Science
May 2, 1969
J. K. Hanaway
28 citations
High doses (5 × 10- 6 gram) of LSD-25 given to Swiss-Webster females on gestation days 6, 7, 8, or 9 caused a high incidence of anterior subcapsular lens abnormalities. Accompanying this, the lens epithelium was often hyperplastic, and the lens bow was widened posteriorly in a fashion similar to cataracts induced by x-radiation. Confirmation of this effect of LSD-25 was obtained by a...
American Journal of Psychiatry
April 1, 1969
Leo E. Hollister, Jack Shelton, George Krieger
104 citations
Seventy-two alcoholic patients were admitted to a controlled comparison of LSD and dextroamphetamine as treatments. In the context of little associated psychotherapeutic intervention, LSD produced slightly better results early, but after six months the results were alike for both treatment groups. Controlled studies of such treatments are not only possible but mandatory, the authors conclude,...
Canadian Psychiatric Association Journal
February 1, 1969
C. G. Costello
5 citations
L'auteur passe en revue les études que l'on a faites sur l'emploi des stimulus en-gendrant la répugnance, ou de la diéthylamide de l'acide lysergique dans le traitement de l'alcoolisme. Ces stimulus étaient l'apomorphine, l'émétine, la scoline et le choc électrique. Rien n'indique à l'évidence que ces méthodes sont plus efficaces que les autres, non excitantes, pour traiter les alcooliques....
Science
1969
Robert C. Lin, S. H. Ngai, E. Costa
69 citations
Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of (14)C-tryptophan into (14)C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of (14)C-tryptophan conversion into (14)C-5-hydroxytryptamine. The...
JAMA
December 2, 1968
David A. Hungerford
40 citations
Chromosomes have been studied in leukocytes cultured from patients undergoing experimental therapy with lysergic acid diethylamide (LSD 25). Aberration frequencies prior to therapy were established for three of the four patients; these were comparable to frequencies in control subjects. Following each of three doses given intravenously (usually 200μg per dose), each patient's chromosomes were...
Journal of AOAC International
November 1, 1968
James Look
Abstract A method for identification and determination of lysergic acid diethylamide (LSD) was studied collaboratively by 11 collaborators on three samples prepared by the Associate Referee. The presumptive test is a valuable tool for rapid preliminary examination. Racemization of the LSD adds further to its identification by paper chromatography. Assay recovery, based on Sandoz LSD-25...
American Journal of Psychiatry
November 1, 1968
Charles Clay Dahlberg, Ruth Mechaneck, Stanley Feldstein
25 citations
An inquiry was sent to 29 investigators conducting research involving the use of LSD or other hallucinogens, in an effort to determine what effects publicity about LSD may have had upon their research. Nineteen of the investigators reported that the publicity had negatively affected the recruitment of "appropriate" subjects, the attitudes of already participating subjects, the behavior of...
The British Journal of Psychiatry
October 1, 1968
Glin Bennet
It is twenty years since the appearance of Stoll's paper: “Lysergic acid diethylamide, a hallucinatory agent of the ergot group” (23). In this he sought to reproduce in a group of subjects Hofmann's personal experiences of the drug, and so set the LSD snowball on its way. Some 1,500 papers must by now have been gathered to it; they deal with a greater range of uses than has been thought of for...
Archives of General Psychiatry
October 1, 1968
Charles Clay Dahlberg
9 citations
The history of the use of LSD in medicine follows the usual pattern for a new drug: first, speculation on its use and mechanisms following preliminary browsing research; second, exaggerated claims about its value; and third, carefully controlled trials. This book is the first in what will undoubtedly be a long list of reports on the latter category. It is important for its virtues as well as...
JAMA
September 9, 1968
Lionel Grossbard
23 citations
Acute leukemia occurred in a user of several hallucinogenic drugs (lysergic acid diethylamide [LSD], mescaline, marihuana, and amphetamines). The leukemic leukocytes of the patient contained a Ph1-like chromosome; lymphocytes transformed with phytohemagglutinin did not show chromosome breaks. A Ph1-like chromosome has only rarely been reported in either acute leukemia or in cultured lymphocytes...