Although Nicholas of Cusa and Zhuangzi belong, respectively, to the traditions of Christian theology and Chinese Daoist thought, systematic comparisons of their philosophies within a shared framework of human finitude and the pursuit of transcendence remain relatively scarce. Both take reflection on the limits of human cognition and on “ignorance” as the point of departure for their thought,...
PURPOSE Hemophilic arthropathy is a debilitating condition characterized by recurrent hemarthroses, leading to severe joint pain and eventual need for total knee arthroplasty (TKA). Postoperative pain management in this population is highly complex as the result of inherent bleeding risks, intense perioperative anxiety, and a frequently observed "pain-fear-immobility" cycle. The growing need...
Ketamine is increasingly used as a therapeutic option for treatment-resistant depression (TRD) due to its rapid antidepressant properties; however, the mechanisms underlying these effects remain elusive. Preclinical evidence suggests ketamine acts on neural pathways implicated in reward processing, but translational efforts have proven challenging due to a lack of paradigms allowing for...
Treatment-resistant depression (TRD) accounts for approximately 30% of major depressive disorder cases and has been characterized by altered functional connectivity within and between the Default Mode (DMN) and Frontoparietal networks (FPN). Ketamine can be an effective treatment for TRD, and its antidepressant response has been associated with alterations in resting state functional...
Objective: Both intravenous (IV) racemic ketamine and intranasal (IN) esketamine have emerged as rapid-acting antidepressants for treatment-resistant depression (TRD) and are increasingly used in clinical settings. Relatively few studies, however, have compared these interventions in larger, naturalistic cohorts. This study was conducted to assess the comparative efficacy and rapidity of...
Internet gaming disorder (IGD) frequently co-occurs with depression. IGD and depression have overlapping and distinct biological and psychological substrates. Mindfulness meditation (MM) has demonstrated efficacy in treating IGD and depression separately. However, its efficacy in treating concurrent IGD and depression and the possible brain mechanisms remain largely unknown. Seventy individuals...
Internet gaming disorder (IGD) is a pervasive global mental health issue, and finding effective treatments for the disorder has been challenging. Mindfulness meditation (MM), recognized for its holistic approach that involves integrating mental and physical facets, holds promise for addressing the multifaceted nature of addiction. Nevertheless, the effect of MM on IGD and its associated neural...
The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), recently identified internet gaming disorder (IGD) as a condition warranting more research, and few empirically validated treatments exist. Mindfulness meditation (MM) has multiple health benefits; however, its efficacy in treating IGD and potential neural mechanisms underlying MM treatment of...
Mystical experiences have always been studied with a sense of awe and mystery both by the laypersons as well as the scientists.Today due to advancements in Spiritual Psychology, Consciousness studies and Meditation studies, they are being explored from a scientific perspective.As a result several features, identifying criteria, and unique characteristic of these experiences have surfaced in...
Danika Dai, Courtney Miller, Violeta Valdivia et al.
preprint
Abstract BackgroundKetamine has emerged as a rapid-acting antidepressant in treatment-resistant depression (TRD) increasingly used in non-research, clinical settings. Few studies, however, have examined neurocognitive effects of repeated racemic ketamine infusion treatments in patients with TRD. In an effort to identify potential effects after serial infusions, we conducted a retrospective...