Science
1969
Robert C. Lin, S. H. Ngai, E. Costa
69 citations
Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of (14)C-tryptophan into (14)C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of (14)C-tryptophan conversion into (14)C-5-hydroxytryptamine. The...
Science
September 6, 1968
Luolin S. Browning
29 citations
d-Lysergic acid diethylamide causes a significant increase in recessive lethal mutations in the X chromosome of Drosophila males after intraperitoneal injection of massive doses.
Science
August 16, 1968
George K. Aghajanian, Warren E. Foote, Michael H. Sheard
406 citations
Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased...
Science
June 21, 1968
Robert S. Sparkes, John Melnyk, Louis P. Bozzetti
63 citations
Chromosome studies of persons exposed to lysergic acid diethylamide, either self-administered or received during medical therapy, failed to demonstrate significant chromosomal damage.
Science
June 14, 1968
Niels E. Skakkebæk, J. Philip, Ole J. Rafaelsen
62 citations
Meiotic chromosomes of six mice injected with high doses of lysergic acid diethylamide (LSD-25) and of six controls were studied. Several breaks, gaps, and unidentifiable fragments were found in the treated but, with a few exceptions, not in the control animals. Secondary constrictions were more numerous in the treated than in the untreated mice. Possible consequences are discussed.
Science
March 15, 1968
Philip H. Abelson
15 citations
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Science
February 16, 1968
Josef Warkany, E Takács
55 citations
Lysergic acid diethylamide (LSD) in doses of 1.5 to 300 micrograms was given to 55 pregnant rats during periods of organogenesis and on the 4th or 5th day of pregnancy to 34 rats. Examination of the resultant 887 young for congenital defects showed no greater frequency than in controls. These experiments failed to prove that LSD is teratogenic in rats.
Science
November 3, 1967
Solomon H. Snyder, Louis A. Faillace, Leo E. Hollister
146 citations
We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. In low doses, this compound produces a mild euphoria. Doses greater than 3 milligrams may cause pronounced hallucinogenic effects lasting about 8 hours and similar to those produced by hallucinogenic doses of lysergic...
Science
October 27, 1967
William D. Loughman, Thornton W. Sargent, David M. Israelstam
94 citations
Leukocyte cultures from eight human subjects who had had recent exposure to large doses of lysergic acid diethylamide were examined for chromosome abnormalities. The number of abnormalities was not significantly greater than that in control cultures.
Science
October 13, 1967
William F. Geber
87 citations
Malformations of the brain, spinal cord, liver, and other viscera; body edema; and localized hemorrhages were found in fetal hamsters from mothers injected subcutaneously with a single dose of mescaline, lysergic acid diethylamide, or 2-bromo-D lysergic acid diethylamide on the 8th day of pregnancy. In addition, all three drugs produced an increase in the percentages of small fetuses per...
Science
September 22, 1967
Thomas N. Chase, George R. Breese, Irwin J. Kopin
1 citation
Slices of rat brain which had accumulated tritiated serotonin either in vivo or in vitro were superfused and electrically stimulated. There occurred a marked release of the exogenous amine and, to a lesser extent, its deaminated metabolites, which varied with the region of brain tested and was inhibited by lysergic acid diethylamide.
Science
September 15, 1967
Robert Auerbach, James A. Rugowski
96 citations
Injection of lysergic acid diethylamide tartrate into mice in early pregnancy caused a 57 percent incidence of grossly abnormal embryos.
Science
July 21, 1967
S. T. Irwin, José Egozcue
139 citations
A significant increase of chromosomal abnormalities was found in leukocytes from LSD-25 users (six out of eight) compared to nonuser controls (one out of nine). The two LSD-25 users showing no damage reported the lowest estimated average dose. The subjects whose cells showed damage were tested between 1 day and 6 months after their last LSD-25 dose.
Science
March 17, 1967
Maimon M. Cohen, Michelle J. Marinello, Nathan Back
199 citations
Addition of lysergic acid diethylamide to cultured human leukocytes resulted in a marked increase of chromosomal abnormalities. The distribution of chromosome breaks deviated significantly from random, with an accumulation of aberrations in chromosome No. 1. Cytogenetic investigation of a patient extensively treated with this drug over a 4-year period for paranoid schizophrenia showed a similar...
Science
January 13, 1967
L. P. Gilmour, R. D. O’brien
7 citations
Psilocybin, a hallucinogen, formed a blue color with a subfraction of rat-brain mitochondria believed to contain nerve-ending particles. Color formation increased with p H, did not require oxygen, and involved a component that could not be solubilized. The effect was not shown by chemically related neuroactive compounds, such as bufotenine and serotonin, and was antagonized by only tyramine or...
Science
September 9, 1966
Terry Pivik, David Foulkes
Dream content elicited following the selective deprivation of rapid-eye-movement sleep was intensified compared to that elicited under nondeprivation conditions. This effect was observed both for repressers and for sensitizers, but was significant only for repressers. On nondeprivation nights, the dream periods of sensitizers were shorter and their dreams more intense than those of repressers.
Science
December 3, 1965
Yuji Takeo, Harold E. Himwich
25 citations
Transections of the brain of rabbit reveal that electroencephalographic arousal produced by injections of adrenaline takes place at the midbrain level, while mescaline and 3,4-dimethoxyphenylethylamine induce such arousal lower in the brainstem, at the medullary level.
Science
December 7, 1962
Louis Jolyon West, Chester M. Pierce, Warren D. Thomas
84 citations
A saline pond in a region in Antarctia where other lakes and ponds are frozen remains unfrozen at the prevailing low temperatures. The ecology of the pond is unique. A distinctive aerobic microbial population, though restricted to this natural habitat, adapts to growth in artificial culture. The growth habit of these organisms, as seen in nature and in laboratory culture, indicates a possible...
Science
June 1, 1962
D. W. Woolley, N.k. Campbell
13 citations
These psychotomimetic analogs of serotonin act like this hormone in some tests and against it in others.
Science
August 4, 1961
Julius Axelrod
183 citations
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine, mescaline, and dopamine.
Science
June 26, 1959
W Penfield
The interpretive cortex has in it a mechanism for instant reactivation of the detailed record of the past. It has a mechanism also for the production of interpretive signals. Such signals could only be significant if past records are scanned and relevant experiences are selected for comparison with present experience. This is a subconscious process. But it may well be that this scanning of past...
Science
November 30, 1956
Charles W. Simon, William H. Emmons
Monopolar occipital and vertex EEGs were taken from 21 normal, male, alpha-dominant adults during an 8-hour sleep. Information was presented by means of a tape recorder during this period. Subjects reported if they heard the information during stimulation and were later tested, upon rising, to see if they could recall it. These two variables were correlated with electroencephalographic patterns...
Science
July 20, 1956
E Shaw, D. W. Woolley
88 citations
296MetricsTotal Downloads29Last 6 Months1Last 12 Months6Total Citations6Last 6 Months0Last 12 Months0View all metrics
Science
December 31, 1954
Akira Horita, James M. Dille
44 citations
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