Chromosomal Effect in vivo of Exposure to Lysergic Acid Diethylamide
Robert S. Sparkes, John Melnyk, Louis P. Bozzetti
Science June 21, 1968 DOI: 10.1126/science.160.3834.1343 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Persons exposed to lysergic acid diethylamide |
| Intervention | lysergic acid diethylamide |
| Topics | LSD |
| Keywords | In vivo Pharmacology Toxicology Genetics Biochemistry Receptor |
| Citations | 63 |
| Key findings | Exposure to lysergic acid diethylamide did not cause significant chromosomal damage. |
Abstract
Chromosome studies of persons exposed to lysergic acid diethylamide, either self-administered or received during medical therapy, failed to demonstrate significant chromosomal damage.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 7
- The Experimental Use of Psychedelic (LSD) Psychotherapy JAMA June 15, 1970
- LSD and Genetic Damage Science April 30, 1971
- LSD and Chromosomes JAMA November 3, 1969
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Cytogenetic Effects of LSD 25 Therapy in Man JAMA December 2, 1968
and 2 more in the library
Cites 4
- Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide Science March 17, 1967
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Leukocytes of Humans Exposed to Lysergic Acid Diethylamide: Lack of Chromosomal Damage Science October 27, 1967