Research Square
January 12, 2024
Erik Kaadt, Rolf Søkilde, Hanne D. Hansen et al.
Abstract Novel treatment strategies are needed to overcome some of the current challenges related to treatment resistance and treatment latency within the psychiatric field. Recently, psilocybin has shown promise as a novel treatment of major depressive disorder. A single dose of psilocybin is associated with lasting changes in personality and mood. In parallel, various studies have indicated...
Research Square
January 10, 2024
Developing empathy as a process of re-humanization: insights from South American students and their experiences with contemplative practices.
Research Square
December 28, 2023
Margareth Nogueira, Daiane C Ferreira Golbert, Richardson Menezes et al.
2 citations
Abstract Serotonergic psychedelics have potential therapeutic effects in treating anxiety and mood disorders, often after a single dose, and are suggested to have plasticity-inducing action. One lesser studied psychedelic, the 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), is suggested to have anxiolytic effects yet a comprehensive mechanism of action is still lacking. Here, we investigated the...
Research Square
December 28, 2023
Joshua M. Poulin, Gregory E. Bigford, Krista L. Lanctôt et al.
1 citation
Abstract Background: Major Depressive Disorder (MDD) is a leading cause of disability worldwide across domains of health and cognition, affecting overall quality of life. Approximately one third of individuals with depression do not fully respond to treatments (e.g., conventional antidepressants, psychotherapy) and alternative strategies are needed. Recent early phase trials suggest psilocybin...
Research Square
December 13, 2023
David Sjöström, Emma Claesdotter-Knutsson, Petri Kajonius
Abstract Interest in psychedelics is increasing due to potential for improved mental health and quality of life. However, adverse effects on mental health are still a concern. Personality traits have been suggested to both influence the psychedelic experience and mental health, and even be changed by psychedelic use. The present study describes for the first time a national sample of Swedish...
Research Square
November 20, 2023
Ottone Baccaredda Boy, Giuseppe Pierpaolo Merola, Andrea Patti et al.
Abstract the present paper describes the preliminary results of a study centered on the effect of salience alterations and cannabis use on the intensity of psychotic symptoms in adolescent and adult cohorts. The exploratory analysis focused on cross-sectional scores at psychometric questionnaires of 64 participants allocated to 4 different subgroups. A hierarchical pattern in the...
Research Square
October 30, 2023
Consciousness transitions during epilepsy seizures through the lens of Integrated Information Theory
Research Square
October 4, 2023
preprint
Implicitly Activating Mindfulness: Does Trait Self-Control Moderate Its Effect on Aggressive Behaviour?
Research Square
October 3, 2023
Christopher Pittenger, Cheng Jiang, Ralph Dileone et al.
Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear. We used a combination of pharmacological, behavioral, and molecular approaches in rats to test the contribution of the prefrontal endogenous opioid system to the antidepressant-like effects of a single dose of ketamine. Both the behavioral actions...
Research Square
August 16, 2023
Anurag Jayswal, Kabita Devi, Ajanta Deka et al.
Abstract In this study, we are implementing an easy technique of coordination between breathing and thumb movement on finger divisions, which is performed with closed eyes for a short duration of five minutes. This technique has been practiced by a small group of 28 participants in a natural classroom setting and its immediate impact on calming down and inducing sleep was observed distinctly (p...
Research Square
August 8, 2023
Mindflow in crisis: the mediating role of psychological capital and coping competence between mindfulness and flow during COVID-19.
Research Square
July 20, 2023
Orr Shahar, Alexander Botvinnik, Amit Shwartz et al.
3 citations
Abstract Psilocybin, a naturally occurring, tryptamine alkaloid prodrug, is currently being investigated for the treatment of a range of psychiatric disorders. Preclinical reports suggest that the biological effects of psilocybin-containing mushroom extract or “full spectrum” (psychedelic) mushroom extract (PME), may differ from those of chemically synthesized psilocybin (PSIL). We compared the...
Research Square
July 11, 2023
Cultivating well-being, community cohesion and sense of purpose through African contemplative practices
Research Square
June 27, 2023
Louise Hecker, Kosuke Kato, Jennifer Kleinhenz et al.
Abstract Psilocybin is the psychoactive substance contained in the psilocybe(hallucinogenic) mushroom, which has received considerable attention among the scientific community in recent years. Human studies have demonstrated that even a single-dose of psilocybin can improve debilitating physical and psychological symptoms with durable long-term effects. >136 clinical studies with psilocybin...
