BACKGROUND Altered experiences of space and time are core features of schizophrenia spectrum disorders (SSD) and mood disorders (MOD). In this study, we investigated whether patients with SSD and MOD exhibit shared or distinct patterns of subjective spatiotemporal experience. METHODS We examined 62 ICD-11 patients (33 SSD, 29 MOD) using the Scale for Space and Time Experience in Psychosis...
Distinguishing between self (internal) and environment (external) is fundamental to human experience, yet mind-body traditions describe non-dual states where this boundary dissolves. However, the neural basis of non-duality remains underexplored. We investigate this in advanced and novice meditators from the Isha Yoga tradition and meditation-naïve controls using psychological scales and...
Consciousness science is fragmented, and empirical investigations are confined within each theory of consciousness’ (TOC) framework. Proliferating ToCs accumulate anomalies without progress, operating orthogonally. The principle of recurrency – functional and architectural – offers a unifying, mechanistic scaffold for consciousness to arise. We show that all theories tacitly invoke feedback...
Background Electroencephalographic (EEG) studies attempting to characterise the neural signature of meditation typically rely on contrasts with passive rest or comparisons among practitioners based on experience. However, these approaches rarely include active control states and seldom establish the reliability and robustness of identified quantitative EEG features. Consequently, the validity...
Computing can take advantage of physics-that is, 'whatever physics offers' (Jaeger et al. 2023 Nat. Commun. 14, 4911 (doi:10.1038/s41467-023-40533-1)). One of the key features physics provides is time: it describes rules and makes predictions about how activity patterns change over time, as governed by dynamics. We argue that computing can learn from physics in how it conceives time-namely, in...
Different forms of meditation, like Vipassana and Shoonya, require distinct attentional features. For instance, Vipassana, which involves systematically scanning different body parts, may demand a sustained yet dynamic focus with a temporally stable and regular attentional emphasis. In contrast, Shoonya meditation has been described as involving a non-directed or defocused attentional stance,...
Auditory verbal hallucinations [AVH] are one of the most common psychopathological symptoms in psychosis and schizophrenia [SZ]. While various studies demonstrate the neuronal features of AVH in specific regions and networks including changes in structural and functional connectivity, the relation of their neuronal topography to the organization or structure of the subjects' experience, i.e....
The brain displays intrinsic durations in its own spontaneous activity - Intrinsic Neural Timescales (INTs). INTs are hierarchically organized, with shorter durations within unimodal regions and longer intervals in multimodal domains. Despite significant progress, it's currently not known whether the unimodal-multimodal hierarchical organization undergoes recurrent changes itself - consistent...
What are the exact neuronal mechanisms of pre-post-stimulus interaction and how can that account for the intrinsically subjective nature of the contents of consciousness? This is the key question lurking behind the various excellent and very thoughtful commentaries to our target article which we group along four main topics and questions. (i) What is the role of neural features like alpha...
The psychopathology of schizophrenia is a complex amalgamation of features that span across different dimensions. These dimensions range from the experience of altered time and space through self-disorders to perceptual, positive, and negative symptoms. The relationship between these different psychopathological dimensions remains unclear. Addressing this gap was the aim of our study. We...
Abstract Meditation encompasses diverse practices that train attention inward, in contrast to externally oriented task states. However, the neurodynamic features distinguishing meditative states from non-meditative states across traditions remain unclear. We analyzed high-density EEG data (N=170; 121 advanced meditators, 49 controls) across four traditions: Vipassana, Brahma Kumaris Raja Yoga,...
Neuroscience faces the challenge of connecting brain and mind, with the mind manifesting in first-person experience while the brain's neural activity can only be investigated in third-person perspective. To connect neural and mental states, Neurophenomenology provides a methodological toolkit for systematically linking first-person subjective experience with third-person objective observations...
