Biological Psychiatry Global Open Science - The Consciousness Library

Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory

Biological Psychiatry Global Open Science June 4, 2026 Petr Adámek, Veronika Rudolfová, Kristýna Malenínská et al.

Schizophrenia research has traditionally viewed visual processing abnormalities as downstream consequences of cortical dysfunction. However, the epidemiological observation that congenital cortical blindness appears to confer protection against schizophrenia, while peripheral blindness, regardless of its developmental timing, does not, indicates that visual input itself may play a more...

DOI: 10.1016/j.bpsgos.2026.100764 Salience neuroscience Retinal Visual perception Cognitive psychology

Dynamic Repertoire of Brain Networks in Mindfulness-Based Cognitive Therapy During Rumination: A Randomized Controlled Trial

Biological Psychiatry Global Open Science May 14, 2026 Anne Maj van der Velden, Jakub Vohryzek, Paulina Clara Dagnino et al.

BACKGROUND Depression is a prevalent and debilitating affective disorder characterised by the dominance and persistence of depressive rumination. Mindfulness-based cognitive therapy (MBCT) is an effective treatment for recurrent depression developed specifically to target rumination and recurrence risk by training metacognitive awareness and adaptive attention, emotion and self-regulation...

DOI: 10.1016/j.bpsgos.2026.100753 Mindfulness Randomized controlled trial Cognition Repertoire +3

Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis

Biological Psychiatry Global Open Science May 13, 2026 I. Austin-Zimmerman, Qiang Li, E. Johnson et al.

Background Cannabis use is associated with increased risk of psychotic disorders, but the underlying biological mechanisms remain unclear. We used genetic data to investigate the molecular pathways contributing to the association between cannabis use disorder (CUD) and psychosis. Methods We conducted a cross-disorder meta-analysis of genome-wide association studies (GWASs) on schizophrenia and...

DOI: 10.1016/j.bpsgos.2026.100711 Full text

Ketamine Improves Anhedonic Phenotypes Across Species: Translational Evidence From the Probabilistic Reward Task.

Biological Psychiatry Global Open Science May 1, 2026 Mario Bogdanov, Jason N Scott, Shiba M Esfand et al. 1 citation

Ketamine is increasingly used as a therapeutic option for treatment-resistant depression (TRD) due to its rapid antidepressant properties; however, the mechanisms underlying these effects remain elusive. Preclinical evidence suggests ketamine acts on neural pathways implicated in reward processing, but translational efforts have proven challenging due to a lack of paradigms allowing for...

DOI: 10.1016/j.bpsgos.2026.100688 Full text Ketamine Treatment-resistant depression Anhedonia Humans +2

Brain State Dynamics in Ketamine-Induced Dissociation Resemble Those in Posttraumatic Stress Disorder.

Biological Psychiatry Global Open Science March 1, 2026 Noam Goldway, Taly Markovits, Naomi Fine et al. 1 citation

Dissociation, an altered state of consciousness in which individuals feel detached from their body, environment, and sense of self, is a common feature of posttraumatic stress disorder (PTSD). Despite its significance, the neurocognitive processes underlying dissociation remain poorly understood, potentially limiting diagnostic precision and treatment efficacy in PTSD. To address this gap, we...

DOI: 10.1016/j.bpsgos.2025.100655 Full text Ketamine Brain state dynamics Dissociation Network control theory

Cross-Species Evidence for Psilocin-Induced Visual Distortions: Apparent Motion Is Perceived by Both Humans and Rats.

Biological Psychiatry Global Open Science September 1, 2025 Čestmír Vejmola, Klára Šíchová, Kateřina Syrová et al. 4 citations

Psychedelics, particularly psilocin, are increasingly being studied for their mind-altering effects and potential therapeutic applications in psychiatry. Visual hallucinations, especially the illusion of motion in static images, are a hallmark of their action. Despite growing interest, the underlying mechanisms remain poorly understood, as their systematic evaluation in both humans and animals...

DOI: 10.1016/j.bpsgos.2025.100524 Full text Human Psychedelics Rat Visual hallucinations +2

The Induction of Dissociative States: A Meta-Analysis.

