Internet gaming disorder (IGD) is a pervasive global mental health issue, and finding effective treatments for the disorder has been challenging. Mindfulness meditation (MM), recognized for its holistic approach that involves integrating mental and physical facets, holds promise for addressing the multifaceted nature of addiction. Nevertheless, the effect of MM on IGD and its associated neural...
Studies on the electrophysiological and phenomenological aspects of dream experiences provide insight on consciousness during sleep. Whole night polysomnography (PSG) studies were conducted among 29 healthy young participants with high dream recall abilities. Dreams reports were collected during the second night by multiple awakening protocol. On the third night, participants were presented...
The default mode network (DMN) exhibits distinct dynamic and topographic features relative to the brain’s other networks, yet their link to consciousness remains unclear. We review both neural (DMN-based topography and dynamics) and mental (experience of time speed, mental time travel, and self-non-self) findings across diverse nonordinary states of consciousness, including reduced (anesthesia,...
Brain and BehaviorJune 1, 2025Alessandro Agostini, Sara Ventura, Silvia Tempia Valenta et al.
Crohn's disease (CD) is associated with psychological disorders and insecure attachment styles, potentially reflecting the long-lasting disease effect. Although functional magnetic resonance imaging (fMRI) studies revealed differences in CD patients relative to HC, the brain properties underlying the attachment dimensions in CD remain scarcely investigated. We carried out an fMRI study to...
OBJECTIVE This study investigates the impact of basal ganglia intracerebral hemorrhage (ICH) on default mode network (DMN) connectivity and its relationship with cognitive impairment using resting-state functional magnetic resonance imaging (rs-fMRI). METHOD DMN differences between left/right basal ganglia ICH patients and healthy controls were analyzed respectively. Co-altered brain region...
Abstract Background The brain’s default mode network (DMN) plays a role in social cognition, with altered DMN function being associated with social impairments across various neuropsychiatric disorders. However, the genetic basis linking sociability with DMN function remains underexplored. This study aimed to elucidate the shared genetics and causal relationship between sociability and...
Parkinson's disease (PD) has become the second most prominent neurogenerative disorder relating to aging individuals. PD involves the loss of neurons containing dopamine in the midbrain and leads to a number of motor issues as well as non-motor complications such as cognitive and psychological abnormalities. The default mode network (DMN) is a complex brain network primarily active during rest...
Introduction Research on the influence of transcranial alternating current stimulation over alpha functional connectivity (FC) is scarce, even when it poses as a potential treatment for various diseases. This study aimed to investigate the effects of individual alpha frequency tACS (IAF-tACS) on FC within the default mode network (DMN) in healthy individuals, particularly following the triple...
This viewpoint explores the therapeutic potential of psychedelics in treating neuropsychiatric disorders, particularly through the modulation of brain entropy and the experience of ego dissolution. Psychedelics disrupt rigid neural patterns, facilitating enhanced connectivity and fostering profound emotional breakthroughs that may alleviate symptoms of disorders like depression, anxiety, PTSD,...
Depressive disorders have been consistently associated with elevated levels of mind-wandering and self-focused negative rumination. Separate tracks of research have implicated brain structures within the default mode network (DMN) in both mind-wandering and depression. In this study, we hypothesized that diminished mind-wandering and fewer depressive symptoms would co-occur in individuals with...
Brain and BehaviorMay 1, 2025Seishu Nakagawa, Hikaru Takeuchi, Y. Taki et al.
Schizotypy is a personality trait characterized by subclinical expression of the signs and symptoms of schizophrenia. Maladaptive schizotypy is given the clinical designation of schizotypal personality disorder. Previous studies have shown that functional disturbance of the default mode network (DMN) is associated with maladaptive schizotypy. Working memory impairment is a particularly common...
Brain and BehaviorMay 1, 2025Linhao Zhang, Charles F. Geier, Ellen House et al.
The present study examined default mode network (DMN) neural connectivity patterns among adolescents. Next, we tested two critical markers of sleep health—duration and efficiency, in predicting neural connectivity patterns. Last, we investigated the latent DMN profiles’ predictive utility of internalizing and externalizing symptoms in youth.
BACKGROUND Neuropsychiatric symptoms (NPS) in mild cognitive impairment (MCI) are associated with accelerated Alzheimer's disease (AD) progression. Identifying multimodal brain imaging patterns associated with NPS in MCI may help understand pathophysiology correlates AD. METHODS This cross-sectional resting-state functional magnetic resonance imaging study included 376 participants: 130 MCI...
Given the increasing interest in the potential cognitive benefits of green tea, this study evaluated the efficacy of processed green tea products as nootropic agents. We conducted a 12-week, randomized, double-blinded, placebo-controlled trial to assess the effects of heat-treated green tea extract (HT-GTE) supplementation on memory performance in individuals with subjective memory impairment...
Abstract N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory distortions and visual imagery. Multimodal neuroimaging data paired with dynamic analysis techniques offer a valuable approach for identifying...
Consciousness, at its simplest, represents awareness of self in relation to the outside world. This can be divided further into the reasoning and rationality of Access consciousness (A-C) versus the experiential and 'what it's like' of Phenomenal consciousness (P-C). A-C is directly measurable, using standard tests of cognition and memory. However, owing to the subjective nature of P-C, its...
Mild Cognitive Impairment (MCI) is marked by a measurable decline in cognitive function that exceeds typical age-related changes but does not yet qualify as dementia. The brain's Default Mode Network (DMN) remains active during rest and plays a crucial role in introspective processes, such as memory retrieval and self-referential thinking. Resting-state functional magnetic resonance imaging...
Introduction Neurologic impairment is common in patients with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. While patients with severe COVID have a higher prevalence of neurologic symptoms, as many as one in five patients with mild COVID may also be affected, exhibiting impaired memory as well as other cognitive dysfunctions. Methods To characterize the effect of COVID on the...
Introduction Depression is a heterogeneous disorder with diverse clinical presentations and etiological underpinnings, necessitating the identification of distinct subtypes to enhance targeted interventions. Dissociative symptoms, commonly observed in major depressive disorder (MDD) and linked to early life trauma, may represent a unique clinical dimension associated with specific...