Archives of Neurology And Psychiatry
May 1, 1959
Sidney Cohen
49 citations
In experimental psychiatry the hallucinogenic drugs have a firmly established position; hundreds of articles attest to the growing interest in their psychotomimetic activity. As an adjunct to psychotherapy, however, their potential has been incompletely investigated. The initial mention of lysergic acid diethylamide (LSD-25) in this connection appears to be the 1950 publication by Busch and...
Archives of Neurology And Psychiatry
March 1, 1959
Elliot D. Luby
920 citations
Introduction The production of model psychoses has been employed as a technique for testing hypotheses relevant to the causes, correlates, and treatment of schizophrenia since 1921, when De Jong demonstrated experimental catatonia by giving bulbocapnine to animals.5This method of study has received considerable impetus with the discovery of the hallucinogenic properties of lysergic acid...
Archives of Neurology And Psychiatry
October 1, 1958
A. B. Silverstein
30 citations
I. MemoryIntroduction. —The results of previous studies of the effect of lysergic acid diethylamide (LSD-25) on memory suggest that the minimal dose level at which impairment becomes evident lies somewhere between 50μg. and 100μg. Sloane and Lovett Doust,1working at the 40μg. level, and Jarvik et al.,2working at the 50μg. level, found little or no evidence of memory impairment in their studies....
Archives of Neurology And Psychiatry
June 1, 1958
Julia T. Apter
9 citations
Adventitious findings in this laboratory indicate that lysergic acid diethylamide (LSD-25) protects cats against the toxic effects of large doses of pentobarbital. One hundred forty cats have survived inordinate amounts of pentobarbital at the termination of experiments in which LSD-25 solution was given systemically. Gastaut,13Bradley,3,4and others6,8,14,18provide electrophysiological evidence...
Archives of Neurology And Psychiatry
July 1, 1956
Santo Salvatore
29 citations
Introduction Since the Swiss chemist Hoffman, on April 16, 1943, accidentally discovered the mental effects of lysergic acid diethylamide (LSD-25), a great many experiments with the drug have been reported in various journals. Observations show most agreement in the area of physical subjective symptoms and unreality and least agreement in changes of mood and behavior. Tremor, nausea, dilation...
Archives of Neurology And Psychiatry
June 1, 1956
Bert E. Schwarz
49 citations
In a recent report concerning the reversibility by chlorpromazine of psychoses induced by means of mescaline andd-lysergic acid diethylamide (LSD-25), careful attention was given to the clinical and electroencephalographic changes.1Although the clinical changes of this reversal effect were immediate and striking, the conventional electroencephalographic changes were minimal, and it was...
Archives of Neurology And Psychiatry
1956
Edward V. Evarts
52 citations
INTRODUCTION Bufotenine (5 -hydroxy -3 -[2- dimethyl-aminoethyl]-indole) is the N-dimethyl derivative of the vasoconstrictor substance serotonin (5-hydroxytryptamine). It was first synthesized by Wieland in 1934. Raymond-Hamet found that intravenous injection of bufotenine caused transient elevation of blood pressure and apnea, followed by tachypnea, in anesthetized dogs.* To date, however,...
Archives of Neurology And Psychiatry
May 1, 1951
Gordon R. Forrer
66 citations
STOLL1studied the effects of lysergic acid diethylamide (LSD-25) in both psychotic and normal subjects. Condrau2and others reported their results of administration of lysergic acid diethylamide to various types of subjects and in general confirmed the findings of Stoll. For details of the chemistry of the ergot alkaloids, we refer to a more recent, comprehensive work by Stoll.3It should be...
Archives of Neurology And Psychiatry
1941
W. S. Maclay
25 citations
The various theories about the cause of hallucinations have been largely influenced by the material which the writers studied. Thus, Mayer-Gross formed his theory on observation of the fantom limb, Schroeder on observation of delirious states and Vogt on experience with electrical stimulation of the cerebral cortex. It lies in the nature of the subject that its study is based mainly on verbal...