Correlation of performance test scores with “tissue concentration” of lysergic acid diethylamide in human subiects
John G. Wagner, George K. Aghajanian, O. Bing
Clinical Pharmacology & Therapeutics September 1, 1968 DOI: 10.1002/cpt196895635 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Pharmacokinetic modeling study Peer reviewed |
|---|---|
| Dose | 2 mcg per kilogram |
| Topics | LSD |
| Keywords | Compartment ship Body weight Extracellular fluid Plasma concentration Animal science Biochemistry |
| Citations | 61 |
| Key points | The two-compartment open model explains LSD-25 plasma concentrations, and arithmetic test performance correlates linearly with tissue compartment concentration. |
Abstract
Previously published plasma concentrations of LSD‐25, observed following intravenous iniection of 2 mcg. per kilogram of LSD‐25, have been found to be explained by the two‐compartment open model. Performance scores on arithmetic tests were shown to be highly linearly correlated with the concentration in the “tissue” (outer) compartment. The estimated volume of the plasma (inner) compartment was 16.3 per cent of body weight, which is approximately the value reported for extracellular water; the estimated volume of the tissue compartment was 11.5 per cent of body weight. The estimated half‐life for loss of LSD‐25 from the plasma compartment, based on the model, was 103 minutes compared with a half‐life of 180 minutes calculated directly from plasma concentrations.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 6
- The Pharmacology of Lysergic Acid Diethylamide: A Review CNS Neuroscience & Therapeutics November 11, 2008
- Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects Clinical Pharmacokinetics February 14, 2017
- Lysergic acid diethylamide and [−]-2,5-dimethoxy-4-methylamphetamine increase extracellular glutamate in rat prefrontal cortex Brain Research August 27, 2004
- Pharmacokinetics and subjective effects of a novel oral LSD formulation in healthy subjects British Journal of Clinical Pharmacology March 19, 2019
- Metabolism of lysergic acid diethylamide (LSD): an update Drug Metabolism Reviews July 3, 2019
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