Research Square
January 12, 2024
Erik Kaadt, Rolf Søkilde, Hanne D. Hansen et al.
preprint
Abstract Novel treatment strategies are needed to overcome some of the current challenges related to treatment resistance and treatment latency within the psychiatric field. Recently, psilocybin has shown promise as a novel treatment of major depressive disorder. A single dose of psilocybin is associated with lasting changes in personality and mood. In parallel, various studies have indicated...
Research Square
January 10, 2024
Gaston Bacquet Quiroga
preprint
Abstract Violence in any of its manifestations is the practice of dehumanizing another. By perpetrating violent acts on another, we diminish their value and take away their dignity. The underlying philosophy of nonviolence, on the other hand, informed as it is by traditions that have historically influenced each other from Hinduism to Western secular movements, is fueled by this understanding...
Research Square
January 4, 2024
Laetitia Vanderijst, Felix Hever, Anne Buot et al.
preprint
Abstract Background: A significant number of individuals with alcohol use disorder remain unresponsive to currently available treatments, which calls for the development of new alternatives. In parallel, psilocybin-assisted therapy for alcohol use disorder has recently yielded promising preliminary results. Building on extant findings, the proposed study is set to evaluate the feasibility and...
Research Square
December 28, 2023
Margareth Nogueira, Daiane C Ferreira Golbert, Richardson Menezes et al.
2 citations
preprint
Abstract Serotonergic psychedelics have potential therapeutic effects in treating anxiety and mood disorders, often after a single dose, and are suggested to have plasticity-inducing action. One lesser studied psychedelic, the 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), is suggested to have anxiolytic effects yet a comprehensive mechanism of action is still lacking. Here, we investigated the...
Research Square
December 28, 2023
Joshua M. Poulin, Gregory E. Bigford, Krista L. Lanctôt et al.
1 citation
preprint
Abstract Background: Major Depressive Disorder (MDD) is a leading cause of disability worldwide across domains of health and cognition, affecting overall quality of life. Approximately one third of individuals with depression do not fully respond to treatments (e.g., conventional antidepressants, psychotherapy) and alternative strategies are needed. Recent early phase trials suggest psilocybin...
Research Square
December 13, 2023
David Sjöström, Emma Claesdotter-Knutsson, Petri Kajonius
preprint
Abstract Interest in psychedelics is increasing due to potential for improved mental health and quality of life. However, adverse effects on mental health are still a concern. Personality traits have been suggested to both influence the psychedelic experience and mental health, and even be changed by psychedelic use. The present study describes for the first time a national sample of Swedish...
Research Square
November 20, 2023
Ottone Baccaredda Boy, Giuseppe Pierpaolo Merola, Andrea Patti et al.
preprint
Abstract the present paper describes the preliminary results of a study centered on the effect of salience alterations and cannabis use on the intensity of psychotic symptoms in adolescent and adult cohorts. The exploratory analysis focused on cross-sectional scores at psychometric questionnaires of 64 participants allocated to 4 different subgroups. A hierarchical pattern in the...
Research Square
November 14, 2023
Félix Schoeller, Abhinandan Jain, Vladimir Adrien et al.
2 citations
preprint
Abstract Background Depression is a major global health challenge, affecting over 300 million people worldwide. Current pharmacological and psychotherapeutic interventions have limited efficacy, underscoring the need for novel approaches. Emerging evidence suggests that peak emotional experiences characterized by awe, transcendence, and meaning hold promise for rapidly shifting maladaptive...
Research Square
October 30, 2023
Fabricio Baglivo, Nuria Campora, Camilo Mininni et al.
preprint
Consciousness is one of the most complex aspects of human experience. Studying the mechanisms involved in transitions and in different levels of consciousness is one of the greatest challenges of neuroscience. In this study we use a measure based on computing the integrated information using an autoregressive system (Φ AR ) to evaluate dynamic changes during consciousness transitions. This...
Research Square
October 19, 2023
H. Charles Li, Thomas T. Hills
preprint
Abstract Mind wandering and daydreaming reflect non-deliberate and deliberate forms of mental exploration. However, it is not yet known to what extent the kinds of things that come to mind during these exploratory events are similar or different. The current research addresses this question by having participants engage in either a mindfulness task or a daydreaming task, with instructions to...
Research Square
October 17, 2023
Fataneh Mahmoodi, Maryam Zarnaghash, Nadereh Sohrabi Shegefti et al.
preprint
Abstract Objective Low level of psychological well-being is one of the most common problems of female heads of households, and various educational programs have been conducted to improve the psychological well-being of this group, the present study was conducted to develop the effect of educational intervention according to Mindfulness on the psychological well-being of female heads of...
Research Square
October 13, 2023
Mirela Simona Calinici, Tudor Calinici, Horatiu Traian Crisan
preprint
Abstract Background The present paper investigates the impact of a mindfulness-based intervention, focused on psychological flexibility and emotional intelligence, in a sample of medical students. Methods The assessed variables were psychological flexibility, emotional intelligence, dysregulation, and distress (depression, anxiety and stress symptoms). The applied intervention was Mindfulness...