Biological Psychiatry Global Open Science July 1, 2025 Benjamin Brake, Lillian Wieder, Natasha Hughes et al. 5 citations

Dissociative states, characterized by discontinuities in awareness and perception, occur in a diverse array of psychiatric disorders and contexts. These states have been experimentally modeled in the laboratory through various induction methods, but relatively little is known about the efficacy and comparability of different experimental methods. In this meta-analysis, we quantified...

DOI: 10.1016/j.bpsgos.2025.100521 Full text Ketamine PTSD Non-ordinary states Mirror gazing +19

Shedding Light on Changes in Subjective Experience During an Intensive Contemplative Retreat: The Lyon Assessment of Meditation Phenomenology Questionnaire.

Biological Psychiatry Global Open Science July 1, 2025 Oussama Abdoun, Arnaud Poublan-Couzardot, Stéphane Offort et al. 5 citations

A significant share of meditation research relies on trait psychometric measures of mindfulness, which neglect the complex and dynamic unfolding of experiential processes entailed by meditation over time. However, there have been a few attempts to capture ongoing changes in experience during meditation. In this study, we integrated and expanded on 3 of these previous approaches to create a...

DOI: 10.1016/j.bpsgos.2025.100474 Full text Mindfulness Phenomenology Experience sampling Pain +2

Transformative Effects of Mindfulness Meditation Training on the Dynamic Reconfiguration of Executive and Default Mode Networks in Internet Gaming Disorder.

Biological Psychiatry Global Open Science July 1, 2025 Shuang Li, Anhang Jiang, Xuefeng Ma et al. 3 citations

Internet gaming disorder (IGD) is a pervasive global mental health issue, and finding effective treatments for the disorder has been challenging. Mindfulness meditation (MM), recognized for its holistic approach that involves integrating mental and physical facets, holds promise for addressing the multifaceted nature of addiction. Nevertheless, the effect of MM on IGD and its associated neural...

DOI: 10.1016/j.bpsgos.2025.100485 Full text Integration Internet gaming disorder Mindfulness meditation Progressive muscle relaxation +1

High Baseline Plasma Anthranilic Acid Predicts Remission Upon Acute-Series Ketamine Infusion for Treatment-Resistant Depression.

Biological Psychiatry Global Open Science July 1, 2025 Stephen A Murata, Zachary B Madaj, Colt D Capan et al. 1 citation

Treatment-resistant depression (TRD) remains a challenge, but intravenous racemic ketamine offers rapid antidepressant effects. Reliable biomarkers are needed. In this study, we examined kynurenine pathway metabolites and inflammatory cytokines as predictors of ketamine response. The Bio-K study was a multicenter, open-label trial of 74 patients with TRD who received 3 ketamine infusions over...

DOI: 10.1016/j.bpsgos.2025.100503 Full text Treatment-resistant depression Biomarkers Anthranilic acid Bio-k +6

Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily Δ9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment.

Biological Psychiatry Global Open Science July 1, 2025 Yalin Sun, Meenalochani Sivasubramanian, Marija Milenkovic et al.

Adolescent-onset cannabis use confers higher risk for neuropsychiatric disorders, implicating amygdala dysfunction. However, the mechanisms that mediate Δ9-tetrahydrocannabinol (THC)-triggered neuroadaptive changes in the maturing amygdala remain unclear. Proteomic analysis of amygdala tissue from male adolescent Saimiri boliviensis nonhuman primates chronically treated with THC provided leads...

DOI: 10.1016/j.bpsgos.2025.100496 Full text Anxiety Adolescent neurodevelopment Amygdala Astrocytes +3

Antidepressant Effects of Nitrous Oxide in Major Depressive Disorder: A Phase 2b Randomized Clinical Trial.

Biological Psychiatry Global Open Science July 1, 2025 Paul S Myles, Jayashri Kulkarni, Jessica Kasza et al.

Nitrous oxide ("laughing gas") is an NMDA receptor antagonist. In the current study, our aim was to investigate the efficacy, safety, and likely optimal dose of nitrous oxide in adults with major depressive disorder (MDD). In this phase 2b randomized, double-blind trial, 81 patients with MDD were allocated on a 1:1 basis to receive nitrous oxide or oxygen/air (control); the nitrous group was...

