Translational Psychiatry
July 4, 2026
Krisha Shah, Rubén Herzog, Alan C. Swann et al.
Ketamine is a fast-acting intervention for treatment-resistant depression (TRD), yet only a subset of patients show robust clinical response, and the underlying neural mechanisms remain unclear. High-order interactions (HOI) derived from multivariate information theory provide a framework for examining nonlinear dependencies among brain regions beyond pairwise connectivity. One such metric, the...
bioRxiv
June 3, 2026
Camilo Espinosa-Curilem, L. Uhrig, Jordie Tasserie et al.
preprint
Understanding how consciousness depends on large-scale brain interactions is key for both the neuroscience of consciousness and clinical translation. However, it requires moving beyond classical pairwise descriptions of functional connectivity, which cannot capture the collective dependencies emerging across multiple brain regions. Here, we use multivariate information theory measures to...
Cell Reports
April 7, 2026
Nicolas Decat, Arthur Le Coz, Jade Sénéchal et al.
A popular view holds that mental experiences uniquely differ between wakefulness and sleep, yet recent work suggests continuity across these stages. Here, we address this question by examining the wake-sleep transition, a window marked by rapid shifts in wake/sleep stages and mental experiences. We recorded electroencephalography (EEG) activity in 92 participants during two daytime resting...
bioRxiv (Cold Spring Harbor Laboratory)
January 13, 2026
Iván Mindlin, Carlos Coronel-Oliveros, Jacobo Sitt et al.
A main characteristic of biological systems is their capacity to dynamically adapt to environmental changes. In the brain, synaptic plasticity enables the strengthening or weakening of connections between neurons, allowing neural circuits to adapt based on experience, learning, and environmental changes. Yet, it is homeostatically regulated such that it avoids excessive proliferation of...
Nature Communications
August 13, 2025
William Wong, Rubén Herzog, Kátia Cristine Andrade et al.
10 citations
Magneto/electroencephalography (M/EEG) studies of dreaming are an essential paradigm in the investigation of neurocognitive processes of human consciousness during sleep, but they are limited by the number of observations that can be collected per study. Dream research also involves substantial methodological and conceptual variability, which poses problems for the integration of results. To...
Communications Biology
September 19, 2024
Iván Mindlin, Rubén Herzog, Laouen Belloli et al.
18 citations
Disorders of consciousness (DoC) represent a challenging and complex group of neurological conditions characterised by profound disturbances in consciousness. The current range of treatments for DoC is limited. This has sparked growing interest in developing new treatments, including the use of psychedelic drugs. Nevertheless, clinical investigations and the mechanisms behind them are...
Translational Psychiatry
July 27, 2024
Rubén Herzog, Florentine Marie Barbey, Md Nurul Islam et al.
13 citations
Ketamine is a dissociative anesthetic that induces a shift in global consciousness states and related brain dynamics. Portable low-density EEG systems could be used to monitor these effects. However, previous evidence is almost null and lacks adequate methods to address global dynamics with a small number of electrodes. This study delves into brain high-order interactions (HOI) to explore the...
Research Square
March 21, 2024
Agustin Ibanez, Rubén Herzog, Florentine Barbey et al.
1 citation
In a double-blinded cross-over design, 30 adults (mean age = 25.57, SD = 3.74; all male) were administered racemic ketamine and compared against saline infusion as a control. Both task-driven (auditory oddball paradigm) and resting-state EEG were recorded. HOI were computed using advanced multivariate information theory tools, allowing us to quantify nonlinear statistical dependencies between...
bioRxiv Preprint Server
December 29, 2023
Iván Mindlin, Rubén Herzog, Laouen Belloli et al.
7 citations
preprint
Disorders of consciousness (DoC) are a challenging and complex group of neurological conditions characterised by absent or impaired awareness. The current range of therapeutic options for DoC patients is limited, offering few non-invasive pharmacological alternatives. This situation has sprung a growing interest in the development of novel treatments, such as the proposal to study the efficacy...
May 16, 2023
William Wong, Kátia C. Andrade, Thomas Andrillon et al.
21 citations
preprint
Magneto/electroencephalography (M/EEG) studies of dreaming are an essential paradigm in the investigation of neurocognitive processes of human consciousness during sleep, but they are limited by the number of observations that can be collected per study. Dream research also involves substantial methodological and conceptual variability, which poses problems for the integration of results. To...
Scientific Reports
April 17, 2023
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
51 citations
Psychedelic drugs, including lysergic acid diethylamide (LSD) and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of...
Research Square
October 26, 2022
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
6 citations
Abstract Psychedelic drugs, including lysergic acid diethylamide (LSD) and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought...
Sci Rep
September 15, 2022
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
3 citations
s attention that there was a typo in the script used to calculate the differential entropy. Therefore, the reported entropy estimations are invalid and do not produce the expected increase in entropy when using
Scientific Reports
October 20, 2020
Rubén Herzog, Pedro A. M. Mediano, Fernando E. Rosas et al.
60 citations
Retracted
Abstract Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be...
arXiv (Cornell University)
August 6, 2020
Rodrigo Cofré, Rubén Herzog, Pedro A. M. Mediano et al.
The scope of human consciousness includes states departing from what most of\nus experience as ordinary wakefulness. These altered states of consciousness\nconstitute a prime opportunity to study how global changes in brain activity\nrelate to different varieties of subjective experience. We consider the problem\nof explaining how global signatures of altered consciousness arise from...
arXiv Preprint Archive
August 6, 2020
Rodrigo Cofré, Rubén Herzog, Pedro A. M. Mediano et al.
The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain activity relate to different varieties of subjective experience. We consider the problem of explaining how global signatures of altered consciousness arise from the interplay...