Psychoneuroendocrinology
June 1, 2011
Tonya L Jacobs, Elissa S Epel, Jue Lin et al.
435 citations
After a 3-month meditation retreat with about 6 hours of daily practice, retreat participants showed greater telomerase activity—an indicator of cellular longevity—compared to a matched wait-list control group. Retreat participants also reported increased Perceived Control, Mindfulness, and Purpose in Life, and decreased Neuroticism. Statistical mediation analyses suggested that the retreat's effect on telomerase activity was explained by increases in Perceived Control and decreases in Neuroticism. These changes in perceived control and neuroticism were themselves partially explained by increased Mindfulness and Purpose in Life. Purpose in Life also directly mediated the group difference in telomerase activity, whereas Mindfulness did not. The findings suggest that meditation may influence cellular health through psychological changes.
Annals of the New York Academy of Sciences
August 1, 2009
Elissa S Epel, Jennifer Daubenmier, Judith T. Moskowitz et al.
324 citations
Telomere length, a marker of cellular aging, is linked to chronic stress and depression. Psychological stress cognitions, such as threat appraisals and rumination, can prolong stress reactivity and may shorten telomeres. In contrast, mindfulness meditation shifts appraisals from threat to challenge, reduces rumination and stress arousal, and may increase positive arousal states. A review of data connects telomere length to cognitive stress and arousal, and new data links cognitive appraisal to telomere length. The authors propose that mindfulness meditation may benefit telomere maintenance by reducing cognitive stress and arousal and enhancing positive states, with ongoing trials testing this model.
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
October 1, 2013
Tonya L Jacobs, Phillip R Shaver, Elissa S Epel et al.
62 citations
Cognitive perseverations such as worry and rumination may prolong cortisol release, potentially contributing to disease pathways. Meditation training can increase self-reported mindfulness, which is linked to reductions in such perseverations, but no prior work directly linked mindfulness to resting cortisol output. In an observational study of 57 adults on a 3-month meditation retreat, mindfulness increased from pre- to post-retreat, while cortisol did not significantly change overall. However, mindfulness was inversely related to evening cortisol at both time points, and larger increases in mindfulness were associated with decreases in cortisol, whereas smaller increases or slight decreases in mindfulness were linked to increases in cortisol. These findings suggest a relationship between self-reported mindfulness and resting output of the hypothalamic-pituitary-adrenal system.
JAMA Network Open
January 2, 2025
Rachel M Radin, Julie Vacarro, Elena Fromer et al.
11 citations
A brief digital mindfulness meditation program, compared to a waiting list, reduced perceived stress and job strain among employees of a large academic medical center. In a randomized clinical trial with 1458 adults (mostly female, average age 35.5 years), those assigned to 10 minutes of daily meditation for 8 weeks showed moderate to large improvements in stress and secondary outcomes like burnout and work engagement at 8 weeks, and these benefits persisted at 4 months. Greater daily use of the app (5 to 9.9 minutes versus less than 5 minutes) was linked to larger stress reductions. The findings suggest that a scalable digital meditation program can effectively lower stress in the workplace.
Frontiers in Endocrinology
January 1, 2024
Quinn A Conklin, Anthony P Zanesco, Brandon G King et al.
A month-long silent meditation retreat reduced circulating levels of oxytocin in 28 retreat participants compared to 34 control participants, who showed no change. Higher openness to experience at the start predicted greater oxytocin decreases, and lower oxytocin at the end was linked to stronger feelings of personal connection with fellow meditators. Oxytocin changes were unrelated to attachment style or anxiety. Vasopressin decreased similarly in both groups, indicating no specific retreat effect. The authors interpret these preliminary findings cautiously, noting measurement limitations and suggesting future research to differentiate effects of meditation practices and contexts on oxytocin signaling.
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
January 4, 2025
Elissa S Epel, Brian P Don, Stefanie E Mayer et al.
All four stress-reduction interventions—mindfulness meditation, slow breathing with warm showers, fast-paced breathing with cold showers (the Wim Hof Method), and high-intensity interval training—reduced depressive symptoms by about 16% and perceived stress by about 10% after three weeks in women with high stress. No group outperformed the others immediately after the intervention. However, a post hoc analysis of participants who adhered to their assigned program suggested that the Wim Hof Method group maintained lower depression scores and greater daily positive affect three months later, a finding that requires replication with larger, more diverse samples.
Comprehensive psychoneuroendocrinology
November 1, 2024
Robin Blades, Wendy Berry Mendes, Brian P Don et al.
A three-week intervention comparing the Wim Hof Method (breathing technique inducing intermittent hypoxia plus cold showers) with slow-paced breathing and warm showers in 84 midlife women with high stress and depressive symptoms produced equivalent mental health improvements. Both groups showed a 24% reduction in depressive symptoms, a 27% reduction in anxiety symptoms, and a 20% reduction in perceived stress immediately after the intervention, with gains maintained at three months, when 46% reported mild or no depressive symptoms. Both conditions also reduced daily negative affect and peak cortisol reactivity to a laboratory stressor. However, the Wim Hof Method led to greater reductions in rumination after daily stressful events, a finding needing replication.
Brain, behavior, and immunity
May 1, 2018
Quinn A Conklin, Brandon G King, Anthony P Zanesco et al.
Intensive meditation during a one-month residential Insight retreat was associated with an apparent increase in telomere length compared to a control group of experienced meditators not on retreat. Personality traits moderated this effect: retreat participants highest in neuroticism and lowest in agreeableness showed the greatest telomere length increases. Changes in telomere-related gene expression suggested improved telomere maintenance, including increases in Gar1 and HnRNPA1. No group-level changes in telomerase activity were observed, but retreat participants' telomerase activity at post-assessment was inversely related to retreat engagement and prior meditation experience. Neuroticism also predicted variation in telomerase activity across the retreat.