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The History of MDMA June 29, 2023 Torsten Passie
Abstract In the 1920s, physicians discovered the potential for ‘speech induction’ offered by psychoactive substances. The German Nazis were the first to conduct experiments on the use of ‘truth drugs’ for interrogation purposes. Later, after some American prisoners of war ‘confessed’ to the use of biological weapons in the Korean war, the United States (US) Army suspected that they had been...
The MIT Press eBooks June 29, 2023 Dyck, Erika 1975-, Chris Elcock 4 citations
The first collection of its kind to explore the diverse and global history of psychedelics as they appealed to several generations of researchers and thinkers. Expanding Mindscapes offers a fascinatingly fluid and diverse history of psychedelics that stretches around the globe. While much of the literature to date has focused on the history of these drugs in the United States and Canada,...
Psychiatric News June 28, 2023 Terri D’arrigo
Back to table of contents Previous article Next article Annual MeetingFull AccessExperts Offer Tips on Talking With Patients About PsychedelicsTerri D’ArrigoTerri D’ArrigoSearch for more papers by this authorPublished Online:28 Jun 2023https://doi.org/10.1176/appi.pn.2023.07.7.51AbstractPsychedelics differ from one another in their mechanism of action and potential effects on the body and mind....
Frontiers in Psychiatry June 26, 2023 Simon Zhornitsky, Henrique Nunes Pereira Oliva, Laura A. Jayne et al. 12 citations
Background Ketamine and psychedelics have abuse liability. They can also induce “transformative experiences” where individuals experience enhanced states of awareness. This enhanced awareness can lead to changes in preexisting behavioral patterns which could be beneficial in the treatment of substance use disorders (SUDs). Preclinical and clinical studies suggest that ketamine and psychedelics...
Behavioural Brain Research June 25, 2023 Rodolpho Pereira de Oliveira, Thaís S. Yokoyama, Lucas de Santana Cardoso Thomaz et al. 2 citations
The relationship between serotonin dysfunction and schizophrenia commenced with the discovery of the effects of lysergic acid diethylamide (LSD) that has high affinity for 5-HT2A receptors. Activation of these receptors produces perceptual and behavioural changes such as illusions, visual hallucinations and locomotor hyperactivity. Using prepulse inhibition (PPI) of the acoustic startle, which...
Health Sciences June 22, 2023 Rapolas Šalaševičius, Gabrielė Pakriaušytė
Klasikiniai psichodelikai – tai natūralios (psilocibinas) arba sintetinės (LSD) medžiagos, stimuliuojančios 5-HT2A receptorius ir sukeliančios pakitusias regos, klausos, kognityvines ar nuotaikos būsenas. Šios medžiagos vis dažniau patraukia mokslo tyrėjų bendruomenės dėmesį dėl jų potencialios naudos pacientams, sergantiems įvairaus spektro psichikos sutrikimais. Atlikę literatūros apžvalgą...
Der Nervenarzt June 19, 2023 Michael Soyka 1 citation
HintergrundPilzen kommt bei Intoxikationen eine große Bedeutung zu, wobei psychiatrische Aspekte oft kaum Erwähnung finden [21,22].Die Häufigkeit des Konsums halluzinogener Pilze in Europa ist noch niedrig mit einer 12-Monats-Prävalenz von maximal 1 % [2, 5, 8-11].Für Deutschland wurde sie mit immerhin 0,5 % (Männer 0,7 %, Frauen 0,4 %) angegeben [20].Gmel et al. [6] fanden für die Schweiz aber...
Science Advances June 14, 2023 Leor Roseman, Christopher Timmermann, Daniel Golkowski et al. 65 citations
To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating the regional distribution of 19 neurotransmitter receptors and transporters...
Science June 9, 2023 Cathleen O'Grady 2 citations
LSD and psilocin molecules bind to antidepressant drug targets in the brain, study shows.
June 4, 2023 Vince Polito, Paul Liknaitzky 2 citations preprint
Some recent research and commentary have suggested that most or all the effects reported by people who microdose psychedelics may be explained by expectations or placebo effects. Here we step through all the available evidence from dose-controlled studies that have investigated the effects of low doses of LSD and psilocybin. We suggest eight reasons why current claims that microdosing is...