Pharmacology, Biochemistry, and Behavior
December 29, 2020
Sara de la Salle, Joëlle Choueiry, D. Shah et al.
N-methyl-D-aspartate receptor (NMDAR) antagonists administered to healthy humans results in schizophrenia-like symptoms, which are thought in part to be related to glutamatergically altered electrophysiological connectivity in large-scale intrinsic functional brain networks. Here, we examine resting-state source electroencephalographic (EEG) connectivity within and between the default mode...
Brain and Behavior
December 18, 2020
Zainab Sandhu, Onur Tanglay, I. Young et al.
The default mode network (DMN) is an important mediator of passive states of mind. Multiple cortical areas, such as the anterior cingulate cortex, posterior cingulate cortex, and lateral parietal lobe, have been linked in this processing, though knowledge of network connectivity had limited tractographic specificity.
Sleep
December 14, 2020
Raphael Vallat, Alain Nicolas, Perrine Ruby
Why do some individuals recall dreams every day while others hardly ever recall one? We hypothesized that sleep inertia-the transient period following awakening associated with brain and cognitive alterations-could be a key mechanism to explain interindividual differences in dream recall at awakening. To test this hypothesis, we measured the brain functional connectivity (combined...
Neuron
December 1, 2020
Jennifer D. Whitesell, Adam Liska, Ludovico Coletta et al.
Summary The evolutionarily conserved default mode network (DMN) is a distributed set of brain regions coactivated during resting states that is vulnerable to brain disorders. How disease affects the DMN is unknown, but detailed anatomical descriptions could provide clues. Mice offer an opportunity to investigate structural connectivity of the DMN across spatial scales with cell-type resolution....
medRxiv
November 27, 2020
Maria E Fini, William J. Tyler
5 citations
preprint
ABSTRACT The dorsal anterior cingulate cortex (dACC) operates as an integrator of bottom-up and top-down signals and is implicated in both cognitive control and emotional processing. The dACC is believed to be causally involved in switching between attention networks, and previous work has linked it to cognitive performance, concentration, relaxation, and emotional distraction. The present...
medRxiv Preprint Server
November 26, 2020
Giulia Bommarito, Anjali Tarun, Younes Farouj et al.
7 citations
preprint
Background Modifications in brain function remain relatively unexplored in progressive multiple sclerosis (PMS), despite their potential to provide new insights into the pathophysiology of this disease stage.
Neural Plasticity
November 23, 2020
Yan Cui, Qiao Chen, Yang Xia et al.
The default-mode network (DMN) is believed to be associated with levels of consciousness, but how the functional connectivity (FC) of the DMN changes across different states of consciousness is still unclear. In the current work, we addressed this issue by exploring the coactive micropattern (CAMP) networks of the DMN according to the CAMPs of rat DMN activity during the sleep-wake cycle and...
Neuropsychopharmacology
November 20, 2020
Felix Müller, Friederike Holze, Patrick C. Dolder et al.
43 citations
Abstract It has been reported that serotonergic hallucinogens like lysergic acid diethylamide (LSD) induce decreases in functional connectivity within various resting-state networks. These alterations were seen as reflecting specific neuronal effects of hallucinogens and it was speculated that these shifts in connectivity underlie the characteristic subjective drug effects. In this study, we...
Consciousness and Cognition
November 1, 2020
Andrew A Fingelkurts, Alexander A Fingelkurts, Tarja Kallio-Tamminen
41 citations
Recently, a three-dimensional construct model for complex experiential Selfhood has been proposed (Fingelkurts, Fingelkurts, & Kallio-Tamminen, 2016b,c). According to this model, three specific subnets (or modules) of the brain self-referential network (SRN) are responsible for the manifestation of three aspects/features of the subjective sense of Selfhood. Follow up multiple studies...
European Journal of Psychotraumatology
October 23, 2020
Ruth A. Lanius, Braeden A. Terpou, Margaret C Mckinnon
158 citations
ABSTRACT Trauma can profoundly affect the sense of self, where both cognitive and somatic disturbances to the sense of self are reported clinically by individuals with posttraumatic stress disorder (PTSD). These disturbances are captured eloquently by clinical accounts, such as, ‘I do not know myself anymore,’ ‘I will never be able to experience normal emotions again,’ and, ‘I feel dead...
