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July 6, 2022
Giovana Gonçalves Gallo, Daniela Fernandez Curado, Mayra Pires Alves Machado et al.
4 citations
Abstract The development of mental health disorders is common in the university population, and mindfulness-based interventions (MBIs) seem to be effective in addressing them in different contexts. Thus, this study investigated the impact of MBIs on different symptoms related to mental health problems. University students (n = 136) were randomized into MBI group or wait-list group. All...
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June 21, 2022
Resting-state EEG functional networks organization and individual differences in the task-unrelated thoughts: Greater Mind-Wanderers exhibit weaker default mode network integration
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May 25, 2022
Effectiveness of Anapana, Body scan and Metta meditation techniques on chronic neck and shoulder region pain and disability in adult patients in Sri Lanka.: study protocol for a cluster clinic-level parallel randomised controlled trial
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April 28, 2022
David Wyndham Lawrence, Robin Carhart-Harris, Roland R. Griffiths et al.
2 citations
Abstract Background: Understanding the phenomenology and content of the inhaled N, N, dimethyltryptamine (N, N-DMT) experience is critical to facilitate and support ongoing research and therapeutic models targeting mental health conditions and central nervous system pathology. Methods: Qualitative analysis of all N, N-DMT experiences posted to the r/DMT Reddit community over a 10-year period...
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April 20, 2022
Aviv Aharon-Almagor, Frederick S. Barrett
Abstract Recent research has demonstrated potential therapeutic effects of hallucinogens, but little is known regarding enduring effects of hallucinogens on human brain structure. Preclinical findings suggest micro-scale structural neuroplastic changes after hallucinogen administration. The current study sought to investigate the association between hallucinogen use, macroscale brain structure,...
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February 25, 2022
Nightmares, Mindfulness And Lucid Dreaming
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January 6, 2022
Hadley Rahrig, David R. Vago, Matthew A. Passarelli et al.
2 citations
Abstract This meta-analysis sought to expand upon neurobiological models of mindfulness through investigation of inherent brain network connectivity outcomes, indexed via resting state functional connectivity (rsFC). We conducted a systematic review and meta-analysis of rsFC as an outcome of mindfulness training (MT) relative to structurally-equivalent programs, with the hypothesis that that MT...
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July 15, 2021
The Logic Fundamentals of Machine Consciousness: Theory of Tri-State
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June 15, 2021
Dennis Parker Kelley, Katy Venable, Gerald Billac et al.
1 citation
Abstract Post-traumatic stress disorder (PTSD) is associated with cognitive deficits, oxidative stress and inflammation. N,N-dimethyltryptamine (DMT) is a known neuroprotective, antioxidant, anti-inflammatory, and psychoplastogen with antidepressant effects. Therefore, we tested the capacity of DMT, the monoamine oxidase inhibitor (MAOI) harmaline, and “pharmahuasca” (DMT + harmaline) to reduce...
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May 20, 2021
Richard E. Daws, Christopher Timmerman, Bruna Giribaldi et al.
11 citations
Abstract Importance Psilocybin therapy shows antidepressant potential; our data link its antidepressant effects to decreased brain network modularity post-treatment. Objective To assess the sub-acute impact of psilocybin on brain activity in patients with depression. Design Pre vs post-treatment resting-state functional MRI (fMRI) was recorded in two trials: 1) Open-label treatment-resistant...
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July 7, 2020
Fear of COVID-19 and Mental Health: The Role of Mindfulness in During Time of Crisis
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Ulrich Gergs, Hannes Jacob, Pauline Braekow et al.
1 citation
Abstract Introduction: Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT4 serotonin receptors and/or H2 histamine receptors. Methods: We studied isolated electrically stimulated left atrial preparations, spontaneously beating right atrial preparations, and spontaneously beating Langendorff-perfused hearts from transgenic mice...
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Majid Eslami, Laleh Khorshidi, Maryam Ghasemi et al.
Abstract 3,4‐methylenedioxymethamphetamine (MDMA) or "Ecstasy", which has been used for recreational purposes, is shown to cause learning and memory impairment. Statins, beyond their efficient cholesterol-lowering action through inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-COA) reductase, possess multiple neuroprotective impacts referred to as pleiotropic effects. In this regard, we aimed...
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Taqwa B. Thanoon, Zeina A. Althanoon
Abstract Maternal depression during pregnancy adversely affects offspring neurodevelopment and behaviour. Typical antidepressants like selective serotonin reuptake inhibitors have limitations due to risks of crossing the placenta. Ketamine has emerged as a promising alternative treatment. This research examined ketamine's effects on offspring of maternally stressed mice. Dams were divided into...
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Alice Le Berre
Abstract Background: Treatment-resistant depression (TRD) involves impaired hippocampal plasticity. Preclinical work showed synaptic potentiation and dendritic spine growth in the dentate gyrus (DG) after esketamine (ESK), but human evidence is lacking. We aimed to detect early DG changes after ESK using advanced diffusion MRI, and to test whether baseline MRI metrics predict clinical response....
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Minna Chang
Abstract Ketamine has been shown to be a novel and exciting antidepressant medication in patients with treatment-resistant depression. A complication commonly seen in frequent and heavy recreational use of ketamine is ulcerative cystitis, which presents with lower urinary tract symptoms (LUTS) and upper renal tract damage, seen in over 25% of regular users (3, 4). Although KIC is a recognised...
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Norihiro Okada, Kenshiro Oshima, Akiko Maruko et al.
Abstract In response to a state of stress, the body attempts to maintain protein homeostasis through intron retention (IR). In other words, by examining which genes undergo IR under stress (i.e., IR genes), it is possible to analyze what type of stress the body is experiencing (Okada et al. 2024 Front.Psychiatry). Using this principle, we re-analyzed the RNA-seq data of non-responders and...
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Sean M. Viña
Abstract Background: Due to increasing cultural and legal acceptance of psychedelics, there is a need to understand their potential influence on formal mental health care. This paper examines the connection between psychedelics, distress, and treatment utilization. Are psychedelic users less likely to use formal mental health care? Methods This study tests the relationship between psychedelics...
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Amit Kumar
Abstract Possession trance involves single or episodic alterations in the state of consciousness, characterized by the exchange of the person’s customary identity with a new identity usually attributed to a spirit, divine power, deity, or another person. In this possessed state, the individual exhibits stereotypical and culturally determined behaviors or experiences being controlled by the...
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Katelyn Halpape, Raelle Pashovitz, Annabelle Wanson et al.
Abstract Background Ketamine is a promising therapy for treatment-resistant depression due to its rapid onset, although benefits are often transitory, with patients needing maintenance therapy to prevent relapse. Most data supporting ketamine for treatment-resistant depression refers to the intravenous route of administration, leaving alternative routes lacking in data, especially as...
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Jack Swain, Davis Carter, Leonardo Vando et al.
Abstract Background Sleep disturbances are a significant public health burden affecting 50 to 70 million adults in the United States and contributing to impaired cognition, accelerated disease progression, and increased mortality risk. 1,2 Available pharmacological treatments carry notable safety and tolerability risks, while access to the leading evidence-based behavioral intervention,...