Correlation of performance test scores with “tissue concentration” of lysergic acid diethylamide in human subiects
Clinical Pharmacology & Therapeutics September 1, 1968 John G. Wagner, George K. Aghajanian, O. Bing 61 citations
Previously published plasma concentrations of LSD‐25, observed following intravenous iniection of 2 mcg. per kilogram of LSD‐25, have been found to be explained by the two‐compartment open model. Performance scores on arithmetic tests were shown to be highly linearly correlated with the concentration in the “tissue” (outer) compartment. The estimated volume of the plasma (inner) compartment was...