Page 82 of 282: studies 811 to 820 of 2,815, newest first. Back to the LSD overview
Science September 6, 1968 Luolin S. Browning 29 citations
d-Lysergic acid diethylamide causes a significant increase in recessive lethal mutations in the X chromosome of Drosophila males after intraperitoneal injection of massive doses.
Clinical Pharmacology & Therapeutics September 1, 1968 John G. Wagner, George K. Aghajanian, O. Bing 61 citations
Previously published plasma concentrations of LSD‐25, observed following intravenous iniection of 2 mcg. per kilogram of LSD‐25, have been found to be explained by the two‐compartment open model. Performance scores on arithmetic tests were shown to be highly linearly correlated with the concentration in the “tissue” (outer) compartment. The estimated volume of the plasma (inner) compartment was...
British Journal of Pharmacology September 1, 1968 N.‐e. Andén, H. Corrodi, Kjell Fuxé et al. 274 citations
Lysergic acid diethylamide (LSD) and the 5‐hydroxytryptamine (5‐HT) precursor, 5‐hydroxytryptophan produced similar functional effects in rat spinal cord and brain to the 5‐hydroxytryptamine precursor 5‐hydroxytryptophan, which indicates that LSD stimulates central 5‐HT receptors. By means of combined histochemical and biochemical techniques it was found that LSD reduced the turnover rate of...
American Journal of Psychiatry September 1, 1968 J. Thomas Ungerleider, Duke D. Fisher, Stephen R. Goldsmith et al. 44 citations
The authors surveyed a sample of psychiatrists, psychiatric residents, internists, general practitioners, and psychologists in Los Angeles County to determine the number of patients with adverse LSD reactions seen by these professionals during an 18-month period. Over 2,000 adverse reactions were reported on, and the authors regard this as a conservative estimate. Although many clinicians feel...
American Journal of Psychiatry September 1, 1968 K. H. Blacker, Reese T. Jones, George C. Stone et al. 85 citations
Twenty-one paid volunteers who were chronic users of LSD were interviewed and participated in a series of cognitive and perceptual tests and EEG studies. Among other observations derived from both interviews and testing, the authors noted that the group shared a set of magical-mystical beliefs and profound nonaggressive attitudes, as well as a unique sensitivity to certain types of sensory...
Science August 16, 1968 George K. Aghajanian, Warren E. Foote, Michael H. Sheard 406 citations
Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased...
Experimental Biology and Medicine August 1, 1968 K. L. Yielding, H. Sterglanz 23 citations
SummaryAddition of DNA (but not RNA) to solutions of lysergic acid diethylamide resulted in a depression of the absorption and fluorescence spectra of the drug. The Kd for D-LSD: DNA binding, calculated from spectral changes, was 5 × 10-4 M, and each nucleotide residue was a potential binding site. Binding did not occur at pH 3 (where DNA is nonhelical), and was decreased by prior heating of...
Archives of Internal Medicine August 1, 1968 65 citations
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Science June 21, 1968 Robert S. Sparkes, John Melnyk, Louis P. Bozzetti 63 citations
Chromosome studies of persons exposed to lysergic acid diethylamide, either self-administered or received during medical therapy, failed to demonstrate significant chromosomal damage.
Science June 14, 1968 Niels E. Skakkebæk, J. Philip, Ole J. Rafaelsen 62 citations
Meiotic chromosomes of six mice injected with high doses of lysergic acid diethylamide (LSD-25) and of six controls were studied. Several breaks, gaps, and unidentifiable fragments were found in the treated but, with a few exceptions, not in the control animals. Secondary constrictions were more numerous in the treated than in the untreated mice. Possible consequences are discussed.