DOI: 10.1016/j.bpsgos.2025.100504 Full text Treatment-resistant depression Glutamatergic system Major depression Nmda +2

The Hallucinogen Rating Scale: Updated Factor Structure in a Large, Multistudy Sample.

Biological Psychiatry Global Open Science March 1, 2025 Abigail E. Calder, Clifford Qualls, Gregor Hasler et al. 5 citations

The Hallucinogen Rating Scale (HRS) has been widely used to measure the subjective effects of psychedelics and other psychoactive substances. Its advantages include a basis in phenomenological interviews and clinical studies, straightforward items, and broad coverage of psychedelic effects. Previous studies have attempted to resolve its factor structure but were limited by small samples of...

DOI: 10.1016/j.bpsgos.2024.100436 Full text Consciousness studies Psychedelics hallucinogens Entheogens Psychometrics measurement +8

Oscillating Mindfully: Using Machine Learning to Characterize Systems-Level Electrophysiological Activity During Focused Attention Meditation.

Biological Psychiatry Global Open Science March 1, 2025 Noga Aviad, Oz Moskovich, Ophir Orenstein et al.

There has been rapid growth of neuroelectrophysiological studies that aspire to uncover the "black box" of mindfulness and meditation. Reliance on traditional data analysis methods hinders understanding of the complex, nonlinear, multidimensional, and systemic nature of the functional neuroelectrophysiology of meditation states. Thus, to reveal the complex systemic neuroelectrophysiology of...

DOI: 10.1016/j.bpsgos.2024.100423 Full text Meditation Mindfulness Complex systems EEG +1

Serum BDNF Increase After 9-Month Contemplative Mental Training Is Associated With Decreased Cortisol Secretion and Increased Dentate Gyrus Volume: Evidence From a Randomized Clinical Trial.

Biological Psychiatry Global Open Science March 1, 2025 Lara M.c. Puhlmann, Pascal Vrtička, Roman Linz et al.

In this study, we investigated whether mindfulness- and meditation-based mental training that improves stress regulation can upregulate BDNF (brain-derived neurotrophic factor), an important promoter of hippocampal neuroplasticity, and examined cortisol reduction as a mediating pathway. In a randomized clinical trial, 332 healthy adults were randomly assigned to one of the 3 training cohorts or...

DOI: 10.1016/j.bpsgos.2024.100414 Full text Meditation Bdnf Cortisol Hippocampus +2

Effect of an 18-Month Meditation Training on Telomeres in Older Adults: A Secondary Analysis of the Age-Well Randomized Controlled Trial.

Biological Psychiatry Global Open Science 2025 Perla Kaliman, María Jesús Álvarez-López, Asrar Lehodey et al.

Shorter telomeres are associated with increased risk of cognitive decline and age-related diseases. Developing interventions to promote healthy aging by preserving telomere integrity is of paramount importance. Here, we investigated the effect of an 18-month meditation intervention on telomere length (TL) measures in older people without cognitive impairment. A total of 137 adults age ≥65 years...

DOI: 10.1016/j.bpsgos.2024.100398 Full text Meditation Aging Pbmc Personality +3

Modulation of Posterior Default Mode Network Activity During Interoceptive Attention and Relation to Mindfulness.

Biological Psychiatry Global Open Science November 1, 2024 Dhakshin Ramanathan, Jason Nan, Gillian Grennan et al. 10 citations

Interoceptive attention to internal sensory signals, such as the breath, is fundamental to mindfulness. However, interoceptive attention can be difficult to study, with many studies relying on subjective and retrospective measures. Response consistency is an established method for evaluating variability of attention on exteroceptive attention tasks, but it has rarely been applied to...

DOI: 10.1016/j.bpsgos.2024.100384 Full text Default mode network Mindfulness Attention Breathing +2

Dynamic Functional Connectivity Correlates of Trait Mindfulness in Early Adolescence.

