Medical Toxicology: Diagnosis and Treatment of Human Poisoning.
Annals of Internal Medicine March 1, 1988 957 citations
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Annals of Internal Medicine
ISSN 0003-4819
8 papers in the library · 1,339 citations · publishing 1941-2025
Papers
THE MORPHINE ABSTINENCE SYNDROME, ITS NATURE AND TREATMENT
Annals of Internal Medicine November 1, 1941 C. K. Himmelsbach 147 citations
Drug addiction is a condition where an individual loses self-control over continued drug use, making separation from the drug essential for treatment. Tolerance, habituation, and physical dependence vary among addictions to opiates, marijuana, barbiturates, alcohol, tobacco, caffeine, and other drugs. Tolerance refers to reduced responsiveness to a drug's effects.
Cardiovascular Effects of 3,4-Methylenedioxymethamphetamine: A Double-Blind, Placebo-Controlled Trial
Annals of Internal Medicine December 19, 2000 Steven J. Lester, Matthew J. Baggott, Susette Welm et al. 140 citations
A modest oral dose of MDMA (1.5 mg/kg) increases heart rate by 28 beats per minute, systolic blood pressure by 25 mm Hg, diastolic blood pressure by 7 mm Hg, and cardiac output by 2 L per minute in healthy adults who have used the drug before. These cardiovascular effects are similar to those of the heart stimulant dobutamine at doses of 20 to 40 micrograms per kilogram per minute. Unlike dobutamine, MDMA shows no measurable effect on the heart's pumping strength (inotropism). The findings suggest that even moderate MDMA use raises myocardial oxygen demand without enhancing the heart's contractile force.
The Paradox of Phencyclidine (PCP) Abuse
Annals of Internal Medicine March 1, 1979 R. C. Stillman, Robert C. Petersen 38 citations
Phencyclidine (PCP, known as 'angel dust') is a dangerous drug with acute and chronic risks. High accidental doses can cause severe or fatal medical complications, acute and recurrent psychoses, suicidal depressions, and unpredictable violence. Chronic use leads to aggressiveness, psychological dependence, memory loss, and physiological dependence. Its use is widespread, and among abused drugs it has no current rivals for its disturbing effects.
The Rise of Psilocybin Use in the United States: A Multisource Observational Study
Annals of Internal Medicine April 21, 2025 Karilynn M Rockhill, Joshua C. Black, Michael S. Ladka et al. 29 citations
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LSD-LIKE DELIRIUM FOLLOWING INGESTION OF A SMALL AMOUNT OF ITS BROM ANALOG (BOL-148)
Annals of Internal Medicine May 1, 1958 Nicholas T. Richards, Latasha Chapman, H Goodell et al. 16 citations
Ingestion of a small amount of 2-bromo-d-lysergic acid diethylamide (BOL-148), a bromine analog of LSD, produced a delirium resembling that caused by LSD itself. BOL-148 was previously thought to block the psychological effects of LSD, but the case reported here demonstrates that it can also induce an LSD-like mental disturbance. The compound is known to have an anti-serotonin effect, similar to LSD, which may underlie its psychoactive properties.
High-Concentration Delta-9-Tetrahydrocannabinol Cannabis Products and Mental Health Outcomes : A Systematic Review.
Annals of Internal Medicine October 1, 2025 Thanitsara Rittiphairoj, Louis Leslie, Jean-Pierre Oberste et al. 12 citations
High-concentration THC cannabis products are consistently linked to worse mental health outcomes, especially psychosis or schizophrenia and cannabis use disorder. Among 99 studies (over 221,000 participants), 70% of non-therapeutic studies found unfavorable associations with psychosis or schizophrenia, and 75% found unfavorable associations with cannabis use disorder. For anxiety and depression, about half of non-therapeutic studies reported unfavorable associations, particularly in healthy populations. Some therapeutic studies suggested benefits for anxiety (47%) and depression (48%), but these findings were low-quality and inconsistent. More than 95% of the studies had moderate or high risk of bias.
Low-dose ketamine safely reduces acute pain in the ED with a more rapid and shorter effect than morphine.
Annals of Internal Medicine April 1, 2024 Evan S Schwarz
A meta-analysis of 15 randomized controlled trials compared low-dose ketamine with morphine for acute pain in the emergency department. The analysis suggests that low-dose ketamine provides comparable pain relief to morphine, with a similar onset of action. However, ketamine was associated with a higher incidence of minor, transient side effects such as dizziness, nausea, and psychomimetic effects, while morphine carried a greater risk of respiratory depression and hypotension. The findings indicate that low-dose ketamine is a viable alternative to morphine for managing acute pain in the emergency setting, particularly when avoiding opioid-related adverse effects is a priority.