The study aims to explore the relationship among mindfulness, depression, meaning in life (MIL) and psychological resilience (PR), and verify whether MIL and PR have a chain mediating effect between mindfulness and depression .1034 college students in a province were investigated by using Adolescent Mindfulness Scale, Depression Scale, Meaning in Life Scale and Psychological Resilience Scale....
Research SquareNovember 22, 2022Haifei Shen, Ri Zhang, Xiujie Zhang et al.
preprint
Abstract Purpose: To explore the moderation of mindfulness on the relationship between anxiety and somatization symptoms in middle-aged and elderly female patients with hypertension, and provide foundation for the development of more effective mindfulness intervention strategies. Methods: A total of 109 middle-aged and elderly female patients with hypertension were participated in this...
Abstract Purpose: Delusional ideation, defined as false beliefs and altered thinking, has long been attributed to anomalous/bizarre perceptual experiences and reasoning deficits. Recent studies, however, have challenged this view, suggesting instead that delusional ideation may have more of a social component to its phenomenology and underlying mechanisms. This study investigated associations...
Research SquareNovember 1, 2022Hoda Taghilou, Mazaher Rezaei, Mohammad Ali Nazari et al.
preprint
Abstract Background Most electrophysiological studies in hypnosis have divided individuals into two groups with high and low hypnotizability. However, this classification has been subjected to considerable criticism. The most important of these criticisms is that highly hypnotizable individuals can be divided into different groups due to their heterogeneity. Methods We selected 20 people with a...
Abstract Psychedelic drugs, including lysergic acid diethylamide (LSD) and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought...
Abstract Background Despite the proliferation of new psychoactive substances (NPS) in recent years, there are many gaps in our understanding of the phenomena. Current methodologies still fail to provide timely and scientifically reliable knowledge between controlled trials and online data reports that lack analytical confirmation of the reported substances. This study tests a new online,...
Abstract Psilocybin therapy for depression has started to show promise, yet the underlying causal mechanisms are not currently known. Here we leveraged the differential outcome in responders and non-responders to psilocybin (10mg and 25mg, 7 days apart) therapy for depression - to gain new insights into regions and networks implicated in the restoration of healthy brain dynamics. We used...
Research SquareSeptember 19, 2022Cloé Brami, Franck Zenasni, Liza Hettal et al.
preprint
Background: Improving student wellness through curricular activities is a topic of interest in medical school. Both distress and well-being are related to medical student empathy. Numerous data suggest that learning mindfulness skills help to reduce anxiety, stress and overall psychological distress. Moreover, there are still poor data on the impact of MBSR on medical students' empathy and...
Abstract Objective To evaluate the publications on ibogaine use for substance-related disorders treatment over the last three decades. Method Bibliometric analysis of publications on ibogaine for the treatment of substance-related disorders from 1991 to 2020 using VOSviewer software. We performed a Scopus database search using the terms: ibogaine, 12-methoxybogamine, endabuse, tabernanthe...
Abstract With novel hallucinogens poised to enter psychiatry, we lack a unified framework for quantifying which changes in consciousness are optimal for treatment. Using transformers (i.e. BERT) and 11,816 publicly-available drug testimonials, we first predicted 28-dimensions of sentiment across each narrative, validated with psychiatrist annotations. Secondly, BERT was trained to predict...
Research SquareAugust 3, 2022Lin Ban, Xiaohong Lv, Dawei Cai et al.
preprint
Abstract Death represents the termination of all biological functions that sustain an organism and is inevitable in the ordinary life of people. Throughout history, death has been a topic of discussion. The emotion of fear of death has existed since the birth of human beings and has become even more so after civilization. To alleviate the fear of death, the unknown thing, primitive people began...
Abstract The development of mental health disorders is common in the university population, and mindfulness-based interventions (MBIs) seem to be effective in addressing them in different contexts. Thus, this study investigated the impact of MBIs on different symptoms related to mental health problems. University students (n = 136) were randomized into MBI group or wait-list group. All...
Research SquareJune 21, 2022Paweł Krukow, Kamil Jonak
preprint
When performing cognitively demanding tasks, we all sometimes experience a momentary distractions or our stream of consciousness is intercepted by personal associations. This phenomenon is called Mind Wandering (MW) and it became a subject of neuroscientific investigations. Off-task thoughts can be analyzed during task performance, but currently MW is also understood as a dimension of...