Biological Psychiatry Global Open Science November 1, 2024 Isaac N Treves, Hilary A Marusak, Alexandra Decker et al. 7 citations

Trait mindfulness-the tendency to attend to present-moment experiences without judgment-is negatively correlated with adolescent anxiety and depression. Understanding the neural mechanisms that underlie trait mindfulness may inform the neural basis of psychiatric disorders. However, few studies have identified brain connectivity states that are correlated with trait mindfulness in adolescence,...

DOI: 10.1016/j.bpsgos.2024.100367 Full text Adolescents Brain states Dynamics Hyperconnectivity +1

Exploring the Embodied Mind: Functional Connectome Fingerprinting of Meditation Expertise.

Biological Psychiatry Global Open Science November 1, 2024 Sébastien Czajko, Jelle Zorn, Loïc Daumail et al. 5 citations

Short mindfulness-based interventions have gained traction in research due to their positive impact on well-being, cognition, and clinical symptoms across various settings. However, these short-term trainings are viewed as preliminary steps within a more extensive transformative path, presumably leading to long-lasting trait changes. Despite this, little is still known about the brain...

DOI: 10.1016/j.bpsgos.2024.100372 Full text Meditation Mindfulness Cognitive defusion Connectome +2

Decoding Depth of Meditation: Electroencephalography Insights From Expert Vipassana Practitioners

Biological Psychiatry Global Open Science October 17, 2024 Nicco Reggente, Christian Kothe, Tracy Brandmeyer et al. 15 citations

Meditation practices have demonstrated numerous psychological and physiological benefits, but capturing the neural correlates of varying meditative depths remains challenging. In this study, we aimed to decode self-reported time-varying meditative depth in expert practitioners using electroencephalography (EEG). Expert Vipassana meditators ( n = 34) participated in 2 separate sessions....

DOI: 10.1016/j.bpsgos.2024.100402 Meditation Electroencephalography Decoding methods Speech recognition +3

Experiences of Awe Mediate Ketamine's Antidepressant Effects: Findings From a Randomized Controlled Trial in Treatment-Resistant Depression.

Biological Psychiatry Global Open Science July 1, 2024 Julia Aepfelbacher, Benjamin Panny, Rebecca B Price 13 citations

Ketamine, an NMDA receptor antagonist, provides rapid antidepressant effects. Although much research has focused on neural and molecular mechanisms of action, it is critical to also consider psychological mechanisms that may contribute to its therapeutic efficacy. The construct of an awe-inducing experience, which is a well-validated psychological phenomenon tied to emotional well-being, had...

DOI: 10.1016/j.bpsgos.2024.100316 Full text Mediation Mediator Psychological Ketamine therapy +4

The Nonclassic Psychedelic Ibogaine Disrupts Cognitive Maps.

Biological Psychiatry Global Open Science 2024 Victorita E. Ivan, David P Tomàs-Cuesta, Ingrid M. Esteves et al. 7 citations

The ability of psychedelic compounds to profoundly alter mental function has been long known, but the underlying changes in cellular-level information encoding remain poorly understood. We used two-photon microscopy to record from the retrosplenial cortex in head-fixed mice running on a treadmill before and after injection of the nonclassic psychedelic ibogaine (40 mg/kg intraperitoneally). We...

DOI: 10.1016/j.bpsgos.2023.07.008 Full text Ibogaine Neuronal avalanches Path integration Psychedelics +14

Persistent Brain Connectivity Changes in Healthy Volunteers Following Nitrous Oxide Inhalation.

Biological Psychiatry Global Open Science October 1, 2023 Ben Julian A Palanca, Charles R Conway, Thomas Zeffiro et al.

Nitrous oxide holds promise in the treatment of major depressive disorder. Its psychotropic effects and NMDA receptor antagonism have led to comparisons with ketamine. Despite longstanding use, persistent effects of nitrous oxide on the brain have not been characterized. Sixteen healthy volunteers were recruited in a double-blind crossover study. In randomized order, individuals underwent a...

DOI: 10.1016/j.bpsgos.2023.01.006 Full text Depression Ketamine Functional connectivity Nmda receptor +1

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