Research Square
October 10, 2023
Leanne Harper, Andrew Jones, Laura Goodwin et al.
preprint
Abstract Purpose This study tested whether stressful life events and stressful combat experiences are associated with post-traumatic stress symptomology (PTS-S), via facets of mindfulness, in UK military personnel.Methods A sample of 435 UK veterans were recruited to a cross-sectional, online study. Participants completed self-report measures of stressful life and combat experiences,...
Research Square
October 4, 2023
Rémi Thériault, Stéphane Dandeneau
preprint
Abstract Objectives. Previous research shows that a novel experimental paradigm consisting of implicitly activating (“priming”) concepts associated with mindfulness through a scrambled sentence task yields positive social effects on cognition and affect. Yet, its effects on social behaviour warrant further investigation. As several studies link mindfulness to lower aggression, the latter...
Research Square
October 3, 2023
Christopher Pittenger, Cheng Jiang, Ralph Dileone et al.
preprint
Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear. We used a combination of pharmacological, behavioral, and molecular approaches in rats to test the contribution of the prefrontal endogenous opioid system to the antidepressant-like effects of a single dose of ketamine. Both the behavioral actions...
Research Square
September 18, 2023
Niloufar Ansari, Shabnam Omidvar, Alireza Azizi et al.
preprint
Abstract Background Stress and anxiety are difficult concepts in the preoperative care of pregnant women with a history of cesarean section and are associated with maternal complications. Objectives This study aimed to determine the impact of mindfulness-based counseling on the stress and anxiety of women with a history of cesarean section. Methods Using convenience sampling, the present study...
Research Square
September 6, 2023
Junior Justin, Maryanna Klatt, Catherine Quatman-Yates et al.
preprint
Abstract The purpose was to evaluate the effects of Mindfulness in Motion (MIM), a Mindfulness Based Intervention, on respiration rate, heart rate, and heart rate variability (HRV). Healthcare providers wore chest strap electrocardiography-based (ECG) devices during MIM sessions (n = 84). Data were collected during the following mindfulness-based segments: 5-minute quiet sitting to reflect on...
Research Square
September 1, 2023
José Ferrer Costa, Nuria Moran, Carlos Garcia Marti et al.
2 citations
preprint
Abstract Objective The main objective was to evaluate the impact of an 8-week virtual reality (VR) based educational program teaching mindfulness and emotional management techniques to healthcare professionals. Methods Eighty-six healthcare professionals from two primary care centers and a palliative care team engaged in weekly 10-15 minute VR educational sessions. The sessions focused on...
Research Square
September 1, 2023
Finja Hondrich, Maria von Salisch, Katharina Voltmer
preprint
Abstract Mindfulness-based interventions (MBIs) have been shown to improve children’s academic achievements. Because MBIs include different exercises (with different effects), the teacher-led Breathing Break Intervention (BBI) with daily breath-based mindfulness practices was developed and evaluated in terms of its effects on children’s performance in mathematics. In a randomized controlled...
Research Square
August 28, 2023
preprint
Abstract: After resolution of primary infection, patients are susceptible to more severe secondary infection with unclear underlying mechanisms.To investigate whether esketamine treatment immediately after primary LPS exposure could alleviate second-infection-induced cognitive impairment. In this study, mice were injected intraperitoneally (i.p.) with lipopolysaccharides (LPS; 5 mg/kg) 10 days...
Research Square
August 23, 2023
Lucas Villar Magalhães da Cruz, Bheatrix Bienemann Favero, Fernanda Palhano-Fontes et al.
preprint
Abstract Ayahuasca is a brew with psychoactive properties that has been used as an entheogen for centuries, with more recent studies suggesting it is a promising treatment for some clinical disorders. Although there is an emerging scientific literature on its effects, to the best of our knowledge no study has explored the self-reported experiences of first-time ayahuasca users with quantitative...
Research Square
August 21, 2023
Rebecca Y. M. Cheung, Lemuela Djekou
preprint
Abstract Previous research suggests that mindfulness and mind wandering are opposing constructs. However, little is known about why and how they are negatively related. Through a process-oriented approach, this study tested self-compassion and grit as mediators for the relation between mindfulness and mind wandering. A total of 487 meditators were recruited from the UK (241 female, 49.49%)....
Research Square
August 17, 2023
Nadia Chakroun-Baggioni, Rebecca Shankland, Estelle Fall
preprint
Abstract Although the literature has shown that attachment and mindfulness are related to relationship quality, their cumulative effect remains unclear. This study aims to understand the impact of mindfulness on the relationship between parental and adult attachment styles and the quality of relationships with parents and romantic partners in young adults. Data were collected on 195 first-year...
Research Square
August 16, 2023
Anurag Jayswal, Kabita Devi, Ajanta Deka et al.
preprint
Abstract In this study, we are implementing an easy technique of coordination between breathing and thumb movement on finger divisions, which is performed with closed eyes for a short duration of five minutes. This technique has been practiced by a small group of 28 participants in a natural classroom setting and its immediate impact on calming down and inducing sleep was observed distinctly (p...
Research Square
August 9, 2023
Ophélie Courbet, Quent Daviot, Victoire Kalamarides et al.
preprint
Abstract Mental health issues in children and young people are frequent and can have enduring negative consequences. Preventive early interventions delivered at school may foster psychological well-being, and preliminary evidence suggests that mindfulness-based social and emotional study was to evaluate a mindfulness-based SEL curriculum including a French adaptation of the Kindness Curriculum...