Experimental Biology and Medicine
2020
Megan E Beerse, Theresa van Lith, Scott M. Pickett et al.
Mindfulness-based art therapy (MBAT) combines mindfulness practices with art therapy to promote health, wellness, and adaptive responses to stress. Mindfulness-based stress reduction programs have been demonstrated to reduce anxiety symptoms in people with generalized anxiety disorder and serious medical conditions such as cancer. However, the benefits of MBAT specifically—not just in clinical...
Experimental Biology and Medicine
September 1, 1971
S. K. Quadri, J. Meites
7 citations
SummaryA single ip injection of 25, 50, or 100 μg of LSD (lysergic acid diethylamide)/100 g of body weight into female rats on the morning of proestrus significantly decreased serum prolactin levels, and prevented the normal rise observed in control rats on the afternoon of proestrus. The 100-μg dose of LSD produced a significantly greater decrease in serum prolactin than the 25-μg dose. This...
Experimental Biology and Medicine
August 1, 1968
K. L. Yielding, H. Sterglanz
23 citations
SummaryAddition of DNA (but not RNA) to solutions of lysergic acid diethylamide resulted in a depression of the absorption and fluorescence spectra of the drug. The Kd for D-LSD: DNA binding, calculated from spectral changes, was 5 × 10-4 M, and each nucleotide residue was a potential binding site. Binding did not occur at pH 3 (where DNA is nonhelical), and was decreased by prior heating of...
Experimental Biology and Medicine
November 1, 1961
Charles Hamilton, Chester R. Wilpizeski
13 citations
Suppression of food intake in the rat was shown to follow injection of LSD-25 and this effect was determined to be dose dependent. When the effects of 10 daily injections of the drug were investigated, a suppression of food intake on each day indicated a lack of development of complete tolerance. These data show that caution is needed in interpretation of the behavioral effects of LSD-25 where...
Experimental Biology and Medicine
April 1, 1961
R. S. de Ropp, E. H. Snedeker
30 citations
1. Effect of electroshock and 18 chemical agents (pentylenetetrazole, semicarbazide, strychnine, picrotoxin, caffeine, pheniprazine, amphetamine, mescaline, LSD, phenobarbital, chloral hydrate, acetazolamide, diphenylhydantoin, meprobamate, chlorpromazine, methoxypromazine, reserpine and morphine) was determined on the level of 10 ninhydrin-reacting compounds in the rat brain (glutathione,...
Experimental Biology and Medicine
1961
A. Horita, L. J. Weber
49 citations
SummaryIncubation of psilocybin with purified intestinal phosphatase resulted in liberation of psilocin and inorganic phosphate. Psilocin formed was determined both quantitatively by a specific colorimetric method employing the nitrosonaphthol reagent and qualitatively by paper chromatography. Some characteristics of the phosphatase action on psilocybin are described. The possibility of a...
Experimental Biology and Medicine
November 1, 1960
John R. Bergen, Donald M. Krus, Gregory Pincus
13 citations
A series of 15 steroid hormones and metabolites were tested for their effectiveness to suppress LSD-25 induced behavior changes in rats. All produced significant suppression (p<0.05) except estradiol. Ability to suppress LSD-25 action does not appear to be related to specific molecular groups or to hormonal potency.
Experimental Biology and Medicine
July 1, 1958
Nicholas P. Plotnikoff, Helen Washington
7 citations
1. It has been demonstrated that chlorpromazine, perphenazine, proclorperazine, promazine, thiopropazate, promethazine and reserpine are effective antagonists of mescaline-induced mortality in CF1 mice. 2. No significant protection was found with use of sodium phenobarbital, meprobamate, benactyzine, atropine, hydroxyzine, ethoxybutamoxane, SY-21, diphenylhydantoin, trimethadione, lysergic acid...
Experimental Biology and Medicine
June 1, 1958
E. Costa, G. Zetler
7 citations
10 γ/kg i.p. of LSD potentiate the adrenal ascorbic acid depletion caused in rats by 25 γ/kg i.p. of epinephrine, 40 γ/kg i.p. of BOL are ineffective in this respect. 30 γ/kg i.p. of both serotonin and bufotenin potentiate the effects of epinephrine (25 γ/kg i.p.). The threshold doses of bufotenin and serotonin enhancing the epinephrine induced contractions of cat's nictitating membrane were...
Experimental Biology and Medicine
1958
E. B. Sigg, G. Caprio, J. A. Schneider
78 citations
(1) Reserpine antagonizes the analgesia in mice induced by morphine, meperidine and codeine. (2) Five-hydroxytryptophane, 5-hydroxytryptamine, tryptamine, amphetamine, mescaline and epinephrine prolong and enhance morphine analgesia whereas iproniazid and choline-p-tolyl-ether fail to do so. (3) Possible mechanisms involved in the synergistic action of amines and the antagonistic action of...
Experimental Biology and Medicine
March 1, 1957
Parkhurst A. Shore, B.b. Brodie
60 citations
1. Administration of reserpine to rabbits pretreated with the monoamine oxidase inhibitor, iproniazid, causes excitation and sympathomimetic effects similar to those observed after administration of LSD or high doses of 5-hydroxytryptophan. These effects are associated with the presence of a high concentration of free serotonin in the brain. The observations are consistent with the concept that...
Experimental Biology and Medicine
June 1, 1956
F. M. Sturtevant, Victor A. Drill
15 citations
Mescaline, injected intravenously and intraperitoneally into dogs and cats and into the lateral ventricle of the brain of cats, produced acute autonomic effects followed by catatonia. These responses appeared to be altered or prevented by pretreatment with the ataraxic agents chlorpromazine, reserpine, and azacyclonol.
Experimental Biology and Medicine
1956
E. Costa
64 citations
SummaryTranquilizing drugs: Frenquel (0.8 mg/1), chlorpromazine (0.1 mg/1) and reserpine (0.4 mg/1), antagonize serotonin-induced uterine contractions, though they do not affect sensitivity of the uterus of the spayed rat either to ACh or oxytocin. The period of antagonism is longer lasting with reserpine than with chlorpromazine and is shortest with Frenquel. Mescaline (0.1 mg/1) causes a...