Chromosomal Damage in Human Leukocytes Induced by Lysergic Acid Diethylamide
Science March 17, 1967 Maimon M. Cohen, Michelle J. Marinello, Nathan Back 199 citations
Addition of lysergic acid diethylamide to cultured human leukocytes resulted in a marked increase of chromosomal abnormalities. The distribution of chromosome breaks deviated significantly from random, with an accumulation of aberrations in chromosome No. 1. Cytogenetic investigation of a patient extensively treated with this drug over a 4-year period for paranoid schizophrenia showed a similar...