Journal of Mental Science
October 1, 1958
J. C. Brengelmann
10 citations
The present analysis pertains to the experiment reported by Brengelmann, Pare and Sandler (15) to assess the effect of 5-hydroxytryptophan (5-HTP) on lysergic acid diethylamide (LSD) by means of psychological tests. In the following, problems of measurement and validity of the LSD- “psychosis” are discussed.
European Journal of Endocrinology
October 1, 1958
A. C. J. Burgers, W. Leemreis, Tadeusz Dominiczak et al.
18 citations
In the last ten years the psychic actions of the drug D-lysergic acid diethylamide LSD-251, delysid (Sandoz Ltd, Basle)] have been extensively studied in man and other mammals. Little work, however, has been done on its action in lower Vertebrates. It was found that in fishes and amphibians the influence of LSD manifests itself in both behaviour- and colour-changes. Besides characteristic...
Archives of Neurology And Psychiatry
October 1, 1958
A. B. Silverstein
30 citations
I. MemoryIntroduction. —The results of previous studies of the effect of lysergic acid diethylamide (LSD-25) on memory suggest that the minimal dose level at which impairment becomes evident lies somewhere between 50μg. and 100μg. Sloane and Lovett Doust,1working at the 40μg. level, and Jarvik et al.,2working at the 50μg. level, found little or no evidence of memory impairment in their studies....
Journal of Mental Science
October 1, 1958
J. C. Brengelmann, C. M. B. Pare, M. Sandler
31 citations
In the investigation described, the hypothesis was tested that 5-hydroxytryptamine (5HT) acts to reduce the psychological effects of lysergic acid diethylamide (LSD). The method was to inject 5-hydroxytryptophan (5HTP) prior to LSD and to compare the results of psychological tests performed after these injections. Placebo controls were used.
A M A Archives of Neurology & Psychiatry
September 1, 1958
B Weiss
8 citations
Although it is known that lysergic acid diethylamide (LSD-25) enters the brain, the mechanism by which LSD-25 acts to produce the psychotic patterns in man is unknown. Experiments which are designed to investigate the brain process in the intact animal might lead to a concept that could be developed to study the chemical process originating or connected with clinically occurring schizophrenia....
Experimental Biology and Medicine
June 1, 1958
E. Costa, G. Zetler
7 citations
10 γ/kg i.p. of LSD potentiate the adrenal ascorbic acid depletion caused in rats by 25 γ/kg i.p. of epinephrine, 40 γ/kg i.p. of BOL are ineffective in this respect. 30 γ/kg i.p. of both serotonin and bufotenin potentiate the effects of epinephrine (25 γ/kg i.p.). The threshold doses of bufotenin and serotonin enhancing the epinephrine induced contractions of cat's nictitating membrane were...
Archives of Neurology And Psychiatry
June 1, 1958
Julia T. Apter
9 citations
Adventitious findings in this laboratory indicate that lysergic acid diethylamide (LSD-25) protects cats against the toxic effects of large doses of pentobarbital. One hundred forty cats have survived inordinate amounts of pentobarbital at the termination of experiments in which LSD-25 solution was given systemically. Gastaut,13Bradley,3,4and others6,8,14,18provide electrophysiological evidence...
Annals of Internal Medicine
May 1, 1958
Nicholas T. Richards, Latasha Chapman, H Goodell et al.
16 citations
Case Reports1 May 1958LSD-LIKE DELIRIUM FOLLOWING INGESTION OF A SMALL AMOUNT OF ITS BROM ANALOG (BOL-148)NELSON RICHARDS, LORING F. CHAPMAN, HELEN GOODELL, HAROLD G. WOLFF, F.A.C.P.NELSON RICHARDSSearch for more papers by this author, LORING F. CHAPMANSearch for more papers by this author, HELEN GOODELLSearch for more papers by this author, HAROLD G. WOLFF, F.A.C.P.Search for more papers by...
A M A Archives of Neurology & Psychiatry
May 1, 1958
Robert S. Liebert
30 citations
This study is one of a series of experiments designed to inquire into some of the perceptual effects of administration of lysergic acid diethylamide (LSD-25)* to schizophrenics and normal adults. Specifically, the study deals with the effect of LSD on size perception of one's own body and objects in space. This problem is approached within the framework of organismic behavior theory, viz., the...
A M A Archives of Neurology & Psychiatry
February 1, 1958
Harold A. Abramson
31 citations
A. Introduction It has been shown1,2that 2 mg. of crude beef brain extract per milliliter of water blocks the usual effect of 2μg of LSD-25 per milliliter in the outside liquid on the Siamese fighting fish.* The experiments to be reported here are the study of a blocking effect probably produced by another mechanism: the development of tolerance3to LSD-25 in man by the prior administration for...