Scientific Reports
October 20, 2020
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
60 citations
Retracted
Abstract Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be...
Scientific Reports
October 2, 2020
Manoj K. Doss, Darrick G. May, Matthew W. Johnson et al.
52 citations
Abstract Salvinorin A (SA) is a κ-opioid receptor agonist and atypical dissociative hallucinogen found in Salvia divinorum . Despite the resurgence of hallucinogen studies, the effects of κ-opioid agonists on human brain function are not well-understood. This placebo-controlled, within-subject study used functional magnetic resonance imaging for the first time to explore the effects of inhaled...
Consciousness and Cognition
October 1, 2020
Timothy Joseph Lane
22 citations
For millennia self has been conjectured to be necessary for consciousness. But scant empirical evidence has been adduced to support this hypothesis. Inconsistent explications of "self" and failure to design apt experiments have impeded progress. Advocates of phenomenological psychiatry, however, have helped explicate "self," and employed it to explain some psychopathological symptoms. In those...
Neuroimage
July 22, 2020
Xiao Chen, Ning-Xuan Chen, Yang-Qian Shen et al.
Rumination is a repetitive self-referential thinking style that is often interpreted as an expression of abnormalities of the default mode network (DMN) observed during "resting-state" in major depressive disorder (MDD). Recent evidence has demonstrated that the DMN is not unitary but can be further divided into 3 functionally heterogenous subsystems, although the subsystem mechanistically...
Frontiers in Integrative Neuroscience
July 8, 2020
June van Aalst, Jenny Ceccarini, Koen Demyttenaere et al.
57 citations
Yoga is becoming increasingly popular worldwide, with several implicated physical and mental benefits. Here we provide a comprehensive and critical review of the research generated from the existing neuroimaging literature in studies of yoga practitioners. We reviewed 34 international peer-reviewed neuroimaging studies of yoga using magnetic resonance imaging (MRI), positron emission tomography...
NeuroImage: Clinical
June 25, 2020
Scott A. Jones, A. Morales, A. Holley et al.
Highlights • Pain symptoms in adolescents are associated with default mode network connectivity.• More frequent pain is associated with more connectivity to the superior frontal gyrus.• Higher pain intensity is associated with less connectivity to the cerebellum.
Proceedings of the National Academy of Sciences
June 15, 2020
J. Ferrier, E. Tiran, T. Deffieux et al.
Significance Our report first validates an imaging technique, functional ultrasound, an experimental approach providing significantly higher sensitivity and spatiotemporal resolution than fMRI, for the study of sensory stimulation-induced changes in activation and connectivity patterns in the awake mouse brain. Next, by using this approach in lightly sedated conscious mice, we provide...
Journal of Clinical Sleep Medicine
June 15, 2020
Valentina Gnoni, Sean Higgins, Alexander David Nesbitt et al.
12 citations
Unpleasant dreamlike mentation can occur during non-rapid eye movement parasomnias, leading to associated panic attacks. The mentations are rarely remembered and are likely underreported. However, they may lead to significant personal distress and, if not addressed, may contribute to poorer clinical outcomes. Cotard le délire de negation are very rare nihilistic delusions, historically...
Journal of the American Academy of Child & Adolescent Psychiatry
June 12, 2020
Christian A. Webb, Elana S. Israel, Emily L. Belleau et al.
Objective: Understanding the fluctuating emotional and cognitive states of adolescents with depressive symptoms requires fine-grained and naturalistic measurements. This study used ecological momentary assessment (EMA) to investigate the affective correlates and consequences of mind-wandering in adolescents with anhedonia (AH) and typically developing (TD) controls. In addition, we examined the...
Neuroimage
June 6, 2020
Lucilla Lanzoni, Daniela Ravasio, H. Thompson et al.
Recent accounts of large-scale cortical organisation suggest that the default mode network (DMN) is positioned at the top of a principal gradient, reflecting the separation between heteromodal and unimodal sensory-motor regions in patterns of connectivity and in geodesic distance along the cortical surface (Margulies et al., 2016). This isolation of DMN from external inputs might allow the...