Abstract: BackgroundChronic neck and shoulder region pain affects many people in the world. This study aims to compare the effectiveness of an eight-week training programme on pain and disability in a patient population affected with chronic neck and shoulder region pain, using Anapana, Body Scan and Metta meditation techniques, with a usual care control group and with each other.MethodsThis...
Research SquareMay 5, 2022N.O. Outschoorn, E.a.s.k. Somarathne, H.m.n.n. Dasanayaka et al.
preprint
Background: Buddhist-derived meditation is a well-known phenomenological practice that enhances overall well-being of individuals. However, broad and less-rigorous criteria in recruiting suitable meditation practitioners affect the reliability of results obtained through meditation research. Therefore, we aimed at developing an instrument to identify and recruit skilled meditators to be used in...
Abstract Background: Understanding the phenomenology and content of the inhaled N, N, dimethyltryptamine (N, N-DMT) experience is critical to facilitate and support ongoing research and therapeutic models targeting mental health conditions and central nervous system pathology. Methods: Qualitative analysis of all N, N-DMT experiences posted to the r/DMT Reddit community over a 10-year period...
Abstract Recent research has demonstrated potential therapeutic effects of hallucinogens, but little is known regarding enduring effects of hallucinogens on human brain structure. Preclinical findings suggest micro-scale structural neuroplastic changes after hallucinogen administration. The current study sought to investigate the association between hallucinogen use, macroscale brain structure,...
Abstract Background Mindfulness-based cognitive therapy (MBCT) may have positive physiological and psychological benefits for patients with breast cancer, in addition to enhancing their quality of life. However, few studies have involved synthesis of the relevant literature to confirm these effects. This meta-analysis examined the associations between MBCT and various symptoms after Western...
Abstract Background. Alongside a recent revival in the use of psychedelics in clinical settings, there have been increases in the prevalence of recreational use, with many using psychedelics to deal with difficult emotions or to improve wellbeing. While clinical research is conducted in carefully controlled settings, this is not necessarily the case for recreational use. In this mixed-methods...
Research SquareMarch 8, 2022Gabriella Smedfors, Elliot J. Glotfelty, Negar Kalani et al.8 citations
preprint
Abstract Psilocybin is a psychedelic substance approaching clinical use. The drug has long-lasting effects after single or multiple administrations and enhances structural plasticity in the brain. Little is known if the plasticity inducing effects of psilocybin could be timed to other treatments and promote a larger effect. We investigated the effect of psilocybin on cultured mouse hippocampal...
A theoretical and empirical association between lucid dreaming and mindfulness, as well as lucid dreaming and nightmares has previously been observed; however, the relationship between nightmares and mindfulness has received surprisingly little attention. Here, we present the findings of two studies exploring the relation of nightmare frequency and distress with two components of mindfulness,...
Abstract Background Ketamine has emerged as a promising pharmacotherapy for depression and other mental illnesses, and the intramuscular (IM) administration of ketamine is now offered at many North American outpatient psychiatric clinics. However, a characterization of the outpatient population receiving IM ketamine treatment, and an evaluation of the real-world efficacy and safety of long-term...
Abstract Background Currently, personal or familial histories of psychotic symptoms are exclusionary criteria for most psychedelic clinical trials, studies, and treatment programs. This study sought to determine why such an exclusion exists, what the implications of the exclusion criteria are, and if there was agreement in expert opinion. Methods In-depth interviews with 12 experts in the...
Abstract This meta-analysis sought to expand upon neurobiological models of mindfulness through investigation of inherent brain network connectivity outcomes, indexed via resting state functional connectivity (rsFC). We conducted a systematic review and meta-analysis of rsFC as an outcome of mindfulness training (MT) relative to structurally-equivalent programs, with the hypothesis that that MT...
Background: Preliminary evidence suggests that Mindfulness-Based Cognitive Therapy (MBCT) is a promising treatment for bipolar disorder (BD). One of the proposed working mechanisms of MBCT in attenuating depressive symptoms is through the reduction of depressive rumination. In BD the effect of MBCT on rumination is less well studied. The primary aim of this study was to investigate the effect...