In an attempt to identify the factors responsible for adverse reactions to LSD and to elucidate the rising incidence of hospital admissions associated with use of the drug, the authors compared 25 psychiatric inpatients hospitalized following LSD ingestion with 25 members of a group who took LSD together regularly without reported difficulty. Although some differences were found between the...
Four cases of stramonium poisoning in teen-agers secondary to ingestion of Asthmador asthmatic powder (stramonium-belladonna mixture) presented as LSD reactions. The clinical manifestations were acute brain syndrome and physical signs of atropinization. The effects of stramonium ingestion are similar to the effects of the ingestion of amphetamine and LSD, but in addition to the psychosis due to...
An increase of chromosomal abnormalities was found in leukocytes of LSD users compared to drug-free controls. Elevated breakage rates were also found in children exposed to the drug in utero. The data showed no correlation between amount of drug per dose, number of doses, or total dosage and frequency of chromosomal breaks.
WHILE SCIENTISTS may debate the appropriate use of hallucinogens, history records our unceasing urge to cope with dreary reality or dread with the aid of magic, drugs, drama, festival rites, and (with biological regularity) through dreams. The need to transcend limits also finds a voice in utopian ideologies-be they of the inner world, of this, or the next; the promise of omnipotent mastery is...
LSD is the only new treatment for alcoholism which has been introduced in recent years; on that basis the authors justify this latest volume on LSD therapy. It gives a very brief, yet scholarly review of the neurophysiological, behavioral, and psychological effects of LSD as well as proposed mechanisms of action, assesses previous therapeutic work with LSD, weighs it in the balance, and finds...
NO drug used by man has stimulated greater public-debate than lysergic acid diethylamide (LSD). This brief review of the current status of the drug will summarize its pharmacology, medical uses and dangers. No attempt will be made to analyze in detail its alleged benefits when taken indiscriminately or under uncontrolled circumstances; these include augmented aesthetic sensitivity, enhanced...
Lysergic acid diethylamide (LSD) in doses of 1.5 to 300 micrograms was given to 55 pregnant rats during periods of organogenesis and on the 4th or 5th day of pregnancy to 34 rats. Examination of the resultant 887 young for congenital defects showed no greater frequency than in controls. These experiments failed to prove that LSD is teratogenic in rats.
1 Student Health Service, University of British Columbia, Vancouver 8, B. C, Canada; Department of Psychiatry, University of British Columbia. Paper read at the annual meeting of the North Pacific Society of Psychiatry and Neurology, Vancouver, B.C., April 6–8, 1967.
THE induction of chromosomal aberrations by exogenous agents, such as viruses, radiation and chemicals, is an area of active cytogenetic investigation.1 Recently, the psychotomimetic hallucinogen, lysergic acid diethylamide (LSD-25), has been added to the list of chemicals capable of causing abnormalities in the chromosomes of human leukocytes.2 , 3 Such preliminary studies report the in vitro...