Biological Psychiatry Global Open Science
May 1, 2026
Mario Bogdanov, Jason N Scott, Shiba M Esfand et al.
1 citation
Ketamine is increasingly used as a therapeutic option for treatment-resistant depression (TRD) due to its rapid antidepressant properties; however, the mechanisms underlying these effects remain elusive. Preclinical evidence suggests ketamine acts on neural pathways implicated in reward processing, but translational efforts have proven challenging due to a lack of paradigms allowing for...
Translational Psychiatry
March 6, 2026
Ty Lees, Jason N Scott, Brian W. Boyle et al.
Treatment-resistant depression (TRD) accounts for approximately 30% of major depressive disorder cases and has been characterized by altered functional connectivity within and between the Default Mode (DMN) and Frontoparietal networks (FPN). Ketamine can be an effective treatment for TRD, and its antidepressant response has been associated with alterations in resting state functional...
Journal of Clinical Psychiatry
September 22, 2025
Robert C. Meisner, Shuang Li, Brian W. Boyle et al.
5 citations
Objective: Both intravenous (IV) racemic ketamine and intranasal (IN) esketamine have emerged as rapid-acting antidepressants for treatment-resistant depression (TRD) and are increasingly used in clinical settings. Relatively few studies, however, have compared these interventions in larger, naturalistic cohorts. This study was conducted to assess the comparative efficacy and rapidity of...
PNAS Nexus
September 1, 2025
Xin Luo, Huabin Wang, Xuefeng Xu et al.
Internet gaming disorder (IGD) frequently co-occurs with depression. IGD and depression have overlapping and distinct biological and psychological substrates. Mindfulness meditation (MM) has demonstrated efficacy in treating IGD and depression separately. However, its efficacy in treating concurrent IGD and depression and the possible brain mechanisms remain largely unknown. Seventy individuals...
Biological Psychiatry Global Open Science
July 1, 2025
Shuang Li, Anhang Jiang, Xuefeng Ma et al.
3 citations
Internet gaming disorder (IGD) is a pervasive global mental health issue, and finding effective treatments for the disorder has been challenging. Mindfulness meditation (MM), recognized for its holistic approach that involves integrating mental and physical facets, holds promise for addressing the multifaceted nature of addiction. Nevertheless, the effect of MM on IGD and its associated neural...
JAMA Network Open
June 3, 2024
Haosen Ni, Huabin Wang, Xuefeng Ma et al.
The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), recently identified internet gaming disorder (IGD) as a condition warranting more research, and few empirically validated treatments exist. Mindfulness meditation (MM) has multiple health benefits; however, its efficacy in treating IGD and potential neural mechanisms underlying MM treatment of...