LSD in Mice: Abnormalities in Meiotic Chromosomes
Niels E. Skakkebæk, J. Philip, Ole J. Rafaelsen
Science June 14, 1968 DOI: 10.1126/science.160.3833.1246 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled experiment Peer reviewed |
|---|---|
| Sample size | 12 |
| Population | Mice |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Dose | high doses |
| Topics | LSD |
| Keywords | Meiosis Genetics |
| Citations | 62 |
| Key findings | High doses of LSD-25 induced chromosomal breaks, gaps, and fragments in meiotic chromosomes of treated mice compared to controls. |
Abstract
Meiotic chromosomes of six mice injected with high doses of lysergic acid diethylamide (LSD-25) and of six controls were studied. Several breaks, gaps, and unidentifiable fragments were found in the treated but, with a few exceptions, not in the control animals. Secondary constrictions were more numerous in the treated than in the untreated mice. Possible consequences are discussed.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 8
- LSD and Genetic Damage Science April 30, 1971
- Treatment of alcoholism using psychedelic drugs: a review of the program of research. Journal of Psychoactive Drugs 1998
- LSD and Chromosomes JAMA November 3, 1969
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Effect of LSD on Human Pregnancy JAMA June 1, 1970
and 3 more in the library
Cites 4
- Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide Science March 17, 1967
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
- Chromosomal Abnormalities in Leukocytes from LSD-25 Users Science July 21, 1967
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967