The effects of drugs on the abnormal mental state induced by the diethylamide of lysergic acid (LSD-25) are of interest from several points of view. Some means of mitigating too severe a reaction is needed in using LSD-25 experimentally or therapeutically. Since the LSD reaction is measurable and reproducible,1it might be possible to use the LSD psychosis as a screen for predicting the...
The striking mental changes induced by the diethylamide of lysergic acid (hereafter referred to as LSD) have been studied extensively in Europe,* Great Britain,† and the United States.‡ In minute doses (20γ to 120γ) LSD induces a peculiar mental state characterized by anxiety, signs of autonomic dysfunction, perceptual distortion (chiefly visual), alterations in mood and affect, synesthesias,...