasticity effect. Male C57BL/6J mice underwent auditory-cue fear conditioning. Ketanserin (5-HT2A/2C antagonist) or MDL100907...
Actas Españolas de Psiquiatría
September 15, 2026
Xiaodan Zhang, Miao Wang, Qin Fu
Background: To examine the association between a mindfulness-based stress reduction (MBSR) nursing model and changes in quality of life in patients with chronic tonsillitis complicated by anxiety disorder. Methods: This retrospective study analyzed propensity score-matched data from 110 patients (55 per group) with chronic tonsillitis and comorbid anxiety disorder treated at Yingshang County...
Journal of Cognitive Enhancement
September 14, 2026
Katherine Harrison, Jessica Halverson, Tina Ozbeki et al.
Abstract Despite substantial efforts to understand the impact of cannabis use on cognition, the potential effects remain debated. More research focusing on how cannabis is used, specifically around the quantity used and cannabis co-use with other substances, is needed to better understand the outcomes of cannabis use. Current cannabis users were asked to report all substance use history and...
Zenodo (CERN European Organization for Nuclear Research)
September 14, 2026
Shaun Robinson
Psilocybin and related psychedelics can induce transient states of increased neural variability, context sensitivity, and plasticity-associated signaling. We hypothesize that selected companion botanicals can be composed with psilocybin to create a reproducible physiological and experiential lens, a botanical context, that biases the qualitative trajectory of the psychedelic state without...
Frontiers in Neuroscience
September 14, 2026
Daria Malich, Andrii Vasylyshyn
Testosterone exerts widespread effects on brain structure and function, yet its influence on large-scale neural networks, particularly the default mode network (DMN), remains poorly understood. The role of the DMN in self-referential processing, social cognition, and mood regulation has been demonstrated over the last decade. Neuroimaging studies suggest a link between testosterone and...
Zenodo (CERN European Organization for Nuclear Research)
September 14, 2026
Prafful Singi, Mukul Pal Chowdhury, Rajesh Arora
While modern contemplative science has extensively investigated mindfulness and meditation techniques, the critical chronobiological variable of timing remains largely unexplored. Ancient Eastern traditions universally emphasize the pre-dawn window—traditionally termed Brahma Muhurta or Amritvela (3:00 AM – 6:00 AM)—as the optimal time for spiritual practice. This paper establishes an...
Zenodo (CERN European Organization for Nuclear Research)
September 14, 2026
Daryl Jacobs
A write up for discussion. Consciousness as a process
Psychedelic Medicine
September 14, 2026
Vasileios Chytas, Georgios Tsimploulis, Dimitrios Chytas
Purpose: Ketamine and classic psychedelics have recently gained increased scientific interest regarding their role in pain management, while there is evidence that pain induces neural connectivity changes. We performed a scoping review to investigate the correlation of ketamine and classic psychedelics with pain-related neural connectivity, aiming to find potential therapeutic targets for these...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
The phenomenon of “REM (Rapid Eye Movement) sleep,” in which the eyeballs move vigorously despite skeletal muscle relaxation induced by the sleep center, has traditionally been interpreted in conventional neuroscience as a “leakage of random brain activity associated with memory consolidation.” However, from the perspective of the biological Quantum Processing Unit (Bio QPU) theory, this...
Religions
September 13, 2026
Heather Kempton
This article introduces the concept of the digital kōan, an AI-mediated contemplative prompt that functions as a catalyst for self-inquiry rather than a source of spiritual knowledge. Drawing on Buddhist psychology, cognitive science, and contemplative phenomenology, it examines how dialogue with conversational artificial intelligence can reveal the constructed nature of identity and illuminate...
Anesthesia Research
September 13, 2026
Camilla Teixeira Pinheiro Gusmão, Batuhan Özen, Marina Seixas Studart E Neves et al.
Background/Objectives: Fibromyalgia (FM) is a nociplastic pain syndrome characterized by chronic widespread pain, fatigue, sleep disturbance, cognitive dysfunction, and heightened sensitivity to somatic and environmental stimuli. Depressive symptoms and major depressive disorder (MDD) frequently co-occur with FM and are associated with greater disability, pain catastrophizing, sleep disruption,...
