Pharmacology, Biochemistry, and Behavior
February 1, 2026
Daniel A Palacios-Lagunas, Juan C Hernández-mondragón, Kjell Fuxé et al.
1 citation
The promotion of prosocial behavior is a remarkable MDMA property. Such an effect is rather uncommon among other psychoactive substances and has been proposed to be of relevance for the potential therapeutic utility of MDMA. We aim to expand our knowledge of the prosocial effects of MDMA, considering sex and housing conditions as extra variables. To this end, housed individually or...
Expert Opinion on Therapeutic Targets
April 1, 2024
Carlos Arrabal-Gómez, Pedro Serrano-Castro, Jose Andrés Sánchez-Pérez et al.
7 citations
Major Depressive Disorder (MDD) poses a significant challenge to global health, with current treatments often limited by efficacy and onset delays. This study explores the synergistic antidepressant-like effects of an NPY1R agonist and Ketamine, targeting their neurobiological interactions within the ventral hippocampus. Utilizing a preclinical model, this study administered Neuropeptide Y...
Cells
July 27, 2021
Dasiel O Borroto-Escuela, Patrizia Ambrogini, Manuel Narváez et al.
29 citations
The heteroreceptor complexes present a novel biological principle for signal integration. These complexes and their allosteric receptor–receptor interactions are bidirectional and novel targets for treatment of CNS diseases including mental diseases. The existence of D2R-5-HT2AR heterocomplexes can help explain the anti-schizophrenic effects of atypical antipsychotic drugs not only based on...
Communicative & Integrative Biology
November 1, 2011
Luigi F Agnati, Peter W Barlow, František Baluška et al.
Different theories have been put forward during the last decade to explain the functional meaning of sleep and dreaming in humans. In the present paper, a new theory is presented which, while taking advantage of these earlier theories, introduces the following new and original aspects: • Circadian rhythms relevant to various organs of the body affect the reciprocal interactions which operate to...
Palgrave Macmillan UK eBooks
1983
Sven Ove Ögren, Kjell Fuxé, Odd‐geir Berge et al.
11 citations
The present studies have shown that chronic antidepressant treatment with desipramine (DMI), imipramine (IMI) and zimelidine produced behavioral evidence for sub- and supersensitivity depending on 5-HT agonist dose and types of behavior examined. Thus, chronic treatment with all three drugs reduced head twitches induced by a high dose of the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine...
British Journal of Pharmacology
September 1, 1968
N.‐e. Andén, H. Corrodi, Kjell Fuxé et al.
274 citations
Lysergic acid diethylamide (LSD) and the 5‐hydroxytryptamine (5‐HT) precursor, 5‐hydroxytryptophan produced similar functional effects in rat spinal cord and brain to the 5‐hydroxytryptamine precursor 5‐hydroxytryptophan, which indicates that LSD stimulates central 5‐HT receptors. By means of combined histochemical and biochemical techniques it was found that LSD reduced the turnover rate of...