Research Square
May 5, 2023
Nargess Rahnama, Gholamreza Malek Zadeh, Mohammad Moshtari
From Mindfulness to Flow in the Coronavirus Pandemic: Investigating the mediating role of psychological capital and coping competence. (a cross-sectional study of pre-Hospital Emergency staff)
Research Square
March 20, 2023
Ahmed N. Hassan, Sean Ferkul, Zena Agabani et al.
Abstract Background : There is a need for expanded options for therapeutic interventions for patients with posttraumatic stress disorder (PTSD) and substance use disorder (SUD). The study aimed to examine evidence for the feasibility, safety, and acceptability of a virtual Mantram Repetition Program for adults with PTSD and SUD. Methods : This project utilized mixed-method design (explanatory...
Research Square
March 14, 2023
Robert Palmer, Corey Roos, Nilofar Vafaie et al.
1 citation
Abstract We aimed to elucidate the effects of “dose” of a single-session of mindfulness meditation on state mindfulness and affect as well as moderators of effects. 372 adults recruited remotely via Amazon’s MTurk platform were randomly assigned to either a: 10-minute mindfulness meditation, 20-minute mindfulness meditation, 10-minute control, or 20-minute control. Control conditions were...
Research Square
March 10, 2023
Xue Chen, Jing Li, Lisa Yu et al.
Abstract Psychedelic indolethylamines have emerged as potential medicines to treat several psychiatric pathologies. Natural sources of these compounds include ‘magic mushrooms’, plants used to prepare ahayuasca, and toads. Owing to the occurrence of indolethylamines such as N,N-dimethyltryptamine, toad skin and parotid gland preparations have a history of ceremonial use, yet their biosynthesis...
Research Square
February 14, 2023
Frank Sánchez-Quijano, Diana Ximena Puerta-Cortés, Julio Eduardo Mazorco-Salas
Abstract This pilot study aims to compare the effects of mindfulness and holotropic breathwork treatments on adolescents in the rehabilitation process for psychoactive substance use. Participants comprised 18 female adolescents aged 15–18 admitted to the Fundación Grupo de Apoyo, affiliated with the Colombian Family Welfare Institute. The Fundación is dedicated to rehabilitation from,...
Research Square
November 29, 2022
A Chain Mediation Model Reveals The Association Between Mindfulness and Depression of College students
Research Square
November 15, 2022
Kennedy Robertson, Ian Gold, Samuel P. L. Veissière et al.
Abstract Purpose: Delusional ideation, defined as false beliefs and altered thinking, has long been attributed to anomalous/bizarre perceptual experiences and reasoning deficits. Recent studies, however, have challenged this view, suggesting instead that delusional ideation may have more of a social component to its phenomenology and underlying mechanisms. This study investigated associations...
Research Square
October 26, 2022
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
6 citations
Abstract Psychedelic drugs, including lysergic acid diethylamide (LSD) and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought...
Research Square
September 23, 2022
M. Grifell, Guillem Mir, Roger Estelrich-Azubide et al.
Abstract Background Despite the proliferation of new psychoactive substances (NPS) in recent years, there are many gaps in our understanding of the phenomena. Current methodologies still fail to provide timely and scientifically reliable knowledge between controlled trials and online data reports that lack analytical confirmation of the reported substances. This study tests a new online,...
Research Square
September 20, 2022
Jakub Vohryzek, Joana Cabral, Louis-David Lord et al.
10 citations
Abstract Psilocybin therapy for depression has started to show promise, yet the underlying causal mechanisms are not currently known. Here we leveraged the differential outcome in responders and non-responders to psilocybin (10mg and 25mg, 7 days apart) therapy for depression - to gain new insights into regions and networks implicated in the restoration of healthy brain dynamics. We used...
Research Square
September 8, 2022
Maria Helha Fernandes-Nascimento, André Brooking Negrão, Karine Viana-Ferreira et al.
Abstract Objective To evaluate the publications on ibogaine use for substance-related disorders treatment over the last three decades. Method Bibliometric analysis of publications on ibogaine for the treatment of substance-related disorders from 1991 to 2020 using VOSviewer software. We performed a Scopus database search using the terms: ibogaine, 12-methoxybogamine, endabuse, tabernanthe...