The default mode network (DMN) exhibits distinct dynamic and topographic features relative to the brain’s other networks, yet their link to consciousness remains unclear. We review both neural (DMN-based topography and dynamics) and mental (experience of time speed, mental time travel, and self-non-self) findings across diverse nonordinary states of consciousness, including reduced (anesthesia,...
Despite major progress in our understanding of the brain, the connection of neural and mental features, that is, brain and mind, remains yet elusive. In our 2020 target paper ("Is temporospatial dynamics the 'common currency' of brain and mind? Spatiotemporal Neuroscience") we proposed the "Common currency hypothesis": temporo-spatial dynamics are shared by neural and mental features, providing...
Introduction Mind-body practices, such as meditation, enhance mental well-being. Research studies consistently demonstrate improved brain function and psychological well-being in meditation practitioners. A substantial body of neuroscientific evidence highlights changes in alpha and theta frequency bands during meditation among practitioners. Neurophysiological effects of meditation are...
While PTSD continues to be researched in great depth, less attention has been given to the continuum of traumatic responses that resides outside this diagnosis. This investigation begins with a literature review examining the spectrum of responses through the lens of the default mode network (DMN). To build upon this literature, a systematic exploratory study was incorporated, examining...
A balanced mind, or equanimity, cultivated through meditation and other spiritual practices, is considered one of the highest mental states. Its core features include deidentification and non-duality. Despite its significance, its neural correlates remain unknown. To address this, we acquired 128-channel EEG data (n = 103) from advanced and novice meditators (from the Isha Yoga tradition) and...
Meditation encompasses a range of practices employing diverse induction techniques, each characterized by a distinct attentional focus. In Mantra meditation, for instance, practitioners direct their attention narrowly to a given sentence that is recursively repeated, while other forms of meditation such as Shoonya meditation are induced by a wider attentional focus. Here we aimed to identify...
The current discussion on the neural correlates of the contents of consciousness (NCCc) focuses mainly on the post-stimulus period of task-related activity. This neglects the substantial impact of the spontaneous or ongoing activity of the brain as manifest in pre-stimulus activity. Does the interaction of pre- and post-stimulus activity shape the contents of consciousness? Addressing this gap...
Consciousness science is marred by disparate constructs and methodologies, making it challenging to systematically compare theories. This foundational crisis casts doubts on the scientific character of the field itself. Addressing it, we propose a framework for systematically comparing consciousness theories by introducing a novel inter-theory classification interface, the Measure Centrality...
Abstract Does artificial intelligence (AI) exhibit consciousness or self? While this question is hotly debated, here we take a slightly different stance by focusing on those features that make possible both, namely a basic or fundamental subjectivity. Learning from humans and their brain, we first ask what we mean by subjectivity. Subjectivity is manifest in the perspectiveness and mineness of...
This scientific commentary refers to ‘Brain dynamics predictive of response to psilocybin for treatment-resistant depression’, by Vohryzek et al. (https://doi.org/10.1093/braincomms/fcae049)
Catatonia is featured by complex symptoms combining motor, affective and behavioral phenomena as well as by its syndrome character with trans-diagnostic occurrence. It paradigmatically shows the limits of current forms of psychopathology like affective and cognitive approaches with respect to both clinical symptoms and brain mechanisms. We therefore suggest Spatiotemporal Psychopathology (STPP)...
Historical authors (e.g., Ludwig Binswanger and Eugène Minkowski) postulated that the experience of patients with schizophrenia is characterized by time fragmentation. From a clinical perspective, patients with schizophrenia also suffer from difficulties in spatial perception (e.g., abnormalities in the experience of interpersonal distance and spatial orientation). Although these changes can...
Time delays are a signature of many physical systems, including the brain, and considerably shape their dynamics; moreover, they play a key role in consciousness, as postulated by the temporo-spatial theory of consciousness (TTC). However, they are often not known a priori and need to be estimated from time series. In this study, we propose the use of permutation entropy (PE) to estimate time...