Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster
Science October 13, 1967 DOI: 10.1126/science.158.3798.265 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Fetal hamsters |
| Interventions | mescaline lysergic acid diethylamide 2-bromo-D lysergic acid diethylamide |
| Topics | LSD Mescaline |
| Keywords | Hamster Fetus Pregnancy Teratology Exencephaly Physiology Pharmacology |
| Citations | 87 |
| Key findings | A single dose of mescaline, LSD, or 2-bromo-LSD on the 8th day of pregnancy produced malformations in multiple organs and increased fetal mortality and resorptions in hamsters. |
Abstract
Malformations of the brain, spinal cord, liver, and other viscera; body edema; and localized hemorrhages were found in fetal hamsters from mothers injected subcutaneously with a single dose of mescaline, lysergic acid diethylamide, or 2-bromo-D lysergic acid diethylamide on the 8th day of pregnancy. In addition, all three drugs produced an increase in the percentages of small fetuses per litter, of resorptions, and of fetal mortality.