TWO animal experiments have indicated that relatively large doses of lysergic acid diethylamide (LSD) can produce changes in central nervous system (CNS) function which persist for periods of time considerably longer than are usually estimated as necessary for drug detoxication. Adey1reports cats given a single dose of LSD in amounts of 80µg/kg showed disruption of conditioned responses and...
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, controlled research of the effects of the drug in psychotherapy and in five black-market LSD users who volunteered to take pure LSD in a research setting. Statistical analysis revealed no significant difference between the before- and after-LSD...
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, controlled research of the effects of the drug in psychotherapy and in five black-market LSD users who volunteered to take pure LSD in a research setting. Statistical analysis revealed no significant difference between the before- and after-LSD...
In a single-blind study chromosome analyses were performed on three groups of subjects: 1) nine heavy users of LSD-25 who have continued to use the drug; 2) eight heavy users of LSD-25 who have ceased to use it; and 3) eight drug-free control subjects. The results revealed no significant differences in chromosome break-age rates between any of the three groups and therefore no temporal factor...
Abstract Infrared spectra of LSD and its tartrate salts, and factors affecting their reproducibility, have been investigated. Spectra corresponding to amorphous and crystalline forms of LSD base, the neutral tartrate and two forms of the hydrogen tartrate were obtained. The neutral tartrate was found to undergo conversion to the hydrogen tartrate on long standing. Comparison with spectra of...
The authors outline some of the problems involved in making a determination of legal insanity when a crime is committed following the use of LSD. Three cases of murder known to be associated with the use of LSD are described, one of them involving an individual examined personally by the authors. Five specific criteria that the authors have found to be useful aids in forensic examinations of...
Flashbacks are returns of imagery for extended periods after the immediate effect of hallucinogens has worn off. The most symptomatic form is recurrent intrusions of the same frightening image into awareness, without volitional control. The author compares flashbacks with other clinical phenomena; he believes that psychotherapy is helpful, especially if there is a focus on the traumatic and...
Ninety-five alcoholic patients took part in a single-blind study of the efficacy of LSD treatment, which featured four treatment groups: LSD given with and without a therapist present, sodium amobarbital-methamphetamine hydrochloride given with a therapist present, and routine clinic care. At one-year follow-up, with 87 percent of the patients reporting, all groups showed significant...
One hundred seventy-six male alcoholic patients participated in a controlled investigation of the differential efficacy of three LSD treatment procedures and a "no therapy," or milieu treatment, condition. Half of each group was also assigned to disulfiram after discharge from the hospital to determine whether any of these techniques could be enhanced by its use. Although significant...
14 C-lysergic acid diethylamide administered intravenously passed in a few minutes from the blood into the tissues. In addition to the brain, the adrenals, hypophysis, kidneys, liver, and lungs showed the highest uptake, much higher than the blood concentration. Excretion into the bile started immediately; this was the most important elimination route. In the early stage of pregnancy, 2.5...