Figshare
September 13, 2026
Purpose - The purpose of this study was to investigate the effects of the spatial openness of the natural environment on individuals’ environmental and mindfulness perception by using virtual reality tools, with an aim of guiding health-oriented community environmental design.Design/methodology/approach - We employed two within-subject crossover studies that included four sessions: one involved...
Figshare
September 13, 2026
Purpose - The purpose of this study was to investigate the effects of the spatial openness of the natural environment on individuals’ environmental and mindfulness perception by using virtual reality tools, with an aim of guiding health-oriented community environmental design.Design/methodology/approach - We employed two within-subject crossover studies that included four sessions: one involved...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
Nova Spivack
Paper 65 proved that known qualia are irreducible semantic content whose actuality is Alpha-grounded. That result establishes grounding but does not yet establish manifestation: the thesis that qualia are the phenomenal manifestation of Alpha-grounded actuality. The present paper closes that gap. We define phenomenal presence independently of ground-mode, prove that known qualia have phenomenal...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
Nova Spivack
This paper develops the formal phenomenology layer that extends the operational boundary theory of unified agency established in Paper 73 . Paper 73 characterized the structural conditions under which a system forms a unified self-indexing adjudicative regime (O-SIAM). The present paper asks what additional formal structure is required for manifestation, qualia, subjectivity, and self-presence...
PARADIGM OF KNOWLEDGE
September 13, 2026
Elena Andriyenko
The relationship between analytical psychology and the symbolic system of the Tarot has attracted considerable interest among psychologists, historians of religion, cultural theorists, and practitioners of depth psychology. Although Carl Gustav Jung did not develop a systematic psychological theory of Tarot and did not establish a canonical correspondence between the Major Arcana and his...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
George Wanjau
This thesis proposes a unified framework integrating five levels of human cognition and perception into a single coherent architecture. It begins where the reader already lives, with the fast and slow processing systems familiar from Kahneman’s dual-process account, and shows that the ego is not a further component of that architecture but the experiential view generated by the sustained...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
Jiaping Wang
Mainstream theories of consciousness largely address what Chalmers calls the easy problems and do not explain, from first principles, why a complete third-person description cannot recover first-person experience. Starting from three axioms (finite resources, non-equilibrium persistence, and discrete input) and arguing by eliminative convergence, this paper forms an Information Capacity Frame...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
Akash Pawar
The Empirical-Axiomatic Framework (EAF) is a broader foundational framework concerned with existence, ontological structure, consistency, logic, information, representation, knowledge, scientific modelling, consciousness, and related philosophical questions. This paper develops the epistemological part of EAF by establishing a conceptual relation between underlying structures, representations,...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
Prasanth Retnakaran-Saraswathy
Consciousness remains one of the most difficult problems in science because subjectiveexperience is accessible directly only from the first-person perspective, whereas scientificmeasurement is primarily third-person and physical. This article proposes a hypotheticalinterpretation within the Wavy Universe Consciousness Cycle (WUCC) and Binary VacuumParadox (BVP) frameworks: consciousness should...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
Amit Chai
AbstractThis treatise, "The Grand Synthesis," presents a rigorous philosophical and hermeneutic framework that explores structural analogies between modern theoretical physics (quantum information theory, cosmology, and the Standard Model) and the ancient cosmogony of Sefer Yetzirah and Kabbalah. Rather than attempting to "prove" ancient texts through modern science or vice versa, this work...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
Alexander Ohnemus
This essay proposes a speculative research program for investigating the Gateway Process using advanced artificial intelligence and a hypothetical large-scale “artificial brain.” It explores whether Gateway-inspired altered states of consciousness could potentially be modeled, experimentally tested, and used to investigate two extraordinary hypotheses: whether consciousness can obtain...
Zenodo (CERN European Organization for Nuclear Research)
September 13, 2026
John Giles
The Unified Quantum Consciousness Postulation (UQCP) proposes that consciousness is not generated locally by biological tissue but is accessed through a physical interface. The framework distinguishes a proposed quantum tether, which would make field access possible, from a coupling state that would modulate the depth, stability, mode, or fidelity of that access. Neuronal microtubules are...