Psilocybin: Reaction with a Fraction of Rat Brain
L. P. Gilmour, R. D. O’brien
Science January 13, 1967 DOI: 10.1126/science.155.3759.207 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Laboratory experiment Peer reviewed |
|---|---|
| Population | Rat-brain mitochondria subfraction |
| Intervention | Psilocybin |
| Topics | Psilocybin Serotonin |
| Keywords | Hallucinogen Ethylenediaminetetraacetic acid Biophysics Pharmacology |
| Citations | 7 |
| Key findings | Psilocybin produces a blue color with a specific rat-brain mitochondrial subfraction, a reaction not shared by similar compounds and antagonized only by tyramine or EDTA. |
Abstract
Psilocybin, a hallucinogen, formed a blue color with a subfraction of rat-brain mitochondria believed to contain nerve-ending particles. Color formation increased with p H, did not require oxygen, and involved a component that could not be solubilized. The effect was not shown by chemically related neuroactive compounds, such as bufotenine and serotonin, and was antagonized by only tyramine or ethylenediaminetetraacetic acid.
Comparable studies
Other experimental studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers | 1998 | Experimental study | |
| Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin Participants in controlled laboratory experiments receiving a moderate to high oral... | 2015 | Validation study using pooled data from five laboratory experiments | n = 184 |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer Participants with cancer-related psychiatric distress who completed a parent randomized... | 2020 | Long-term within-subjects follow-up analysis | n = 15 |
| Enzymatic Synthesis of Psilocybin | 2017 | Laboratory study |
Citations in the library
Cited by 3
- Occurrence and use of hallucinogenic mushrooms containing psilocybin alkaloids TemaNord May 19, 2009
- The evolution and ecology of psilocybin in nature. Fungal Genetics and Biology June 1, 2023
- Utility of preclinical models in the study of psilocybin – A comprehensive review Neuroscience & Biobehavioral Reviews January 13, 2023