A M A Archives of Neurology & Psychiatry
September 1, 1958
B Weiss
8 citations
Although it is known that lysergic acid diethylamide (LSD-25) enters the brain, the mechanism by which LSD-25 acts to produce the psychotic patterns in man is unknown. Experiments which are designed to investigate the brain process in the intact animal might lead to a concept that could be developed to study the chemical process originating or connected with clinically occurring schizophrenia....
A M A Archives of Neurology & Psychiatry
May 1, 1958
Robert S. Liebert
30 citations
This study is one of a series of experiments designed to inquire into some of the perceptual effects of administration of lysergic acid diethylamide (LSD-25)* to schizophrenics and normal adults. Specifically, the study deals with the effect of LSD on size perception of one's own body and objects in space. This problem is approached within the framework of organismic behavior theory, viz., the...
A M A Archives of Neurology & Psychiatry
February 1, 1958
Theodore Greiner
47 citations
Despite 14 years of investigation, as intensive as accorded any biologically active chemical, a gap remains in the systematic description of human response to lysergic acid diethylamide (LSD-25). The dramatic schizophrenic-like symptoms after doses of 40μg to 100μg have drawn the main interest. The threshold for activity is placed at 20μg by general consensus, while perfunctory administration...
A M A Archives of Neurology & Psychiatry
February 1, 1958
Harold A. Abramson
31 citations
A. Introduction It has been shown1,2that 2 mg. of crude beef brain extract per milliliter of water blocks the usual effect of 2μg of LSD-25 per milliliter in the outside liquid on the Siamese fighting fish.* The experiments to be reported here are the study of a blocking effect probably produced by another mechanism: the development of tolerance3to LSD-25 in man by the prior administration for...
A M A Archives of Neurology & Psychiatry
December 1, 1957
Lincoln D. Clark
19 citations
One consequence of the recent interest in psychotomimetic drugs has been a search for pharmacological agents that will "block" drug-induced psychological disturbances and hallucinations. Fabing1reported that azacyclonol (Frenquel) in small doses prevented the occurrence of lysergic acid diethylamide (LSD-25) "psychoses" in man, although one of us (L. D. C.) was unable to verify this...
A M A Archives of Neurology & Psychiatry
September 1, 1957
William K. Boardman
21 citations
Introduction Much of the interest in lysergic acid diethylamide (LSD) is due to its capacity to produce schizophrenic-like behavior when administered in extremely small quantities. 4,6 Among the reported changes resulting from LSD have been alterations in time perception. DeShon, Rinkel, and Solomon, 1 found changes in the form of experiences of acceleration, retardation, or nonexistence of...
A M A Archives of Neurology & Psychiatry
April 1, 1957
Harris Isbell
50 citations
The effects of drugs on the abnormal mental state induced by the diethylamide of lysergic acid (LSD-25) are of interest from several points of view. Some means of mitigating too severe a reaction is needed in using LSD-25 experimentally or therapeutically. Since the LSD reaction is measurable and reproducible,1it might be possible to use the LSD psychosis as a screen for predicting the...
A M A Archives of Neurology & Psychiatry
February 1, 1957
Robert S. Liebert
23 citations
This study is concerned with the effect of change in organismic state, induced by a pharmacological agent, upon spatial localization. Aside from the current concern with the psychological effects induced by the drug, d -lysergic acid diethylamide (LSD-25)* the problem has its roots in two lines of investigation: 1. Studies of perception viewed in terms of an organismic theory of behavior, viz.,...
A M A Archives of Neurology & Psychiatry
November 1, 1956
Harris Isbell
112 citations
The striking mental changes induced by the diethylamide of lysergic acid (hereafter referred to as LSD) have been studied extensively in Europe,* Great Britain,† and the United States.‡ In minute doses (20γ to 120γ) LSD induces a peculiar mental state characterized by anxiety, signs of autonomic dysfunction, perceptual distortion (chiefly visual), alterations in mood and affect, synesthesias,...
A M A Archives of Neurology & Psychiatry
June 1, 1956
Nicholas A. Bercel
35 citations
INTRODUCTION Experimental psychosis has a long history. It might have started with the administration of Cannabis indica boiling in wine to the ancient Hun warriors, resulting in mental obfuscation, as they were prepared for surgery because of wounds sustained in battle. Scientific experimental psychiatry began toward the end of the last century, in the Kraepelinian era—when the organic theory...
A M A Archives of Neurology & Psychiatry
1956
Bert E. Schwarz
49 citations
Feldberg and Sherwood's* previous studies of the behavior of cats after the intraventricular injection of various drugs opened up a new method of investigation. By this technique they showed that drugs injected into this area of high pharmacologic sensitivity could evoke various complex behavioral responses and conditions resembling sleep, anesthesia, profound muscular weakness, catatonia, and...