Exploring the Role of Psychedelics in Modulating Ego and Treating Neuropsychiatric Disorders.
ACS Chemical Neuroscience May 7, 2025 DOI: 10.1021/acschemneuro.5c00247 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Viewpoint Peer reviewed |
|---|---|
| Topics | Default mode network LSD Psilocybin |
| Keywords | Ego Neuropsychiatric diseases Psychedelics hallucinogens Entheogens Mental health psychiatry Neuropsychiatry Mental illness Behavioral health |
| Citations | 5 |
| Key points | Psychedelics modulate brain entropy and ego dissolution to disrupt rigid neural patterns, offering therapeutic potential for neuropsychiatric disorders. |
Abstract
This viewpoint explores the therapeutic potential of psychedelics in treating neuropsychiatric disorders, particularly through the modulation of brain entropy and the experience of ego dissolution. Psychedelics disrupt rigid neural patterns, facilitating enhanced connectivity and fostering profound emotional breakthroughs that may alleviate symptoms of disorders like depression, anxiety, PTSD, and addiction. Despite their promising potential, the clinical application of psychedelics presents significant challenges, including the need for careful patient screening, managing adverse experiences, and addressing ethical considerations, all of which are essential for their safe integration into therapy.
Citations in the library
Cited by 5
- Psychedelics and the Gut Microbiome: Unraveling the Interplay and Therapeutic Implications. ACS Chemical Neuroscience July 9, 2025
- Psychedelics and mental health: reimagining care through science, insight, and compassion. Frontiers in Pharmacology September 3, 2025
- Psychedelics and the Extracellular Matrix: Rewiring Neuroplasticity and Metaplasticity for Next-Generation Psychiatric Therapies Biological Psychiatry February 1, 2026
- The Medial Prefrontal Cortex Modulates Psychedelic-like Effects of Psilocin ACS Pharmacology & Translational Science July 8, 2025
- Chemical ecology and convergent evolution of natural hallucinogens: From ecological defense to conserved neural targets Proceedings of the National Academy of Sciences June 24, 2026
Cites 4
- The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs Frontiers in Human Neuroscience 2014
- MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nature Medicine June 1, 2021
- Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects Neuropsychopharmacology February 25, 2022
- Psychedelics as Therapeutics-Potential and Challenges. JAMA Psychiatry July 26, 2023