Serotonin Release from Brain Slices by Electrical Stimulation: Regional Differences and Effect of LSD
Thomas N. Chase, George R. Breese, Irwin J. Kopin
Science September 22, 1967 DOI: 10.1126/science.157.3795.1461 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rat brain slices |
| Interventions | electrical stimulation lysergic acid diethylamide |
| Topics | LSD Serotonin |
| Keywords | Stimulation In vivo In vitro Biogenic amine Amine gas treating Pharmacology Biophysics Endocrinology |
| Citations | 1 |
| Key findings | Electrical stimulation of rat brain slices that had accumulated tritiated serotonin caused release of the amine and its deaminated metabolites, which varied by brain region and was inhibited by lysergic acid diethylamide. |
Abstract
Slices of rat brain which had accumulated tritiated serotonin either in vivo or in vitro were superfused and electrically stimulated. There occurred a marked release of the exogenous amine and, to a lesser extent, its deaminated metabolites, which varied with the region of brain tested and was inhibited by lysergic acid diethylamide.
Comparable studies
Other experimental studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Neural correlates of the LSD experience revealed by multimodal neuroimaging. Human participants | 2016 | Experimental study | |
| Crystal structure of an LSD-bound human serotonin receptor | 2017 | Experimental study with structural biology and molecular dynamics simulations | |
| Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Midbrain neurons containing serotonin | 1968 | Experimental study | |
| Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Human brain | 2017 | Experimental study | |
| LSD-Assisted Psychotherapy in Patients with Terminal Cancer Cancer patients | 1973 | Experimental study | n = 60 |
Citations in the library
Cited by 4
- Antagonism of 5‐hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25 British Journal of Pharmacology October 1, 1970
- A study of the role of noradrenaline in behavioural changes produced in the rat by psychotomimetic drugs British Journal of Pharmacology February 1, 1969
- Effect of N,N-Dimethyltryptamine and D-Lysergic Acid Diethylamide on the Release of 5-Hydroxyindoles in Rat Forebrain Nature April 1, 1971
- Nerve terminal effects of indoleamine psychotomimetics on 5-hydroxytryptamine. Neuroscience & Biobehavioral Reviews 1982