Hearing loss affects communication and hinders personal attention and cognitive ability. We hypothesized that noise‐induced hearing loss (NIHL) patients during long‐term noise exposure may result in multimodal plastic changes in the nonauditory central nervous system.
BiologyApril 1, 2025F. R. Azarias, Gustavo Henrique Doná Rodrigues Almeida, Luana Felix de Melo et al.
Simple Summary The Default Mode Network (DMN) is a brain network that becomes active when the brain is at rest. It is crucial for processes like self-reflection, emotional processing, social interaction, and mental exploration. Research has shown that the DMN is not exclusive to humans but is also found in non-human animals, suggesting its evolutionary importance across species. The DMN plays a...
The default mode network (DMN) is intricately linked with processes such as self-referential thinking, episodic memory recall, goal-directed cognition, self-projection, and theory of mind. In recent years, there has been a surge in the number of studies examining its functional connectivity, particularly its relationship with frontoparietal networks involved in top-down attention, executive...
Mindfulness has gained widespread recognition for its benefits for mental health, cognitive performance, and well-being. However, the multifaceted nature of mindfulness, which encompasses elements such as attentional focus, emotional regulation, and present-moment awareness, complicates its definition and measurement. A key component that may underlie its broad benefits is equanimity-the...
Introduction The Attention Training Technique (ATT) is a psychotherapeutic intervention in Metacogntive Therapy (MCT) and aims at reducing maladaptive processes by strengthening attentional flexibility. ATT has demonstrated efficacy in treating depression on a clinical level. Here, we evaluated ATT at the neural level. We examined functional connectivity (FC) of the default mode network (DMN)....
Exercise is an effective non-pharmacological strategy to enhance cognitive function in individuals with mild cognitive impairment (MCI). Our previous studies confirmed that aerobic dance can increase the amplitude of low-frequency fluctuations (LFF) in bilateral fronto-temporal, entorhinal, anterior cingulate, and para-hippocampal cortices. However, its effects on structural connections remain...
Neuroimage: ReportsMarch 1, 2025Nicky Lute, I. Lemmers-Jansen, L. Krabbendam et al.
Resting-state connectivity of the default-mode network (DMN) is aberrant in patients with chronic psychotic disorders as well in individuals with early stage psychosis. Studies of the DMN in healthy volunteers revealed that the DMN comprises several subnetworks. However, it is not yet clear if connectivity between and within these DMN subnetworks is aberrant in patients with early psychotic...
eNeuroMarch 1, 2025Yi-Jia Ma, Joshua A. Brown, Chao-Wen Chen et al.
Alpha (8–12 Hz) oscillations and default mode network (DMN) activity dominate the brain's intrinsic activity in the temporal and spatial domains, respectively. They are thought to play crucial roles in the spatiotemporal organization of the complex brain system. Relatedly, both have been implicated, often concurrently, in diverse neuropsychiatric disorders, with accruing electroencephalogram...
Anhedonia is a core transnosographic symptom in several neuropsychiatric disorders. Recently, the Triple Network (TN) model has been proposed as a useful neurophysiological paradigm for conceptualizing anhedonia, providing new insights to clinicians and researchers. Despite this, the relationship between the functional dynamics of TN and the severity of anhedonia has been relatively...
BACKGROUND: Depression is a prevalent and debilitating affective disorder characterised by the dominance and persistence of depressive rumination. Mindfulness-based cognitive therapy (MBCT) is an effective treatment for recurrent depression developed specifically to target rumination and recurrence risk by training metacognitive awareness and adaptive attention, emotion and self-regulation...
The default mode network (DMN) is implicated in many aspects of complex thought and behavior. Here, we leverage postmortem histology and in vivo neuroimaging to characterize the anatomy of the DMN to better understand its role in information processing and cortical communication. Our results show that the DMN is cytoarchitecturally heterogenous, containing cytoarchitectural types that are...
Lower back pain comprises the majority of the disease burden of patients with ankylosing spondylitis (AS), while the alterations of the large-scale brain networks could be implicated in the neuropathophysiology of pain. The frontoparietal network (FPN) is known as a pain modulation hub, with key nodes dorsolateral prefrontal cortex (dlPFC) and ventrolateral prefrontal cortex (vlPFC)...
Mind wandering (MW) encompasses both a deliberate and a spontaneous disengagement of attention from the immediate external environment to unrelated internal thoughts. Importantly, MW has been suggested to have an inverse relationship with mindfulness, a state of nonjudgmental awareness of present-moment experience. Although they are, respectively, associated with increased and decreased...
Background: Recent clinical trials suggest promising antidepressant effects of psilocybin, despite methodological challenges. While various studies have investigated distinct mechanisms and proposed theoretical opinions, a comprehensive understanding of psilocybin’s neurobiological and psychological antidepressant mechanisms is lacking. Aims: Systematically review potential antidepressant...
Psychedelics, historically celebrated for their cultural and spiritual significance, have emerged as potential breakthrough therapeutic agents due to their profound effects on consciousness, emotional processing, mood, and neural plasticity. This review explores the mechanisms underlying psychedelics’ effects, focusing on their ability to modulate brain connectivity and neural circuit activity,...
What happens in the brain when a person spends three hours viewing a single painting? Geoffrey Schott examines the account of an art history professor who did just that, and considers what their observations reveal about the differences between seeing and looking, and between looking and perceiving.
RATIONALE AND OBJECTIVES Alzheimer's disease (AD) is the most common pathogenesis of dementia, and mild cognitive impairment (MCI) is considered as the intermediate stage from normal elderly to AD. Early detection of MCI is an essential step for the timely intervention of AD to slow the progression of this disease. Different form previous studies in the whole-brain spontaneous activities, this...
Resting‐state functional connectivity analyses have been used to examine synchrony in neural networks in substance use disorders (SUDs), with the default mode network (DMN) one of the most studied. Prior research has generally found less DMN synchrony during use and greater synchrony during cessation, although little research has utilized this method with opioid use. This study examined resting...
Background: The Default Mode Network (DMN) is involved in self-referential and emotional processes, while the insula integrates emotional and interoceptive signals. Functional connectivity between the insula and the DMN is proposed to enhance these processes by linking internal bodily states with self-referential thoughts and emotional regulation. Heart Rate Variability (HRV), a measure of...
The Cingulo-Opercular Network (CON) is a crucial executive control network involved in regulating actions and facilitating higher-order cognitive processes. Resting-state functional connectivity between the CON and the Default Mode Network (DMN) plays a vital role in cognitive regulation, enabling the transition between internally focused and externally directed tasks. This study investigates...