Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds
Science August 4, 1961 DOI: 10.1126/science.134.3475.343 (opens in new tab) via OpenAlex
Summary
AI-generated from the abstractAn enzyme that N-methylates serotonin and tryptamine into the psychotomimetic compounds bufotenine and N,N-dimethyltryptamine has been identified. This enzyme is highly concentrated in rabbit lung and also acts on phenylethylamine derivatives including tyramine, phenylethylamine, mescaline, and dopamine.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbit lung |
| Topics | Mescaline Psilocybin Serotonin |
| Keywords | Psychotomimetic Tryptamine Phenethylamine Tyramine |
| Citations | 183 |
| Key finding | An enzyme localized in rabbit lung N-methylates serotonin and tryptamine to produce psychotomimetic metabolites and also acts on several phenylethylamine derivatives. |
Abstract
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine, mescaline, and dopamine.