Annals of Internal Medicine
November 1, 1967
Kurt Hirschhorn, Maimon M. Cohen
2 citations
Editorials1 November 1967Nonpsychic Effects of Lysergic Acid DiethylamideKURT HIRSCHHORN, M.D., MAIMON M. COHEN, PH.D.KURT HIRSCHHORN, M.D.Search for more papers by this author, MAIMON M. COHEN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-5-1109 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack...
Archives of General Psychiatry
November 1, 1967
William H. Mcglothlin
118 citations
THIS IS A report of a study designed to measure personality, attitude, value, interest, and performance changes resulting from the administration of LSD to normals. Several investigators using LSD with humans in nontherapy experiments have observed that some of their subjects report various lasting effects attributable to the drug experience. 1,2 In addition, the recent controversy over the...
Science
October 27, 1967
William D. Loughman, Thornton W. Sargent, David M. Israelstam
94 citations
Leukocyte cultures from eight human subjects who had had recent exposure to large doses of lysergic acid diethylamide were examined for chromosome abnormalities. The number of abnormalities was not significantly greater than that in control cultures.
Science
October 13, 1967
William F. Geber
87 citations
Malformations of the brain, spinal cord, liver, and other viscera; body edema; and localized hemorrhages were found in fetal hamsters from mothers injected subcutaneously with a single dose of mescaline, lysergic acid diethylamide, or 2-bromo-D lysergic acid diethylamide on the 8th day of pregnancy. In addition, all three drugs produced an increase in the percentages of small fetuses per...
Science
September 22, 1967
Thomas N. Chase, George R. Breese, Irwin J. Kopin
1 citation
Slices of rat brain which had accumulated tritiated serotonin either in vivo or in vitro were superfused and electrically stimulated. There occurred a marked release of the exogenous amine and, to a lesser extent, its deaminated metabolites, which varied with the region of brain tested and was inhibited by lysergic acid diethylamide.
Science
September 15, 1967
Robert Auerbach, James A. Rugowski
96 citations
Injection of lysergic acid diethylamide tartrate into mice in early pregnancy caused a 57 percent incidence of grossly abnormal embryos.
JAMA
September 11, 1967
Doris H. Milman
18 citations
A 5-year-old girl with an apparently normal premorbid personality and adjustment became acutely psychotic following a single accidental ingestion of 100μg of d-lysergic acid diethylamide (LSD), with agitation, panic, depression and flattening of affect, disorientation, feelings of depersonalization, distortion of body image, and depression of intellectual functioning. In addition she displayed...
Science
July 21, 1967
S. T. Irwin, José Egozcue
139 citations
A significant increase of chromosomal abnormalities was found in leukocytes from LSD-25 users (six out of eight) compared to nonuser controls (one out of nine). The two LSD-25 users showing no damage reported the lowest estimated average dose. The subjects whose cells showed damage were tested between 1 day and 6 months after their last LSD-25 dose.
JAMA
June 19, 1967
Barry J. Materson
6 citations
THE usual oral dose (25μg to 150μg) of lysergic acid diethylamide (LSD) required for a desired psychedelic effect is far below that which causes other serious derangements directly attributable to its pharmacologic activity. Complications of the illicit oral use of the drug, despite larger doses, are also largely limited to its hallucinogenic and psychologic effect. Doses of 20μg/kg of body...
The Journal of Nervous and Mental Disease
June 1, 1967
Charles Shagass, Robert M. Bittle
24 citations
1 Temple University Medical Center and Eastern Pennsylvania Psychiatric Institute, 3300 Henry Avenue, Philadelphia, Pennsylvania, 19129. 2 Psychopathic Hospital, University of Iowa, Iowa City, Iowa.