Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of (14)C-tryptophan into (14)C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of (14)C-tryptophan conversion into (14)C-5-hydroxytryptamine. The...
10 γ/kg i.p. of LSD potentiate the adrenal ascorbic acid depletion caused in rats by 25 γ/kg i.p. of epinephrine, 40 γ/kg i.p. of BOL are ineffective in this respect. 30 γ/kg i.p. of both serotonin and bufotenin potentiate the effects of epinephrine (25 γ/kg i.p.). The threshold doses of bufotenin and serotonin enhancing the epinephrine induced contractions of cat's nictitating membrane were...
SummaryTranquilizing drugs: Frenquel (0.8 mg/1), chlorpromazine (0.1 mg/1) and reserpine (0.4 mg/1), antagonize serotonin-induced uterine contractions, though they do not affect sensitivity of the uterus of the spayed rat either to ACh or oxytocin. The period of antagonism is longer lasting with reserpine than with chlorpromazine and is shortest with Frenquel. Mescaline (0.1 mg/1) causes a...