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Science

ISSN 0036-8075, 1095-9203

125 papers in the library · 19,092 citations · publishing 1954-2026

Papers

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Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.

Science September 3, 2026 Mario Heles, Lilach Pasvolsky, Hinduja Sathishkumar et al.

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment. In this work, we show that as little as two doses of psilocybin before chemotherapy durably prevented the onset of CIPN across platinum- and taxane-based models, including repeated chemotherapy cycles,...

DOI: 10.1126/science.aec6116 (opens in new tab) Full text (opens in new tab)

Enhanced ERK activity extends ketamine's antidepressant effects by augmenting synaptic plasticity.

Science May 8, 2025 Z Zack Ma, Natalie J Guzikowski, Ji-Woon Kim et al. 44 citations

Repeated ketamine treatment to maintain a rapid antidepressant effect can lead to side effects over time, highlighting an unmet clinical need for sustaining this drug's antidepressant action from a single administration. Ketamine-induced synaptic potentiation at CA3-CA1 synapses has been proposed to be a key synaptic substrate for antidepressant action. Here, we found that ketamine-induced...

DOI: 10.1126/science.abb6748 (opens in new tab) Full text (opens in new tab) Depression Ketamine therapy Mental health treatment Brain chemistry

Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop.

Science April 4, 2025 Zepeng Fang, Yuanyuan Dang, An'An Ping et al. 45 citations

Human high-order thalamic nuclei activity is known to closely correlate with conscious states. However, it is not clear how those thalamic nuclei and thalamocortical interactions directly contribute to the transient process of human conscious perception. We simultaneously recorded stereoelectroencephalography data from the thalamic nuclei and prefrontal cortex (PFC), while patients with...

DOI: 10.1126/science.adr3675 (opens in new tab) Full text (opens in new tab)

Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states.

Science November 15, 2024 Jessie Muir, S Lin, Isak K Aarrestad et al. 37 citations

Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the specific neurons modulated by a psychedelic to determine their role in driving behavior. Using a light- and calcium-dependent activity integrator, we genetically tagged psychedelic-responsive neurons in...

DOI: 10.1126/science.adl0666 (opens in new tab) Full text (opens in new tab)

Psychedelic research at a crossroads

Science September 19, 2024 Stacey B. Armstrong, Alan K. Davis 6 citations

There is an urgent need to develop better treatments for mental health conditions that affect one in every eight people in the world. To combat this concern, psychedelic drugs have been combined with psychotherapy and studied in clinical trials in the United States and Europe. Psychedelics are hallucinogenic drugs that alter brain activity and facilitate altered states of consciousness. The...

DOI: 10.1126/science.adt1024 (opens in new tab) Psilocybin MDMA Hallucinogen Clinical trial +2

Brain region-specific action of ketamine as a rapid antidepressant.

Science August 9, 2024 Min Chen, Shuangshuang Ma, Hanxiao Liu et al. 87 citations

Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor (NMDAR), it was not clear whether there is a selective, primary site for ketamine's antidepressant action. We found that ketamine injection in depressive-like mice specifically blocks NMDARs in lateral habenular...

DOI: 10.1126/science.ado7010 (opens in new tab) Full text (opens in new tab) Depression treatment Ketamine therapy Brain research Psychopharmacology

AlphaFold2 structures guide prospective ligand discovery

Science May 16, 2024 Jiankun Lyu, Nicholas J. Kapolka, Ryan H. Gumpper et al. 145 citations

AlphaFold2 (AF2) models have had wide impact but mixed success in retrospective ligand recognition. We prospectively docked large libraries against unrefined AF2 models of the σ 2 and serotonin 2A (5-HT2A) receptors, testing hundreds of new molecules and comparing results with those obtained from docking against the experimental structures. Hit rates were high and similar for the experimental...

DOI: 10.1126/science.adn6354 (opens in new tab) Full text (opens in new tab) Docking animal Computational biology Affinities Stereochemistry +5