Lysergic Acid Diethylamide (LSD-25)
A M A Archives of Neurology & Psychiatry September 1, 1958 DOI: 10.1001/archneurpsyc.1958.02340090081013 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Siamese fighting fish |
| Interventions | potassium cyanide sodium azide hydrazine oxygen lack methylene blue Bindschedler's green |
| Topics | LSD |
| Citations | 8 |
| Key findings | Potassium cyanide and sodium azide act on the Siamese fighting fish, similar to the previously observed behavioral effects of LSD-25. |
Abstract
Although it is known that lysergic acid diethylamide (LSD-25) enters the brain, the mechanism by which LSD-25 acts to produce the psychotic patterns in man is unknown. Experiments which are designed to investigate the brain process in the intact animal might lead to a concept that could be developed to study the chemical process originating or connected with clinically occurring schizophrenia. We have recently been studying the effect of potassium cyanide, sodium azide, hydrazine, and oxygen lack, among other respiration inhibitors, on an intact animal, the Siamese fighting fish. In addition, the action of oxidation-reduction indicators, like methylene blue, Bindschedler's green, and other dye systems, has been explored. It has previously been shown that the behavior of the Siamese fighting fish changes markedly in the presence of small doses of LSD-25 in the surrounding water.1-3It may now be reported that KCN and sodium azide act on the Siamese
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 3
- Production of Cross-Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide and Psilocybin The Journal of Psychology 1960
- The intracranial injection of drugs in goldfish. I: Hallucinogens and their antagonism to smooth muscle activity Journal of Asthma Research 1979
- Characterization of behavioral and endocrine effects of LSD on zebrafish. Behavioural Brain Research June 1, 2010