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Lysergic Acid Diethylamide (LSD) Binding to Deoxyribonucleic Acid (DNA)

K. L. Yielding, H. Sterglanz

Experimental Biology and Medicine August 1, 1968 DOI: 10.3181/00379727-128-33303 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Experimental study Peer reviewed
Topics LSD
Keywords Dna Fluorescence Nucleotide Binding site Nucleic acid Biochemistry Rna
Citations 23
Key findings LSD binds to DNA with a Kd of 5 × 10⁻⁴ M, and binding depends on DNA's helical structure and is inhibited by heat or magnesium chloride.

Abstract

SummaryAddition of DNA (but not RNA) to solutions of lysergic acid diethylamide resulted in a depression of the absorption and fluorescence spectra of the drug. The Kd for D-LSD: DNA binding, calculated from spectral changes, was 5 × 10-4 M, and each nucleotide residue was a potential binding site. Binding did not occur at pH 3 (where DNA is nonhelical), and was decreased by prior heating of the DNA or by adding MgCl2 at a concentration of 3.7 × 10-3M.

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Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants 2016 Experimental study
Crystal structure of an LSD-bound human serotonin receptor 2017 Experimental study with structural biology and molecular dynamics simulations
Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin 1968 Experimental study
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain 2017 Experimental study
LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients 1973 Experimental study n = 60

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