LSD in Mice: Abnormalities in Meiotic Chromosomes
Niels E. Skakkebæk, J. Philip, Ole J. Rafaelsen
Science June 14, 1968 DOI: 10.1126/science.160.3833.1246 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled experiment Peer reviewed |
|---|---|
| Sample size | 12 |
| Population | Mice |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Dose | high doses |
| Topics | LSD |
| Keywords | Meiosis Genetics |
| Citations | 62 |
| Key findings | High doses of LSD-25 induced chromosomal breaks, gaps, and fragments in meiotic chromosomes of treated mice compared to controls. |
Abstract
Meiotic chromosomes of six mice injected with high doses of lysergic acid diethylamide (LSD-25) and of six controls were studied. Several breaks, gaps, and unidentifiable fragments were found in the treated but, with a few exceptions, not in the control animals. Secondary constrictions were more numerous in the treated than in the untreated mice. Possible consequences are discussed.